Harmonizing neuropsychological assessment for mild neurocognitive disorders in Europe

Marina Boccardi; Andreas U. Monsch; Clarissa Ferrari; Daniele Altomare; Manfred Berres; Isabelle Bos; Andreas Buchmann; Chiara Cerami; Mira Didic; Cristina Festari; Valentina Nicolosi; Leonardo Sacco; Liesbeth Aerts; Emiliano Albanese; Jean-Marie Annoni; Nicola Ballhausen; Christian Chicherio; Jean-Francois Demonet; Virginie Descloux; Suzie Diener; Daniel Ferreira; Jean Georges; Anton Gietl; Nicola Girtler; Ingo Kilimann; Stefan Kloppel; Nicole Kustyniuk; Patrizia Mecocci; Nathalie Mella; Martina Pigliautile; Katrin Seeher; Steven D. Shirk; Alessio Toraldo; Andrea Brioschi-Guevara; Kwun C. G. Chan; Paul K. Crane; Alessandra Dodich; Alice Grazia; Nicole A. Kochan; Fabricio Ferreira de Oliveira; Flavio Nobili; Walter Kukull; Oliver Peters; Inez Ramakers; Perminder S. Sachdev; Stefan Teipel; Pieter Jelle Visser; Michael Wagner; Sandra Weintraub; Eric Westman; Consortium for the Harmonization of Neuropsychological Assessment for Neurocognitive Disorders

doi:10.1002/alz.12365

Harmonizing neuropsychological assessment for mild neurocognitive disorders in Europe

Marina Boccardi^*, Andreas U. Monsch, Clarissa Ferrari, Daniele Altomare, Manfred Berres, Isabelle Bos, Andreas Buchmann, Chiara Cerami, Mira Didic, Cristina Festari, Valentina Nicolosi, Leonardo Sacco, Liesbeth Aerts, Emiliano Albanese, Jean-Marie Annoni, Nicola Ballhausen, Christian Chicherio, Jean-Francois Demonet, Virginie Descloux, Suzie DienerDaniel Ferreira, Jean Georges, Anton Gietl, Nicola Girtler, Ingo Kilimann, Stefan Kloppel, Nicole Kustyniuk, Patrizia Mecocci, Nathalie Mella, Martina Pigliautile, Katrin Seeher, Steven D. Shirk, Alessio Toraldo, Andrea Brioschi-Guevara, Kwun C. G. Chan, Paul K. Crane, Alessandra Dodich, Alice Grazia, Nicole A. Kochan, Fabricio Ferreira de Oliveira, Flavio Nobili, Walter Kukull, Oliver Peters, Inez Ramakers, Perminder S. Sachdev, Stefan Teipel, Pieter Jelle Visser, Michael Wagner, Sandra Weintraub, Eric Westman, Consortium for the Harmonization of Neuropsychological Assessment for Neurocognitive Disorders

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Introduction Harmonized neuropsychological assessment for neurocognitive disorders, an international priority for valid and reliable diagnostic procedures, has been achieved only in specific countries or research contexts.Methods To harmonize the assessment of mild cognitive impairment in Europe, a workshop (Geneva, May 2018) convened stakeholders, methodologists, academic, and non-academic clinicians and experts from European, US, and Australian harmonization initiatives.Results With formal presentations and thematic working-groups we defined a standard battery consistent with the U.S. Uniform DataSet, version 3, and homogeneous methodology to obtain consistent normative data across tests and languages. Adaptations consist of including two tests specific to typical Alzheimer's disease and behavioral variant frontotemporal dementia. The methodology for harmonized normative data includes consensus definition of cognitively normal controls, classification of confounding factors (age, sex, and education), and calculation of minimum sample sizes.Discussion This expert consensus allows harmonizing the diagnosis of neurocognitive disorders across European countries and possibly beyond.

Original language	English
Pages (from-to)	29-42
Number of pages	14
Journal	Alzheimer's & Dementia
Volume	18
Issue number	1
Early online date	1 May 2021
DOIs	https://doi.org/10.1002/alz.12365
Publication status	Published - 1 Jan 2022

Keywords

Alzheimer&apos
s disease
cognitive assessment
diagnosis
mild cognitive impairment
mild neurocognitive disorders
standard neuropsychological assessment
SELECTIVE REMINDING TEST
DATA SET UDS
ALZHEIMERS-DISEASE
COGNITIVE IMPAIRMENT
SAMPLE-SIZE
DIFFERENTIAL-DIAGNOSIS
CONSENSUS STATEMENT
BEHAVIORAL VARIANT
AMNESTIC SYNDROME
MONTE-CARLO

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Boccardi, M., Monsch, A. U., Ferrari, C., Altomare, D., Berres, M., Bos, I., Buchmann, A., Cerami, C., Didic, M., Festari, C., Nicolosi, V., Sacco, L., Aerts, L., Albanese, E., Annoni, J.-M., Ballhausen, N., Chicherio, C., Demonet, J.-F., Descloux, V., ... Consortium for the Harmonization of Neuropsychological Assessment for Neurocognitive Disorders (2022). Harmonizing neuropsychological assessment for mild neurocognitive disorders in Europe. Alzheimer's & Dementia, 18(1), 29-42. https://doi.org/10.1002/alz.12365

@article{785a66c6f8ac46bf8d5b89a4047b2d63,

title = "Harmonizing neuropsychological assessment for mild neurocognitive disorders in Europe",

abstract = "Introduction Harmonized neuropsychological assessment for neurocognitive disorders, an international priority for valid and reliable diagnostic procedures, has been achieved only in specific countries or research contexts.Methods To harmonize the assessment of mild cognitive impairment in Europe, a workshop (Geneva, May 2018) convened stakeholders, methodologists, academic, and non-academic clinicians and experts from European, US, and Australian harmonization initiatives.Results With formal presentations and thematic working-groups we defined a standard battery consistent with the U.S. Uniform DataSet, version 3, and homogeneous methodology to obtain consistent normative data across tests and languages. Adaptations consist of including two tests specific to typical Alzheimer's disease and behavioral variant frontotemporal dementia. The methodology for harmonized normative data includes consensus definition of cognitively normal controls, classification of confounding factors (age, sex, and education), and calculation of minimum sample sizes.Discussion This expert consensus allows harmonizing the diagnosis of neurocognitive disorders across European countries and possibly beyond.",

keywords = "Alzheimer&apos, s disease, cognitive assessment, diagnosis, mild cognitive impairment, mild neurocognitive disorders, standard neuropsychological assessment, SELECTIVE REMINDING TEST, DATA SET UDS, ALZHEIMERS-DISEASE, COGNITIVE IMPAIRMENT, SAMPLE-SIZE, DIFFERENTIAL-DIAGNOSIS, CONSENSUS STATEMENT, BEHAVIORAL VARIANT, AMNESTIC SYNDROME, MONTE-CARLO",

author = "Marina Boccardi and Monsch, {Andreas U.} and Clarissa Ferrari and Daniele Altomare and Manfred Berres and Isabelle Bos and Andreas Buchmann and Chiara Cerami and Mira Didic and Cristina Festari and Valentina Nicolosi and Leonardo Sacco and Liesbeth Aerts and Emiliano Albanese and Jean-Marie Annoni and Nicola Ballhausen and Christian Chicherio and Jean-Francois Demonet and Virginie Descloux and Suzie Diener and Daniel Ferreira and Jean Georges and Anton Gietl and Nicola Girtler and Ingo Kilimann and Stefan Kloppel and Nicole Kustyniuk and Patrizia Mecocci and Nathalie Mella and Martina Pigliautile and Katrin Seeher and Shirk, {Steven D.} and Alessio Toraldo and Andrea Brioschi-Guevara and Chan, {Kwun C. G.} and Crane, {Paul K.} and Alessandra Dodich and Alice Grazia and Kochan, {Nicole A.} and {de Oliveira}, {Fabricio Ferreira} and Flavio Nobili and Walter Kukull and Oliver Peters and Inez Ramakers and Sachdev, {Perminder S.} and Stefan Teipel and Visser, {Pieter Jelle} and Michael Wagner and Sandra Weintraub and Eric Westman and {Consortium for the Harmonization of Neuropsychological Assessment for Neurocognitive Disorders}",

year = "2022",

month = jan,

day = "1",

doi = "10.1002/alz.12365",

language = "English",

volume = "18",

pages = "29--42",

journal = "Alzheimer's & Dementia",

issn = "1552-5260",

publisher = "John Wiley & Sons Inc.",

number = "1",

}

Boccardi, M, Monsch, AU, Ferrari, C, Altomare, D, Berres, M, Bos, I, Buchmann, A, Cerami, C, Didic, M, Festari, C, Nicolosi, V, Sacco, L, Aerts, L, Albanese, E, Annoni, J-M, Ballhausen, N, Chicherio, C, Demonet, J-F, Descloux, V, Diener, S, Ferreira, D, Georges, J, Gietl, A, Girtler, N, Kilimann, I, Kloppel, S, Kustyniuk, N, Mecocci, P, Mella, N, Pigliautile, M, Seeher, K, Shirk, SD, Toraldo, A, Brioschi-Guevara, A, Chan, KCG, Crane, PK, Dodich, A, Grazia, A, Kochan, NA, de Oliveira, FF, Nobili, F, Kukull, W, Peters, O, Ramakers, I, Sachdev, PS, Teipel, S, Visser, PJ, Wagner, M, Weintraub, S, Westman, E & Consortium for the Harmonization of Neuropsychological Assessment for Neurocognitive Disorders 2022, 'Harmonizing neuropsychological assessment for mild neurocognitive disorders in Europe', Alzheimer's & Dementia, vol. 18, no. 1, pp. 29-42. https://doi.org/10.1002/alz.12365

TY - JOUR

T1 - Harmonizing neuropsychological assessment for mild neurocognitive disorders in Europe

AU - Boccardi, Marina

AU - Monsch, Andreas U.

AU - Ferrari, Clarissa

AU - Altomare, Daniele

AU - Berres, Manfred

AU - Bos, Isabelle

AU - Buchmann, Andreas

AU - Cerami, Chiara

AU - Didic, Mira

AU - Festari, Cristina

AU - Nicolosi, Valentina

AU - Sacco, Leonardo

AU - Aerts, Liesbeth

AU - Albanese, Emiliano

AU - Annoni, Jean-Marie

AU - Ballhausen, Nicola

AU - Chicherio, Christian

AU - Demonet, Jean-Francois

AU - Descloux, Virginie

AU - Diener, Suzie

AU - Ferreira, Daniel

AU - Georges, Jean

AU - Gietl, Anton

AU - Girtler, Nicola

AU - Kilimann, Ingo

AU - Kloppel, Stefan

AU - Kustyniuk, Nicole

AU - Mecocci, Patrizia

AU - Mella, Nathalie

AU - Pigliautile, Martina

AU - Seeher, Katrin

AU - Shirk, Steven D.

AU - Toraldo, Alessio

AU - Brioschi-Guevara, Andrea

AU - Chan, Kwun C. G.

AU - Crane, Paul K.

AU - Dodich, Alessandra

AU - Grazia, Alice

AU - Kochan, Nicole A.

AU - de Oliveira, Fabricio Ferreira

AU - Nobili, Flavio

AU - Kukull, Walter

AU - Peters, Oliver

AU - Ramakers, Inez

AU - Sachdev, Perminder S.

AU - Teipel, Stefan

AU - Visser, Pieter Jelle

AU - Wagner, Michael

AU - Weintraub, Sandra

AU - Westman, Eric

AU - Consortium for the Harmonization of Neuropsychological Assessment for Neurocognitive Disorders

PY - 2022/1/1

Y1 - 2022/1/1

N2 - Introduction Harmonized neuropsychological assessment for neurocognitive disorders, an international priority for valid and reliable diagnostic procedures, has been achieved only in specific countries or research contexts.Methods To harmonize the assessment of mild cognitive impairment in Europe, a workshop (Geneva, May 2018) convened stakeholders, methodologists, academic, and non-academic clinicians and experts from European, US, and Australian harmonization initiatives.Results With formal presentations and thematic working-groups we defined a standard battery consistent with the U.S. Uniform DataSet, version 3, and homogeneous methodology to obtain consistent normative data across tests and languages. Adaptations consist of including two tests specific to typical Alzheimer's disease and behavioral variant frontotemporal dementia. The methodology for harmonized normative data includes consensus definition of cognitively normal controls, classification of confounding factors (age, sex, and education), and calculation of minimum sample sizes.Discussion This expert consensus allows harmonizing the diagnosis of neurocognitive disorders across European countries and possibly beyond.

AB - Introduction Harmonized neuropsychological assessment for neurocognitive disorders, an international priority for valid and reliable diagnostic procedures, has been achieved only in specific countries or research contexts.Methods To harmonize the assessment of mild cognitive impairment in Europe, a workshop (Geneva, May 2018) convened stakeholders, methodologists, academic, and non-academic clinicians and experts from European, US, and Australian harmonization initiatives.Results With formal presentations and thematic working-groups we defined a standard battery consistent with the U.S. Uniform DataSet, version 3, and homogeneous methodology to obtain consistent normative data across tests and languages. Adaptations consist of including two tests specific to typical Alzheimer's disease and behavioral variant frontotemporal dementia. The methodology for harmonized normative data includes consensus definition of cognitively normal controls, classification of confounding factors (age, sex, and education), and calculation of minimum sample sizes.Discussion This expert consensus allows harmonizing the diagnosis of neurocognitive disorders across European countries and possibly beyond.

KW - Alzheimer&apos

KW - s disease

KW - cognitive assessment

KW - diagnosis

KW - mild cognitive impairment

KW - mild neurocognitive disorders

KW - standard neuropsychological assessment

KW - SELECTIVE REMINDING TEST

KW - DATA SET UDS

KW - ALZHEIMERS-DISEASE

KW - COGNITIVE IMPAIRMENT

KW - SAMPLE-SIZE

KW - DIFFERENTIAL-DIAGNOSIS

KW - CONSENSUS STATEMENT

KW - BEHAVIORAL VARIANT

KW - AMNESTIC SYNDROME

KW - MONTE-CARLO

U2 - 10.1002/alz.12365

DO - 10.1002/alz.12365

M3 - Article

SN - 1552-5260

VL - 18

SP - 29

EP - 42

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

IS - 1

ER -

Harmonizing neuropsychological assessment for mild neurocognitive disorders in Europe

Abstract

Keywords

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