Hemodilution Combined With Hypercapnia Impairs Cerebral Autoregulation During Normothermic Cardiopulmonary Bypass

Ervin E. Severdija, Nousjka P. A. Vranken*, Antoine P. Simons, Erik D. Gommer, John H. Heijmans, Jos G. Maessen, Patrick W. Weerwind

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Objective: To investigate the influence of hemodilution and arterial pCO(2) on cerebral autoregulation and cerebral vascular CO2 reactivity. Design: Prospective interventional study. Setting: University hospital-based single-center study. Participants: Forty adult patients undergoing elective cardiac surgery using normothermic cardiopulmonary bypass. Interventions: Blood pressure variations induced by 6/minute metronome-triggered breathing (baseline) and cyclic 6/min changes of indexed pump flow at 3 levels of arterial pCO(2). Measurements and Main Results: Based on median hematocrit on bypass, patients were assigned to either a group of a hematocrit >= 28% or = 28% and
Original languageEnglish
Pages (from-to)1194-1199
JournalJournal of Cardiothoracic and Vascular Anesthesia
Issue number5
Publication statusPublished - Oct 2015


  • cardiopulmonary bypass
  • cerebral autoregulation
  • cerebral carbon dioxide reactivity
  • hemodilution

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