Hepatic sinusoidal cells: endothelial cells, Kupffer cells, fat-storing cells and liver-associated lymphocytes

R.C. McCuskey, E. Eddie Wisse

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Abstract

Chapter 9.03 provides an overview of the microscopic structure and functions of the hepatic sinusoid and its component sinusoidal lining cells - fenestrated endothelial cells, which have a high capacity for transvascular exchange and endocytosis; phagocytic Kupffer cells, which are involved in proinflammatory and host defense mechanisms; stellate cells, which store vitamin A and upon activation are involved in fibrosis; and liver-associated lymphocytes, which are involved in immunity. The involvement of these cells in liver injury is also summarized.

Original languageEnglish
Title of host publicationComprehensive Toxicology
EditorsI.G. Sipes, C.A. McQueen, A.J. Gandolfi
Place of PublicationTuscon
PublisherCenter for Toxicology, University of Arizona
Pages31-42
ISBN (Print)0-444-50868-6
DOIs
Publication statusPublished - 1 Jan 2010

Publication series

SeriesCellular and Molecular Toxicology

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