Health-Related Quality of Life in Patients With Atrial Fibrillation Treated With Rhythm Control Versus Rate Control Insights From a Prospective International Registry (Registry on Cardiac Rhythm Disorders Assessing the Control of Atrial Fibrillation: RECORD-AF)

Andrew C. T. Ha*, Guenter Breithardt, A. John Camm, Harry J. Crijns, Garrett M. Fitzmaurice, Peter R. Kowey, Jean-Yves Le Heuzey, Lisa Naditch-Brule, Eric N. Prystowsky, Peter J. Schwartz, Christian Torp-Pedersen, William S. Weintraub, Paul Dorian

*Corresponding author for this work

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Background-Improving health-related quality of life (HRQoL) is an important treatment goal in the management of patients with atrial fibrillation (AF). Uncertainty exists as to whether patients' HRQoL differ when treated with medical rhythm control or rate control. We compared HRQoL between patients treated with rhythm control or rate control in a large observational registry of patients with recent-onset AF. Methods and Results-In the Registry on Cardiac Rhythm Disorders Assessing the Control of Atrial Fibrillation (RECORD-AF), 2439 patients with recent onset (= 3 points. The primary analysis was based on a propensity score-adjusted longitudinal regression analysis which compared the change in AF symptom severity scores between the 2 groups. Over an average follow-up of 1 year, the AF symptom severity scores improved in both groups (rhythm control: -2.82 point [95% confidence interval, -3.22 to -2.41]; rate control: -2.11 point [95% confidence interval, -2.54 to -1.67]; P
Original languageEnglish
Pages (from-to)896-904
JournalCirculation : Cardiovascular Quality and Outcomes
Issue number6
Publication statusPublished - Nov 2014


  • atrial fibrillation
  • quality of life

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