Heart Rate Dependency of Large Artery Stiffness

Isabella Tan, Bart Spronck, Hosen Kiat, Edward Barin, Koen D. Reesink, Tammo Delhaas, Alberto P. Avolio*, Mark Butlin

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Carotid-femoral pulse wave velocity (cfPWV) quantifies large artery stiffness, it is used in hemodynamic research and is considered a useful cardiovascular clinical marker. cfPWV is blood pressure (BP) dependent. Intrinsic heart rate (HR) dependency of cfPWV is unknown because increasing HR is commonly accompanied by increasing BP. This study aims to quantify cfPWV dependency on acute, sympathovagal-independent changes in HR, independent of BP. Individuals (n=52, age 40-93 years, 11 female) with in situ cardiac pacemakers or cardioverter defibrillators were paced at 60, 70, 80, 90, and 100 bpm. BP and cfPWV were measured at each HR. Both cfPWV (mean [95% CI], 0.31 [0.26-0.37] m/s per 10 bpm; P
Original languageEnglish
Pages (from-to)236-242
Issue number1
Publication statusPublished - Jul 2016


  • blood pressure
  • heart rate
  • pulse wave velocity
  • pulse wave analysis

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