Health-related quality of life and cost-effectiveness analysis of gum chewing in patients undergoing colorectal surgery: results of a randomized controlled trial

Madhuri Pattamatta, Boudewijn J. J. Smeets, Silvia M. A. A. Evers, Harm J. T. Rutten, Misha D. P. Luyer, Mickael Hiligsmann*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Web of Science)

Abstract

Background: Postoperative ileus (POI) and anastomotic leakage (AL) following colorectal surgery severely increase healthcare costs and decrease quality of life. This study evaluates the effects of reducing POI and AL via perioperative gum chewing compared to placebo (control) on in-hospital costs, health-related quality of life (HRQoL), and assesses cost-effectiveness. Methods: In patients undergoing elective, open colorectal surgery, changes in HRQoL were assessed using EORTC-QLQ-C30 questionnaires and costs were estimated from a hospital perspective. Incremental cost-effectiveness ratios were estimated. Results: In 112 patients, mean costs for ward stay were significantly lower in the gum chewing group when compared to control ((sic)3522 (95% CI (sic)3034-(sic)4010) versus (sic)4893 (95% CI (sic)3843-(sic)5942), respectively, p = .020). No differences were observed in mean overall in-hospital costs, or in mean change in any of the HRQoL scores or utilities. Gum chewing was dominant (less costly and more effective) compared to the control in more than 50% of the simulations for both POI and AL. Conclusion: Reducing POI and AL via gum chewing reduced costs for ward stay, but did not affect overall in-hospital costs, HRQoL, or mapped utilities. More studies with adequate sample sizes using validated questionnaires at standardized time points are needed.
Original languageEnglish
Pages (from-to)299-306
Number of pages8
JournalActa Chirurgica Belgica
Volume118
Issue number5
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Colorectal surgery
  • postoperative ileus
  • anastomotic leakage
  • cost-effectiveness
  • quality of life
  • POSTOPERATIVE ILEUS
  • CANCER SURGERY
  • ANASTOMOTIC LEAKAGE
  • CLINICAL-TRIAL
  • COMPLICATIONS
  • IMPACT
  • HOSPITALS
  • BURDEN

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