Health-Related Quality of Life in Adrenocortical Carcinoma

Rebecca Steenaard*, Laura A. Michon, Harm R. Haak

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

9 Citations (Web of Science)

Abstract

Insight into the health-related quality of life (HRQoL) impact of adrenocortical carcinoma (ACC) is important. The disease and its treatment options potentially have an impact on HRQoL. For patients with limited survival, HRQoL research is of utmost importance. We will therefore provide an overview of HRQoL studies in patients with ACC. We found six studies that measured HRQoL in 323 patients with ACC (3 cross-sectional, 1 cohort, 2 trials), all indicating a reduced HRQoL compared to the general population. The FIRMACT trial found that HRQoL of patients with ACC was reduced compared to the general population, and that chemotherapy-mitotane further reduced HRQoL even though survival improved. Clinical aspects of the disease, including cortisol and aldosterone production and adrenal insufficiency have shown great impact on HRQoL in benign disease, even after the recovery of hormonal status. However, the impact of malignant adrenal disease and treatment options on HRQoL including adrenalectomy, radiotherapy, mitotane therapy, and chemotherapy have not been sufficiently studied in patients with ACC. Although the number of HRQoL studies in patients with ACC is limited, the existing literature does indicate that ACC has a large impact on patients' HRQoL, with disease specific aspects. Further HRQoL research in patients with ACC is essential to improve patient-centered care, preferably by using an ACC-specific HRQoL questionnaire.

Original languageEnglish
Article number1500
Number of pages13
JournalCancers
Volume11
Issue number10
DOIs
Publication statusPublished - Oct 2019

Keywords

  • adrenocortical carcinoma
  • health-related quality of life
  • adrenalectomy
  • mitotane
  • chemotherapy
  • CLINICAL-PRACTICE GUIDELINES
  • CUSHINGS-SYNDROME
  • LAPAROSCOPIC ADRENALECTOMY
  • MANAGEMENT
  • DIAGNOSIS
  • RESECTION
  • COMPLICATIONS
  • CHEMOTHERAPY
  • RADIOTHERAPY
  • MULTICENTER

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