Growth versus inflammation : lung development after antenatal inflammation and corticosteroids

J.J.P. Collins

Research output: ThesisDoctoral ThesisInternal

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Abstract

In the Western world 5-13% of all children are born early, before 37 weeks of pregnancy duration. Premature birth is often caused by a bacterial infection in the uterus. The most common disorder in these babies is bronchopulmonary dysplasia (BPD), an incurable disorder in the lung growth as a result of which they don’t get sufficient oxygen in their body. So, it is known that uterus infections often lead to the development of BPD, but how this exactly happens is not clear. This dissertation studies how bacterial infections influence the lung development, so that in the future new therapies can be developed to cure or even prevent BPD.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Kramer, Boris, Supervisor
  • Zimmermann, Luc, Supervisor
  • Kallapur, S.G., Supervisor, External person
Award date19 Dec 2012
Place of Publication's-Hertogenbosch
Publisher
Publication statusPublished - 1 Jan 2012

Keywords

  • Premature birth
  • chorioamnionitis
  • bronchopulmonary dysplasia (BPD)
  • antenatal corticosteroids
  • lung development

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