Heritability and other determinants of left ventricular diastolic function in the family-based population study

Malgorzata Kloch-Badelek, Judita Knez, Valerie Tikhonoff, Lutgarde Thijs, Wojciech Sakiewicz, Andrew Ryabikov, Katarzyna Stolarz-Skrzypek, Yu Jin, Sofia Malyutina, Edoardo Casiglia, Krzysztof Narkiewicz, Danuta Czarnecka, Kalina Kawecka-Jaszcz, Jan A. Staessen, Tatiana Kuznetsova*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Web of Science)

Abstract

Understanding to what extent genetic factors influence diastolic Doppler indexes is an important issue in view of the relation of left ventricular diastolic dysfunction with outcome. We, therefore, investigated the heritability of left ventricular diastolic traits and the composite diastolic score in nuclear families recruited from the general population.In a random sample of 316 nuclear families (452 parents and 600 offspring, mean age, 58.5 and 33.3 years), we measured transmitral early and late diastolic velocities (E and A) by pulsed wave Doppler, and mitral annular velocities (e' and a') by tissue Doppler. Using principal component analysis, we summarized seven Doppler indexes - namely, E, A, e' and a' velocities, and their ratios - into a single diastolic score. To calculate the heritability of diastolic indexes, we used variance decomposition in nuclear families and offspring as implemented in SOLAR and SAS, and the regression slope of offspring on mid-parent residual values.In variance decomposition analyses in nuclear families, the abovementioned traits with adjustment for covariables had moderate heritability ranging from 0.27 to 0.43 (P?
Original languageEnglish
Pages (from-to)1854-1861
JournalJournal of Hypertension
Volume32
Issue number9
DOIs
Publication statusPublished - Sep 2014

Keywords

  • diastole
  • echocardiography
  • heritability
  • tissue Doppler imaging

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