HDL cholesterol efflux capacity and cholesteryl ester transfer are associated with body mass, but are not changed by diet-induced weight loss: A randomized trial in abdominally obese men

Charlotte P. J. Talbot*, Jogchum Plat, Peter J. Joris, Maurice Konings, Yvo H. A. M. Kusters, Casper G. Schalkwijk, Andreas Ritsch, Ronald P. Mensink

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Web of Science)

Abstract

Background and aims: Obesity is associated with a lower HDL-mediated cholesterol efflux from macrophages and a higher CETP (cholesteryl ester transfer protein) activity, but effects of weight loss are not clear. In addition, associations with visceral and subcutaneous adipose tissue are not known. We therefore investigated effects of diet-induced weight loss on HDL-mediated cholesterol efflux and cholesterol ester (CE) transfer in abdominally obese men. Differences between normal-weight and abdominally obese men were also examined.

Methods: Twenty-five apparently healthy, normal-weight men (waist circumference:

Results: Cholesterol efflux capacity was 9 percentage point (pp) lower in abdominally obese than in normal-weight men (p

Conclusions: After a 2-week weight-stable period, dietary weight loss of 10 kg did not improve ABCA1-mediated cholesterol efflux and CE transfer in abdominally obese men. (C) 2018 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)23-28
Number of pages6
JournalAtherosclerosis
Volume274
DOIs
Publication statusPublished - Jul 2018

Keywords

  • High-density lipoprotein
  • Abdominal obesity
  • Diet-induced weight loss
  • Cholesterol efflux
  • CETP-Activity
  • DENSITY-LIPOPROTEIN CHOLESTEROL
  • TRANSFER PROTEIN CETP
  • C-REACTIVE PROTEIN
  • MESSENGER-RNA
  • NORMOLIPIDEMIC SUBJECTS
  • INSULIN-RESISTANCE
  • ADIPOSE-TISSUE
  • PLASMA
  • WOMEN
  • REDUCTION

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