Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration

Eric E Smith; Geert Jan Biessels; François De Guio; Frank Erik de Leeuw; Simon Duchesne; Marco Düring; Richard Frayne; M Arfan Ikram; Eric Jouvent; Bradley J MacIntosh; Michael J Thrippleton; Meike W Vernooij; Hieab Adams; Walter H Backes; Lucia Ballerini; Sandra E Black; Christopher Chen; Rod Corriveau; Charles DeCarli; Steven M Greenberg; M Edip Gurol; Michael Ingrisch; Dominic Job; Bonnie Y K Lam; Lenore J Launer; Jennifer Linn; Cheryl R McCreary; Vincent C T Mok; Leonardo Pantoni; G Bruce Pike; Joel Ramirez; Yael D Reijmer; Jose Rafael Romero; Stefan Ropele; Natalia S Rost; Perminder S Sachdev; Christopher J M Scott; Sudha Seshadri; Mukul Sharma; Steven Sourbron; Rebecca M E Steketee; Richard H Swartz; Robert van Oostenbrugge; Matthias van Osch; Sanneke van Rooden; Anand Viswanathan; David Werring; Martin Dichgans; Joanna M Wardlaw

doi:10.1016/j.dadm.2019.01.002

Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration

Eric E Smith^*, Geert Jan Biessels, François De Guio, Frank Erik de Leeuw, Simon Duchesne, Marco Düring, Richard Frayne, M Arfan Ikram, Eric Jouvent, Bradley J MacIntosh, Michael J Thrippleton, Meike W Vernooij, Hieab Adams, Walter H Backes, Lucia Ballerini, Sandra E Black, Christopher Chen, Rod Corriveau, Charles DeCarli, Steven M GreenbergM Edip Gurol, Michael Ingrisch, Dominic Job, Bonnie Y K Lam, Lenore J Launer, Jennifer Linn, Cheryl R McCreary, Vincent C T Mok, Leonardo Pantoni, G Bruce Pike, Joel Ramirez, Yael D Reijmer, Jose Rafael Romero, Stefan Ropele, Natalia S Rost, Perminder S Sachdev, Christopher J M Scott, Sudha Seshadri, Mukul Sharma, Steven Sourbron, Rebecca M E Steketee, Richard H Swartz, Robert van Oostenbrugge, Matthias van Osch, Sanneke van Rooden, Anand Viswanathan, David Werring, Martin Dichgans, Joanna M Wardlaw

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Introduction: Many consequences of cerebrovascular disease are identifiable by magnetic resonance imaging (MRI), but variation in methods limits multicenter studies and pooling of data. The European Union Joint Program on Neurodegenerative Diseases (EU JPND) funded the HARmoNizing Brain Imaging MEthodS for VaScular Contributions to Neurodegeneration (HARNESS) initiative, with a focus on cerebral small vessel disease.

Methods: Surveys, teleconferences, and an in-person workshop were used to identify gaps in knowledge and to develop tools for harmonizing imaging and analysis.

Results: A framework for neuroimaging biomarker development was developed based on validating repeatability and reproducibility, biological principles, and feasibility of implementation. The status of current MRI biomarkers was reviewed. A website was created at www.harness-neuroimaging.org with acquisition protocols, a software database, rating scales and case report forms, and a deidentified MRI repository.

Conclusions: The HARNESS initiative provides resources to reduce variability in measurement in MRI studies of cerebral small vessel disease.

Original language	English
Pages (from-to)	191-204
Number of pages	14
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	11
Issue number	1
DOIs	https://doi.org/10.1016/j.dadm.2019.01.002
Publication status	Published - Dec 2019

Keywords

Cerebrovascular disease
Stroke
Dementia
Magnetic resonance imaging
Radiology

Access to Document

10.1016/j.dadm.2019.01.002Licence: CC BY-NC-ND

Cite this

Smith, E. E., Biessels, G. J., De Guio, F., de Leeuw, F. E., Duchesne, S., Düring, M., Frayne, R., Ikram, M. A., Jouvent, E., MacIntosh, B. J., Thrippleton, M. J., Vernooij, M. W., Adams, H., Backes, W. H., Ballerini, L., Black, S. E., Chen, C., Corriveau, R., DeCarli, C., ... Wardlaw, J. M. (2019). Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 11(1), 191-204. https://doi.org/10.1016/j.dadm.2019.01.002

@article{21d88c50672342848b763b07091970b0,

title = "Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration",

abstract = "Introduction: Many consequences of cerebrovascular disease are identifiable by magnetic resonance imaging (MRI), but variation in methods limits multicenter studies and pooling of data. The European Union Joint Program on Neurodegenerative Diseases (EU JPND) funded the HARmoNizing Brain Imaging MEthodS for VaScular Contributions to Neurodegeneration (HARNESS) initiative, with a focus on cerebral small vessel disease.Methods: Surveys, teleconferences, and an in-person workshop were used to identify gaps in knowledge and to develop tools for harmonizing imaging and analysis.Results: A framework for neuroimaging biomarker development was developed based on validating repeatability and reproducibility, biological principles, and feasibility of implementation. The status of current MRI biomarkers was reviewed. A website was created at www.harness-neuroimaging.org with acquisition protocols, a software database, rating scales and case report forms, and a deidentified MRI repository.Conclusions: The HARNESS initiative provides resources to reduce variability in measurement in MRI studies of cerebral small vessel disease.",

keywords = "Cerebrovascular disease, Stroke, Dementia, Magnetic resonance imaging, Radiology",

author = "Smith, {Eric E} and Biessels, {Geert Jan} and {De Guio}, Fran{\c c}ois and {de Leeuw}, {Frank Erik} and Simon Duchesne and Marco D{\"u}ring and Richard Frayne and Ikram, {M Arfan} and Eric Jouvent and MacIntosh, {Bradley J} and Thrippleton, {Michael J} and Vernooij, {Meike W} and Hieab Adams and Backes, {Walter H} and Lucia Ballerini and Black, {Sandra E} and Christopher Chen and Rod Corriveau and Charles DeCarli and Greenberg, {Steven M} and Gurol, {M Edip} and Michael Ingrisch and Dominic Job and Lam, {Bonnie Y K} and Launer, {Lenore J} and Jennifer Linn and McCreary, {Cheryl R} and Mok, {Vincent C T} and Leonardo Pantoni and Pike, {G Bruce} and Joel Ramirez and Reijmer, {Yael D} and Romero, {Jose Rafael} and Stefan Ropele and Rost, {Natalia S} and Sachdev, {Perminder S} and Scott, {Christopher J M} and Sudha Seshadri and Mukul Sharma and Steven Sourbron and Steketee, {Rebecca M E} and Swartz, {Richard H} and {van Oostenbrugge}, Robert and {van Osch}, Matthias and {van Rooden}, Sanneke and Anand Viswanathan and David Werring and Martin Dichgans and Wardlaw, {Joanna M}",

note = "Funding Information: Funding sources: This work was funded by the European Union Joint Program on Neurodegenerative Diseases (EU JPND). The funder had no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the article for publication. Funding Information: HARNESS was funded by the international Joint Program for Neurodegenerative Diseases initiative to analyze the role of neuroimaging biomarkers in neurodegeneration and dementia. The HARNESS members were invited to participate based on their contributions to cSVD research, including their participation in STRIVE, and to provide a balance of input from different geographic regions and research disciplines. HARNESS included 70 members from 29 institutions in 11 countries, representing disciplines including radiology, biomedical engineering, clinical trials, computer science, epidemiology, medical biophysics, neurology, stroke medicine, and psychiatry. Members were surveyed to identify important needs for harmonizing neuroimaging methods for cSVD and then subdivided into 11 working groups of 6–12 participants representing a range of disciplines, cSVD interests, and location to address these needs. The initiative commenced in July 2016 and culminated in an in-person conference in June 2017. Where appropriate, working groups identified relevant articles through literature searches, expert knowledge, and hand searching articles from reference lists, but formal systematic reviews and creation of evidence tables were considered out of scope. Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = dec,

doi = "10.1016/j.dadm.2019.01.002",

language = "English",

volume = "11",

pages = "191--204",

journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",

issn = "2352-8729",

publisher = "Elsevier BV",

number = "1",

}

Smith, EE, Biessels, GJ, De Guio, F, de Leeuw, FE, Duchesne, S, Düring, M, Frayne, R, Ikram, MA, Jouvent, E, MacIntosh, BJ, Thrippleton, MJ, Vernooij, MW, Adams, H, Backes, WH, Ballerini, L, Black, SE, Chen, C, Corriveau, R, DeCarli, C, Greenberg, SM, Gurol, ME, Ingrisch, M, Job, D, Lam, BYK, Launer, LJ, Linn, J, McCreary, CR, Mok, VCT, Pantoni, L, Pike, GB, Ramirez, J, Reijmer, YD, Romero, JR, Ropele, S, Rost, NS, Sachdev, PS, Scott, CJM, Seshadri, S, Sharma, M, Sourbron, S, Steketee, RME, Swartz, RH, van Oostenbrugge, R, van Osch, M, van Rooden, S, Viswanathan, A, Werring, D, Dichgans, M & Wardlaw, JM 2019, 'Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 11, no. 1, pp. 191-204. https://doi.org/10.1016/j.dadm.2019.01.002

TY - JOUR

T1 - Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration

AU - Smith, Eric E

AU - Biessels, Geert Jan

AU - De Guio, François

AU - de Leeuw, Frank Erik

AU - Duchesne, Simon

AU - Düring, Marco

AU - Frayne, Richard

AU - Ikram, M Arfan

AU - Jouvent, Eric

AU - MacIntosh, Bradley J

AU - Thrippleton, Michael J

AU - Vernooij, Meike W

AU - Adams, Hieab

AU - Backes, Walter H

AU - Ballerini, Lucia

AU - Black, Sandra E

AU - Chen, Christopher

AU - Corriveau, Rod

AU - DeCarli, Charles

AU - Greenberg, Steven M

AU - Gurol, M Edip

AU - Ingrisch, Michael

AU - Job, Dominic

AU - Lam, Bonnie Y K

AU - Launer, Lenore J

AU - Linn, Jennifer

AU - McCreary, Cheryl R

AU - Mok, Vincent C T

AU - Pantoni, Leonardo

AU - Pike, G Bruce

AU - Ramirez, Joel

AU - Reijmer, Yael D

AU - Romero, Jose Rafael

AU - Ropele, Stefan

AU - Rost, Natalia S

AU - Sachdev, Perminder S

AU - Scott, Christopher J M

AU - Seshadri, Sudha

AU - Sharma, Mukul

AU - Sourbron, Steven

AU - Steketee, Rebecca M E

AU - Swartz, Richard H

AU - van Oostenbrugge, Robert

AU - van Osch, Matthias

AU - van Rooden, Sanneke

AU - Viswanathan, Anand

AU - Werring, David

AU - Dichgans, Martin

AU - Wardlaw, Joanna M

N1 - Funding Information: Funding sources: This work was funded by the European Union Joint Program on Neurodegenerative Diseases (EU JPND). The funder had no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the article for publication. Funding Information: HARNESS was funded by the international Joint Program for Neurodegenerative Diseases initiative to analyze the role of neuroimaging biomarkers in neurodegeneration and dementia. The HARNESS members were invited to participate based on their contributions to cSVD research, including their participation in STRIVE, and to provide a balance of input from different geographic regions and research disciplines. HARNESS included 70 members from 29 institutions in 11 countries, representing disciplines including radiology, biomedical engineering, clinical trials, computer science, epidemiology, medical biophysics, neurology, stroke medicine, and psychiatry. Members were surveyed to identify important needs for harmonizing neuroimaging methods for cSVD and then subdivided into 11 working groups of 6–12 participants representing a range of disciplines, cSVD interests, and location to address these needs. The initiative commenced in July 2016 and culminated in an in-person conference in June 2017. Where appropriate, working groups identified relevant articles through literature searches, expert knowledge, and hand searching articles from reference lists, but formal systematic reviews and creation of evidence tables were considered out of scope. Publisher Copyright: © 2019 The Authors

PY - 2019/12

Y1 - 2019/12

N2 - Introduction: Many consequences of cerebrovascular disease are identifiable by magnetic resonance imaging (MRI), but variation in methods limits multicenter studies and pooling of data. The European Union Joint Program on Neurodegenerative Diseases (EU JPND) funded the HARmoNizing Brain Imaging MEthodS for VaScular Contributions to Neurodegeneration (HARNESS) initiative, with a focus on cerebral small vessel disease.Methods: Surveys, teleconferences, and an in-person workshop were used to identify gaps in knowledge and to develop tools for harmonizing imaging and analysis.Results: A framework for neuroimaging biomarker development was developed based on validating repeatability and reproducibility, biological principles, and feasibility of implementation. The status of current MRI biomarkers was reviewed. A website was created at www.harness-neuroimaging.org with acquisition protocols, a software database, rating scales and case report forms, and a deidentified MRI repository.Conclusions: The HARNESS initiative provides resources to reduce variability in measurement in MRI studies of cerebral small vessel disease.

AB - Introduction: Many consequences of cerebrovascular disease are identifiable by magnetic resonance imaging (MRI), but variation in methods limits multicenter studies and pooling of data. The European Union Joint Program on Neurodegenerative Diseases (EU JPND) funded the HARmoNizing Brain Imaging MEthodS for VaScular Contributions to Neurodegeneration (HARNESS) initiative, with a focus on cerebral small vessel disease.Methods: Surveys, teleconferences, and an in-person workshop were used to identify gaps in knowledge and to develop tools for harmonizing imaging and analysis.Results: A framework for neuroimaging biomarker development was developed based on validating repeatability and reproducibility, biological principles, and feasibility of implementation. The status of current MRI biomarkers was reviewed. A website was created at www.harness-neuroimaging.org with acquisition protocols, a software database, rating scales and case report forms, and a deidentified MRI repository.Conclusions: The HARNESS initiative provides resources to reduce variability in measurement in MRI studies of cerebral small vessel disease.

KW - Cerebrovascular disease

KW - Stroke

KW - Dementia

KW - Magnetic resonance imaging

KW - Radiology

U2 - 10.1016/j.dadm.2019.01.002

DO - 10.1016/j.dadm.2019.01.002

M3 - Article

C2 - 30859119

SN - 2352-8729

VL - 11

SP - 191

EP - 204

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

IS - 1

ER -