Health-related quality of life around the time of diagnosis in patients with bladder cancer

Evan Yi-Wen Yu*, Duncan Nekeman, Lucinda J. Billingham, Nicholas D. James, K. K. Cheng, Richard T. Bryan, Anke Wesselius, Maurice P. Zeegers

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Web of Science)

Abstract

Objectives To quantify the health-related quality of life (HRQoL) of patients with bladder cancer around the time of diagnosis and to test the hypotheses of a two-factor model for the HRQoL questionnaire QLQ-C30. Methods From participants in the Bladder Cancer Prognoses Programme, a multicentre cohort study, sociodemographic data were collected using semi-structured face-to-face interviews. Answers to the QLQ-C30 were transformed into a scale from 0 to 100. HRQoL data were analysed in multivariate analyses. The hypothesized two-factor (Physical and Mental Health) domain structure of the QLQ-C30 was also tested with confirmatory factor analyses (CFA). Results A total of 1160 participants (78%) completed the questionnaire after initial visual diagnosis and before pathological confirmation. Despite non-muscle-invasive bladder cancer (NMIBC) being associated with a higher HRQoL than carcinoma invading bladder muscle, only the domain Role Functioning was clinically significantly better in patients with NMIBC. Age, gender, bladder cancer stage and comorbidity all had a significant influence on QLQ-C30 scores. The CFA showed an overall good fit of the hypothesized two-factor model. Conclusion This study identified a baseline reference value for HRQoL for patients with bladder cancer, which allows better evaluation of any changes in HRQoL as disease progresses or after treatment. In addition, a two-factor (Physical and Mental Health) model was developed for the QLQ-C30.

Original languageEnglish
Pages (from-to)984-991
Number of pages8
JournalBJU International
Volume124
Issue number6
DOIs
Publication statusPublished - Dec 2019

Keywords

  • quality of life
  • time of diagnosis
  • cohort study
  • QLQ-C30 questionnaire
  • #BladderCancer
  • #blcsm
  • EUROPEAN-ORGANIZATION
  • UROTHELIAL CARCINOMA
  • EORTC QLQ-C30
  • STAGE
  • IMPACT
  • QUESTIONNAIRE
  • PROGRESSION
  • ASSOCIATION
  • RECURRENCE
  • RISK

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