Health hazards associated with wheat and gluten consumption in susceptible individuals and status of research on dietary therapies

Wheat accounts for about 20% to over 50% of the total calorie intake of food in regions where it is grown. However, there is a clear perception that disorders related to the consumption wheat are increasing, particularly in Western Europe, North America, and Australia. We consider here the evidence for this perception and discuss strategies and therapies that may be used to reduce the adverse impacts of wheat on the health of susceptible individuals. First, we will introduce the major groups of wheat grain proteins, focusing on those associated with adverse reactions, and discuss in detail the three major adverse reactions triggered by wheat consumption, namely celiac disease, wheat allergy, and non-celiac gluten/wheat sensitivity. Finally, will discuss other issues associated with the consumption of gluten-free foods focusing on gluten contamination of products purported to be gluten-free, gluten threshold or tolerance among celiac patients, and food labeling.