Hemodynamics-driven mathematical model of first and second heart sound generation

Mehrdad Shahmohammadi; Hongxing Luo; Philip Westphal; Richard N Cornelussen; Frits W Prinzen; Tammo Delhaas

doi:10.1371/journal.pcbi.1009361

Hemodynamics-driven mathematical model of first and second heart sound generation

Mehrdad Shahmohammadi^*, Hongxing Luo, Philip Westphal, Richard N Cornelussen, Frits W Prinzen, Tammo Delhaas

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

NEW & NOTEWORTHY: To the best of our knowledge, this is the first hemodynamic-based heart sound generation model embedded in a complete real-time computational model of the cardiovascular system. Simulated heart sounds are similar to experimental and clinical measurements, both quantitatively and qualitatively. Our model can be used to investigate the relationships between heart sound acoustic features and hemodynamic factors/anatomical parameters.

Original language	English
Article number	e1009361
Journal	PLoS Computational Biology
Volume	17
Issue number	9
DOIs	https://doi.org/10.1371/journal.pcbi.1009361
Publication status	Published - Sept 2021

Keywords

Animals
Atrioventricular Block/physiopathology
Biomechanical Phenomena
Computational Biology
Computer Simulation
Computer Systems
Disease Models, Animal
Exercise/physiology
Heart Failure/physiopathology
Heart Sounds/physiology
Heart Valves/physiopathology
Hemodynamics/physiology
Humans
Mathematical Concepts
Models, Cardiovascular
Phonocardiography/statistics & numerical data
Swine

Access to Document

10.1371/journal.pcbi.1009361Licence: CC BY

Cite this

@article{6d56c292be274de0bc44f1059d1c41a0,

title = "Hemodynamics-driven mathematical model of first and second heart sound generation",

abstract = "NEW & NOTEWORTHY: To the best of our knowledge, this is the first hemodynamic-based heart sound generation model embedded in a complete real-time computational model of the cardiovascular system. Simulated heart sounds are similar to experimental and clinical measurements, both quantitatively and qualitatively. Our model can be used to investigate the relationships between heart sound acoustic features and hemodynamic factors/anatomical parameters.",

keywords = "Animals, Atrioventricular Block/physiopathology, Biomechanical Phenomena, Computational Biology, Computer Simulation, Computer Systems, Disease Models, Animal, Exercise/physiology, Heart Failure/physiopathology, Heart Sounds/physiology, Heart Valves/physiopathology, Hemodynamics/physiology, Humans, Mathematical Concepts, Models, Cardiovascular, Phonocardiography/statistics & numerical data, Swine",

author = "Mehrdad Shahmohammadi and Hongxing Luo and Philip Westphal and Cornelussen, {Richard N} and Prinzen, {Frits W} and Tammo Delhaas",

note = "Publisher Copyright: {\textcopyright} 2021 Shahmohammadi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

year = "2021",

month = sep,

doi = "10.1371/journal.pcbi.1009361",

language = "English",

volume = "17",

journal = "PLoS Computational Biology",

issn = "1553-7358",

publisher = "Public Library of Science",

number = "9",

}

TY - JOUR

T1 - Hemodynamics-driven mathematical model of first and second heart sound generation

AU - Shahmohammadi, Mehrdad

AU - Luo, Hongxing

AU - Westphal, Philip

AU - Cornelussen, Richard N

AU - Prinzen, Frits W

AU - Delhaas, Tammo

N1 - Publisher Copyright: © 2021 Shahmohammadi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2021/9

Y1 - 2021/9

N2 - NEW & NOTEWORTHY: To the best of our knowledge, this is the first hemodynamic-based heart sound generation model embedded in a complete real-time computational model of the cardiovascular system. Simulated heart sounds are similar to experimental and clinical measurements, both quantitatively and qualitatively. Our model can be used to investigate the relationships between heart sound acoustic features and hemodynamic factors/anatomical parameters.

AB - NEW & NOTEWORTHY: To the best of our knowledge, this is the first hemodynamic-based heart sound generation model embedded in a complete real-time computational model of the cardiovascular system. Simulated heart sounds are similar to experimental and clinical measurements, both quantitatively and qualitatively. Our model can be used to investigate the relationships between heart sound acoustic features and hemodynamic factors/anatomical parameters.

KW - Animals

KW - Atrioventricular Block/physiopathology

KW - Biomechanical Phenomena

KW - Computational Biology

KW - Computer Simulation

KW - Computer Systems

KW - Disease Models, Animal

KW - Exercise/physiology

KW - Heart Failure/physiopathology

KW - Heart Sounds/physiology

KW - Heart Valves/physiopathology

KW - Hemodynamics/physiology

KW - Humans

KW - Mathematical Concepts

KW - Models, Cardiovascular

KW - Phonocardiography/statistics & numerical data

KW - Swine

U2 - 10.1371/journal.pcbi.1009361

DO - 10.1371/journal.pcbi.1009361

M3 - Article

C2 - 34550969

SN - 1553-7358

VL - 17

JO - PLoS Computational Biology

JF - PLoS Computational Biology

IS - 9

M1 - e1009361

ER -

Hemodynamics-driven mathematical model of first and second heart sound generation

Abstract

Keywords

Access to Document

Fingerprint

Cite this