Haploidentical stem cell transplantation for patients with lymphoma: a position statement from the Lymphoma Working Party-European Society for Blood and Marrow Transplantation

S. Dietrich, P. Dreger, O. Hermine, C. Kyriakou, S. Montoto, S. Robinson, N. Schmitz, H.C. Schouten, A. Sureda, A. Tanase*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Citations (Web of Science)

Abstract

Allogeneic stem cell transplantation (alloSCT) continues to be the only potentially curative treatment for patients with refractory lymphomas or relapsing after autologous stem cell transplantation. Until recently, alloSCT was restricted to patients who had a matched donor, sibling or unrelated. In the past years, substantial progress in haploidentical transplantation (haploSCT) has resulted in a significant increase in the number of patients treated with this procedure, worldwide. Given the fact that an HLA haplo-identical donor can be found within the immediate family for almost any patient, virtually every patient can receive an haploSCT. Another reason to use haploSCT, especially in diseases like lymphomas where the decision to perform an alloSCT is being taken sometimes late in the course of the disease, is the considerable delay to find a matched unrelated donor (MUD), when an HLA-identical sibling (MSD) is not available. In this paper, we summarize available evidence supporting the use of haploSCT in lymphoma patients and share current recommendations of the Lymphoma Working Party of the European Society for Blood and Marrow Transplantation (EBMT) on how to integrate haploSCT in this population.
Original languageEnglish
Pages (from-to)317-324
Number of pages8
JournalBone Marrow Transplantation
Volume55
Issue number2
DOIs
Publication statusPublished - 1 Feb 2020

Keywords

  • cd3/cd19 depletion
  • hematologic malignancies
  • high-risk
  • non-hodgkin-lymphoma
  • outcomes
  • posttransplantation cyclophosphamide
  • reduced-intensity
  • sct
  • therapy
  • unrelated donor transplantation
  • SCT
  • UNRELATED DONOR TRANSPLANTATION
  • CD3/CD19 DEPLETION
  • REDUCED-INTENSITY
  • THERAPY
  • HIGH-RISK
  • POSTTRANSPLANTATION CYCLOPHOSPHAMIDE
  • NON-HODGKIN-LYMPHOMA
  • OUTCOMES
  • HEMATOLOGIC MALIGNANCIES

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