Hemodynamics-driven mathematical model of first and second heart sound generation

Mehrdad Shahmohammadi*, Hongxing Luo, Philip Westphal, Richard N Cornelussen, Frits W Prinzen, Tammo Delhaas

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


NEW & NOTEWORTHY: To the best of our knowledge, this is the first hemodynamic-based heart sound generation model embedded in a complete real-time computational model of the cardiovascular system. Simulated heart sounds are similar to experimental and clinical measurements, both quantitatively and qualitatively. Our model can be used to investigate the relationships between heart sound acoustic features and hemodynamic factors/anatomical parameters.

Original languageEnglish
Article numbere1009361
JournalPLoS Computational Biology
Issue number9
Publication statusPublished - Sept 2021


  • Animals
  • Atrioventricular Block/physiopathology
  • Biomechanical Phenomena
  • Computational Biology
  • Computer Simulation
  • Computer Systems
  • Disease Models, Animal
  • Exercise/physiology
  • Heart Failure/physiopathology
  • Heart Sounds/physiology
  • Heart Valves/physiopathology
  • Hemodynamics/physiology
  • Humans
  • Mathematical Concepts
  • Models, Cardiovascular
  • Phonocardiography/statistics & numerical data
  • Swine

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