Half-Life Time and Control Frequency of Vitamin K-Dependent Coagulation Factors: Theoretical Considerations on the Place of Factor VII in the Control of Oral Anticoagulation Therapy

M.C.E. van Dam-Mieras; H.C. Hemker

doi:10.1159/000214728

Half-Life Time and Control Frequency of Vitamin K-Dependent Coagulation Factors: Theoretical Considerations on the Place of Factor VII in the Control of Oral Anticoagulation Therapy

M.C.E. van Dam-Mieras, H.C. Hemker

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Abstract

A short review about the place of coagulation factor VII in the initial phase of blood coagulation is given. A theoretical model describing the relationship between the half-life times of vitamin K-dependent coagulation factors and the control frequency of oral anticoagulation therapy is presented. The constraints that control frequency imposes on the type of determination to be carried out are discussed.

Original language	English
Pages (from-to)	201-208
Number of pages	8
Journal	Haemostasis
Volume	13
Issue number	3
DOIs	https://doi.org/10.1159/000214728
Publication status	Published - 1983

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title = "Half-Life Time and Control Frequency of Vitamin K-Dependent Coagulation Factors: Theoretical Considerations on the Place of Factor VII in the Control of Oral Anticoagulation Therapy",

abstract = "A short review about the place of coagulation factor VII in the initial phase of blood coagulation is given. A theoretical model describing the relationship between the half-life times of vitamin K-dependent coagulation factors and the control frequency of oral anticoagulation therapy is presented. The constraints that control frequency imposes on the type of determination to be carried out are discussed.",

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AB - A short review about the place of coagulation factor VII in the initial phase of blood coagulation is given. A theoretical model describing the relationship between the half-life times of vitamin K-dependent coagulation factors and the control frequency of oral anticoagulation therapy is presented. The constraints that control frequency imposes on the type of determination to be carried out are discussed.

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Half-Life Time and Control Frequency of Vitamin K-Dependent Coagulation Factors: Theoretical Considerations on the Place of Factor VII in the Control of Oral Anticoagulation Therapy

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