Half-Life Time and Control Frequency of Vitamin K-Dependent Coagulation Factors: Theoretical Considerations on the Place of Factor VII in the Control of Oral Anticoagulation Therapy

M.C.E. van Dam-Mieras, H.C. Hemker

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    Abstract

    A short review about the place of coagulation factor VII in the initial phase of blood coagulation is given. A theoretical model describing the relationship between the half-life times of vitamin K-dependent coagulation factors and the control frequency of oral anticoagulation therapy is presented. The constraints that control frequency imposes on the type of determination to be carried out are discussed.
    Original languageEnglish
    Pages (from-to)201-208
    Number of pages8
    JournalHaemostasis
    Volume13
    Issue number3
    DOIs
    Publication statusPublished - 1983

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