Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study

Frank Qian; Shengfeng Wang; Jonathan Mitchell; Lesley McGuffog; Daniel Barrowdale; Goska Leslie; Jan C. Oosterwijk; Wendy K. Chung; D. Gareth Evans; Christoph Engel; Karin Kast; Cora M. Aalfs; Muriel A. Adank; Julian Adlard; Bjarni A. Agnarsson; Kristiina Aittomaki; Elisa Alducci; Irene L. Andrulis; Banu K. Arun; Margreet G. E. M. Ausems; Jacopo Azzollini; Emmanuelle Barouk-Simonet; Julian Barwell; Muriel Belotti; Javier Benitez; Andreas Berger; Ake Borg; Angela R. Bradbury; Joan Brunet; Saundra S. Buys; Trinidad Caldes; Maria A. Caligo; Ian Campbell; Sandrine M. Caputo; Jocelyne Chiquette; Kathleen B. M. Claes; J. Margriet Collee; Fergus J. Couch; Isabelle Coupier; Mary B. Daly; Rosemarie Davidson; Orland Diez; Susan M. Domchek; Alan Donaldson; Cecilia M. Dorfling; Ros Eeles; Lidia Feliubadalo; Lenka Foretova; Jeffrey Fowler; Encarna B. Gomez Garcia; GEMO Study Collaborators; HEBON; EMBRACE; Dezheng Huo

doi:10.1093/jnci/djy132

Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study

Frank Qian, Shengfeng Wang, Jonathan Mitchell, Lesley McGuffog, Daniel Barrowdale, Goska Leslie, Jan C. Oosterwijk, Wendy K. Chung, D. Gareth Evans, Christoph Engel, Karin Kast, Cora M. Aalfs, Muriel A. Adank, Julian Adlard, Bjarni A. Agnarsson, Kristiina Aittomaki, Elisa Alducci, Irene L. Andrulis, Banu K. Arun, Margreet G. E. M. AusemsJacopo Azzollini, Emmanuelle Barouk-Simonet, Julian Barwell, Muriel Belotti, Javier Benitez, Andreas Berger, Ake Borg, Angela R. Bradbury, Joan Brunet, Saundra S. Buys, Trinidad Caldes, Maria A. Caligo, Ian Campbell, Sandrine M. Caputo, Jocelyne Chiquette, Kathleen B. M. Claes, J. Margriet Collee, Fergus J. Couch, Isabelle Coupier, Mary B. Daly, Rosemarie Davidson, Orland Diez, Susan M. Domchek, Alan Donaldson, Cecilia M. Dorfling, Ros Eeles, Lidia Feliubadalo, Lenka Foretova, Jeffrey Fowler, Encarna B. Gomez Garcia, GEMO Study Collaborators, HEBON, EMBRACE, Dezheng Huo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Article number	132
Pages (from-to)	350-364
Number of pages	15
Journal	Journal of the National Cancer Institute
Volume	111
Issue number	4
DOIs	https://doi.org/10.1093/jnci/djy132
Publication status	Published - Apr 2019

Keywords

BIOLOGICAL PATHWAYS
GENETIC-VARIANTS
DISEASE
LOCI
IDENTIFICATION
EPIDEMIOLOGY
INSULIN
OBESITY
WEIGHT
FAMILY

Access to Document

10.1093/jnci/djy132

Cite this

Qian, F., Wang, S., Mitchell, J., McGuffog, L., Barrowdale, D., Leslie, G., Oosterwijk, J. C., Chung, W. K., Evans, D. G., Engel, C., Kast, K., Aalfs, C. M., Adank, M. A., Adlard, J., Agnarsson, B. A., Aittomaki, K., Alducci, E., Andrulis, I. L., Arun, B. K., ... Huo, D. (2019). Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study. Journal of the National Cancer Institute, 111(4), 350-364. [132]. https://doi.org/10.1093/jnci/djy132

Qian, Frank ; Wang, Shengfeng ; Mitchell, Jonathan ; McGuffog, Lesley ; Barrowdale, Daniel ; Leslie, Goska ; Oosterwijk, Jan C. ; Chung, Wendy K. ; Evans, D. Gareth ; Engel, Christoph ; Kast, Karin ; Aalfs, Cora M. ; Adank, Muriel A. ; Adlard, Julian ; Agnarsson, Bjarni A. ; Aittomaki, Kristiina ; Alducci, Elisa ; Andrulis, Irene L. ; Arun, Banu K. ; Ausems, Margreet G. E. M. ; Azzollini, Jacopo ; Barouk-Simonet, Emmanuelle ; Barwell, Julian ; Belotti, Muriel ; Benitez, Javier ; Berger, Andreas ; Borg, Ake ; Bradbury, Angela R. ; Brunet, Joan ; Buys, Saundra S. ; Caldes, Trinidad ; Caligo, Maria A. ; Campbell, Ian ; Caputo, Sandrine M. ; Chiquette, Jocelyne ; Claes, Kathleen B. M. ; Collee, J. Margriet ; Couch, Fergus J. ; Coupier, Isabelle ; Daly, Mary B. ; Davidson, Rosemarie ; Diez, Orland ; Domchek, Susan M. ; Donaldson, Alan ; Dorfling, Cecilia M. ; Eeles, Ros ; Feliubadalo, Lidia ; Foretova, Lenka ; Fowler, Jeffrey ; Gomez Garcia, Encarna B. ; GEMO Study Collaborators ; HEBON ; EMBRACE ; Huo, Dezheng. / Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers : A Mendelian Randomization Study. In: Journal of the National Cancer Institute. 2019 ; Vol. 111, No. 4. pp. 350-364.

@article{e652a17756514167bb1f54a660c0ca8a,

title = "Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study",

keywords = "BIOLOGICAL PATHWAYS, GENETIC-VARIANTS, DISEASE, LOCI, IDENTIFICATION, EPIDEMIOLOGY, INSULIN, OBESITY, WEIGHT, FAMILY",

author = "Frank Qian and Shengfeng Wang and Jonathan Mitchell and Lesley McGuffog and Daniel Barrowdale and Goska Leslie and Oosterwijk, {Jan C.} and Chung, {Wendy K.} and Evans, {D. Gareth} and Christoph Engel and Karin Kast and Aalfs, {Cora M.} and Adank, {Muriel A.} and Julian Adlard and Agnarsson, {Bjarni A.} and Kristiina Aittomaki and Elisa Alducci and Andrulis, {Irene L.} and Arun, {Banu K.} and Ausems, {Margreet G. E. M.} and Jacopo Azzollini and Emmanuelle Barouk-Simonet and Julian Barwell and Muriel Belotti and Javier Benitez and Andreas Berger and Ake Borg and Bradbury, {Angela R.} and Joan Brunet and Buys, {Saundra S.} and Trinidad Caldes and Caligo, {Maria A.} and Ian Campbell and Caputo, {Sandrine M.} and Jocelyne Chiquette and Claes, {Kathleen B. M.} and Collee, {J. Margriet} and Couch, {Fergus J.} and Isabelle Coupier and Daly, {Mary B.} and Rosemarie Davidson and Orland Diez and Domchek, {Susan M.} and Alan Donaldson and Dorfling, {Cecilia M.} and Ros Eeles and Lidia Feliubadalo and Lenka Foretova and Jeffrey Fowler and {Gomez Garcia}, {Encarna B.} and {GEMO Study Collaborators} and HEBON and EMBRACE and Dezheng Huo",

year = "2019",

month = apr,

doi = "10.1093/jnci/djy132",

language = "English",

volume = "111",

pages = "350--364",

journal = "Journal of the National Cancer Institute",

issn = "0027-8874",

publisher = "Oxford University Press",

number = "4",

}

Qian, F, Wang, S, Mitchell, J, McGuffog, L, Barrowdale, D, Leslie, G, Oosterwijk, JC, Chung, WK, Evans, DG, Engel, C, Kast, K, Aalfs, CM, Adank, MA, Adlard, J, Agnarsson, BA, Aittomaki, K, Alducci, E, Andrulis, IL, Arun, BK, Ausems, MGEM, Azzollini, J, Barouk-Simonet, E, Barwell, J, Belotti, M, Benitez, J, Berger, A, Borg, A, Bradbury, AR, Brunet, J, Buys, SS, Caldes, T, Caligo, MA, Campbell, I, Caputo, SM, Chiquette, J, Claes, KBM, Collee, JM, Couch, FJ, Coupier, I, Daly, MB, Davidson, R, Diez, O, Domchek, SM, Donaldson, A, Dorfling, CM, Eeles, R, Feliubadalo, L, Foretova, L, Fowler, J, Gomez Garcia, EB, GEMO Study Collaborators, HEBON, EMBRACE & Huo, D 2019, 'Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study', Journal of the National Cancer Institute, vol. 111, no. 4, 132, pp. 350-364. https://doi.org/10.1093/jnci/djy132

Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers : A Mendelian Randomization Study. / Qian, Frank; Wang, Shengfeng; Mitchell, Jonathan; McGuffog, Lesley; Barrowdale, Daniel; Leslie, Goska; Oosterwijk, Jan C.; Chung, Wendy K.; Evans, D. Gareth; Engel, Christoph; Kast, Karin; Aalfs, Cora M.; Adank, Muriel A.; Adlard, Julian; Agnarsson, Bjarni A.; Aittomaki, Kristiina; Alducci, Elisa; Andrulis, Irene L.; Arun, Banu K.; Ausems, Margreet G. E. M.; Azzollini, Jacopo; Barouk-Simonet, Emmanuelle; Barwell, Julian; Belotti, Muriel; Benitez, Javier; Berger, Andreas; Borg, Ake; Bradbury, Angela R.; Brunet, Joan; Buys, Saundra S.; Caldes, Trinidad; Caligo, Maria A.; Campbell, Ian; Caputo, Sandrine M.; Chiquette, Jocelyne; Claes, Kathleen B. M.; Collee, J. Margriet; Couch, Fergus J.; Coupier, Isabelle; Daly, Mary B.; Davidson, Rosemarie; Diez, Orland; Domchek, Susan M.; Donaldson, Alan; Dorfling, Cecilia M.; Eeles, Ros; Feliubadalo, Lidia; Foretova, Lenka; Fowler, Jeffrey; Gomez Garcia, Encarna B.; GEMO Study Collaborators; HEBON; EMBRACE; Huo, Dezheng.

In: Journal of the National Cancer Institute, Vol. 111, No. 4, 132, 04.2019, p. 350-364.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers

T2 - A Mendelian Randomization Study

AU - Qian, Frank

AU - Wang, Shengfeng

AU - Mitchell, Jonathan

AU - McGuffog, Lesley

AU - Barrowdale, Daniel

AU - Leslie, Goska

AU - Oosterwijk, Jan C.

AU - Chung, Wendy K.

AU - Evans, D. Gareth

AU - Engel, Christoph

AU - Kast, Karin

AU - Aalfs, Cora M.

AU - Adank, Muriel A.

AU - Adlard, Julian

AU - Agnarsson, Bjarni A.

AU - Aittomaki, Kristiina

AU - Alducci, Elisa

AU - Andrulis, Irene L.

AU - Arun, Banu K.

AU - Ausems, Margreet G. E. M.

AU - Azzollini, Jacopo

AU - Barouk-Simonet, Emmanuelle

AU - Barwell, Julian

AU - Belotti, Muriel

AU - Benitez, Javier

AU - Berger, Andreas

AU - Borg, Ake

AU - Bradbury, Angela R.

AU - Brunet, Joan

AU - Buys, Saundra S.

AU - Caldes, Trinidad

AU - Caligo, Maria A.

AU - Campbell, Ian

AU - Caputo, Sandrine M.

AU - Chiquette, Jocelyne

AU - Claes, Kathleen B. M.

AU - Collee, J. Margriet

AU - Couch, Fergus J.

AU - Coupier, Isabelle

AU - Daly, Mary B.

AU - Davidson, Rosemarie

AU - Diez, Orland

AU - Domchek, Susan M.

AU - Donaldson, Alan

AU - Dorfling, Cecilia M.

AU - Eeles, Ros

AU - Feliubadalo, Lidia

AU - Foretova, Lenka

AU - Fowler, Jeffrey

AU - Gomez Garcia, Encarna B.

AU - GEMO Study Collaborators

AU - HEBON

AU - EMBRACE

AU - Huo, Dezheng

PY - 2019/4

Y1 - 2019/4

KW - BIOLOGICAL PATHWAYS

KW - GENETIC-VARIANTS

KW - DISEASE

KW - LOCI

KW - IDENTIFICATION

KW - EPIDEMIOLOGY

KW - INSULIN

KW - OBESITY

KW - WEIGHT

KW - FAMILY

U2 - 10.1093/jnci/djy132

DO - 10.1093/jnci/djy132

M3 - Article

C2 - 30312457

VL - 111

SP - 350

EP - 364

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

SN - 0027-8874

IS - 4

M1 - 132

ER -