Head-and-neck paragangliomas are associated with sleep-related complaints, especially in the presence of carotid body tumors

B. Havekes, F. Kastelein, A.A. van der Klaauw, N. Duinen, J.C. Jansen, J.W. Smit, K.W. van Kralingen, A.H. Vriends, J.A. Romijn, E.P. Corssmit

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Abstract

The carotid body functions as a chemoreceptor. We hypothesized that head-and-neck paragangliomas (HNP) may disturb the function of these peripheral chemoreceptors and play a role in sleep-disordered breathing.

This is a case-control study.

This study was conducted in a tertiary referral center.

We assessed fatigue, sleep, and exercise capacity in 74 HNP patients using three questionnaires (Epworth Sleepiness Scale, St. George Respiratory Questionnaire, and a standard clinical sleep assessment questionnaire). Outcomes were compared to those of age- and sex-matched controls.

Activity, disturbance of psychosocial function, and total score were worse compared to controls (15.4 +/- 18.5 vs. 7.2 +/- 9.9, P = 0.007; 5.3 +/- 10.5 vs. 1.2 +/- 2.6, P = 0.008; and 10.4 +/- 12.9 vs. 5.0 +/- 4.8, P = 0.006, respectively). Patients reported more daytime fatigue, concentration difficulties, and depression (51% vs. 24%, P = 0.006; 31% vs. 10%, P = 0.010; and 19% vs. 2%, P = 0.012). Waking up was reported to be less refreshing in HNP patients (53% vs. 73%, P = 0.038). Dysphonia was a predictor of symptoms, activity, disturbance of psychosocial function, and total scores. Remarkably, the presence of a carotid body tumor was an independent predictor of increased daytime sleepiness (beta = 0.287, P = 0.029). In conclusion, patients with HNP have remarkable sleep-related complaints. Especially the presence of carotid body tumors appears to be associated with increased daytime somnolence.

Original languageEnglish
Pages (from-to)527-534
Number of pages8
JournalSleep and Breathing
Volume16
Issue number2
DOIs
Publication statusPublished - Jun 2012

Keywords

  • Paraganglioma
  • Glomus tumors
  • Carotid body tumor
  • Sleep
  • SDHD mutation
  • GERMLINE MUTATIONS
  • DAYTIME SLEEPINESS
  • APNEA
  • SDHD
  • CHEMORECEPTOR
  • RELIABILITY
  • PREVALENCE
  • MECHANISMS
  • GENE

Cite this

Havekes, B., Kastelein, F., van der Klaauw, A. A., Duinen, N., Jansen, J. C., Smit, J. W., van Kralingen, K. W., Vriends, A. H., Romijn, J. A., & Corssmit, E. P. (2012). Head-and-neck paragangliomas are associated with sleep-related complaints, especially in the presence of carotid body tumors. Sleep and Breathing, 16(2), 527-534. https://doi.org/10.1007/s11325-011-0538-5