Growth, health, and motor development of 5-year-old children born after preimplantation genetic diagnosis

Malou Heijligers; Andrea Peeters; Aafke van Montfoort; Joyce Nijsten; Etienne Janssen; Femke Klein Gunnewiek; Rick de Rooy; Ron van Golde; Edith Coonen; Madelon Meijer-Hoogeveen; Frank Broekmans; Mark van der Hoeven; Yvonne Arens; Christine de Die-Smulders

doi:10.1016/j.fertnstert.2019.01.035

Growth, health, and motor development of 5-year-old children born after preimplantation genetic diagnosis

Malou Heijligers^*, Andrea Peeters, Aafke van Montfoort, Joyce Nijsten, Etienne Janssen, Femke Klein Gunnewiek, Rick de Rooy, Ron van Golde, Edith Coonen, Madelon Meijer-Hoogeveen, Frank Broekmans, Mark van der Hoeven, Yvonne Arens, Christine de Die-Smulders

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

15 Citations (Web of Science)

Abstract

Objective: To evaluate the growth, health, and motor development of children born after preimplantation genetic diagnosis (PGD).

Design: Observational cohort study and comparison of 5-year-old children born after PGD to similar aged children born after IVF/intracytoplasmic sperm injection (ICSI) and children from families with a genetic disorder born after natural conception (NC).

Setting: University hospital.

Patient(s): One hundred three children were included in the PGD group. The two control groups consisted of 90 children born after IVF/ICSI and 58 children born after NC.

Intervention(s): PGD.

Main Outcome Measure(s): We measured height, weight, body circumferences, body mass index, and blood pressure and performed a dysmorphological and neurological examination. We also collected data about the children's medical history, health care consultations, and motor milestones.

Result(s): The mean height, weight, and body mass index were comparable for all groups. Six (5.8%) PGD, four (4.4%) IVF/ICSI, and five (8.6%) NC children had a major congenital abnormality. The incidence of acute and chronic illnesses was similar in all groups. Motor milestones were achieved on time, but the IVF/ICSI group had a slightly younger mean sitting age. None of the children had severe neurological problems.

Conclusion(s): Five-year-old children born after PGD show normal growth, health, and motor development when compared with children born after IVF/ICSI and NC children from families with a genetic disorder. ((C) 2019 by American Society for Reproductive Medicine.)

Original language	English
Pages (from-to)	1151-1158
Number of pages	8
Journal	Fertility and Sterility
Volume	111
Issue number	6
DOIs	https://doi.org/10.1016/j.fertnstert.2019.01.035
Publication status	Published - Jun 2019

Keywords

Preimplantation genetic diagnosis
preimplantation genetic testing follow-up
child
ASSISTED REPRODUCTIVE TECHNOLOGIES
IN-VITRO FERTILIZATION
PRACTICE GUIDELINES
SINGLETONS BORN
EMBRYO BIOPSY
ESHRE PGD
CONSORTIUM
STRESS

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10.1016/j.fertnstert.2019.01.035

Cite this

Heijligers, M., Peeters, A., van Montfoort, A., Nijsten, J., Janssen, E., Gunnewiek, F. K., de Rooy, R., van Golde, R., Coonen, E., Meijer-Hoogeveen, M., Broekmans, F., van der Hoeven, M., Arens, Y., & de Die-Smulders, C. (2019). Growth, health, and motor development of 5-year-old children born after preimplantation genetic diagnosis. Fertility and Sterility, 111(6), 1151-1158. https://doi.org/10.1016/j.fertnstert.2019.01.035

@article{cc56f10651dd427ca0a5f7b95cf437c6,

title = "Growth, health, and motor development of 5-year-old children born after preimplantation genetic diagnosis",

abstract = "Objective: To evaluate the growth, health, and motor development of children born after preimplantation genetic diagnosis (PGD).Design: Observational cohort study and comparison of 5-year-old children born after PGD to similar aged children born after IVF/intracytoplasmic sperm injection (ICSI) and children from families with a genetic disorder born after natural conception (NC).Setting: University hospital.Patient(s): One hundred three children were included in the PGD group. The two control groups consisted of 90 children born after IVF/ICSI and 58 children born after NC.Intervention(s): PGD.Main Outcome Measure(s): We measured height, weight, body circumferences, body mass index, and blood pressure and performed a dysmorphological and neurological examination. We also collected data about the children's medical history, health care consultations, and motor milestones.Result(s): The mean height, weight, and body mass index were comparable for all groups. Six (5.8%) PGD, four (4.4%) IVF/ICSI, and five (8.6%) NC children had a major congenital abnormality. The incidence of acute and chronic illnesses was similar in all groups. Motor milestones were achieved on time, but the IVF/ICSI group had a slightly younger mean sitting age. None of the children had severe neurological problems.Conclusion(s): Five-year-old children born after PGD show normal growth, health, and motor development when compared with children born after IVF/ICSI and NC children from families with a genetic disorder. ((C) 2019 by American Society for Reproductive Medicine.)",

keywords = "Preimplantation genetic diagnosis, preimplantation genetic testing follow-up, child, ASSISTED REPRODUCTIVE TECHNOLOGIES, IN-VITRO FERTILIZATION, PRACTICE GUIDELINES, SINGLETONS BORN, EMBRYO BIOPSY, ESHRE PGD, CONSORTIUM, STRESS",

author = "Malou Heijligers and Andrea Peeters and {van Montfoort}, Aafke and Joyce Nijsten and Etienne Janssen and Gunnewiek, {Femke Klein} and {de Rooy}, Rick and {van Golde}, Ron and Edith Coonen and Madelon Meijer-Hoogeveen and Frank Broekmans and {van der Hoeven}, Mark and Yvonne Arens and {de Die-Smulders}, Christine",

year = "2019",

month = jun,

doi = "10.1016/j.fertnstert.2019.01.035",

language = "English",

volume = "111",

pages = "1151--1158",

journal = "Fertility and Sterility",

issn = "0015-0282",

publisher = "Elsevier Science",

number = "6",

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Heijligers, M, Peeters, A, van Montfoort, A, Nijsten, J, Janssen, E, Gunnewiek, FK, de Rooy, R, van Golde, R , Coonen, E, Meijer-Hoogeveen, M, Broekmans, F, van der Hoeven, M, Arens, Y & de Die-Smulders, C 2019, 'Growth, health, and motor development of 5-year-old children born after preimplantation genetic diagnosis', Fertility and Sterility, vol. 111, no. 6, pp. 1151-1158. https://doi.org/10.1016/j.fertnstert.2019.01.035

TY - JOUR

T1 - Growth, health, and motor development of 5-year-old children born after preimplantation genetic diagnosis

AU - Heijligers, Malou

AU - Peeters, Andrea

AU - van Montfoort, Aafke

AU - Nijsten, Joyce

AU - Janssen, Etienne

AU - Gunnewiek, Femke Klein

AU - de Rooy, Rick

AU - van Golde, Ron

AU - Coonen, Edith

AU - Meijer-Hoogeveen, Madelon

AU - Broekmans, Frank

AU - van der Hoeven, Mark

AU - Arens, Yvonne

AU - de Die-Smulders, Christine

PY - 2019/6

Y1 - 2019/6

N2 - Objective: To evaluate the growth, health, and motor development of children born after preimplantation genetic diagnosis (PGD).Design: Observational cohort study and comparison of 5-year-old children born after PGD to similar aged children born after IVF/intracytoplasmic sperm injection (ICSI) and children from families with a genetic disorder born after natural conception (NC).Setting: University hospital.Patient(s): One hundred three children were included in the PGD group. The two control groups consisted of 90 children born after IVF/ICSI and 58 children born after NC.Intervention(s): PGD.Main Outcome Measure(s): We measured height, weight, body circumferences, body mass index, and blood pressure and performed a dysmorphological and neurological examination. We also collected data about the children's medical history, health care consultations, and motor milestones.Result(s): The mean height, weight, and body mass index were comparable for all groups. Six (5.8%) PGD, four (4.4%) IVF/ICSI, and five (8.6%) NC children had a major congenital abnormality. The incidence of acute and chronic illnesses was similar in all groups. Motor milestones were achieved on time, but the IVF/ICSI group had a slightly younger mean sitting age. None of the children had severe neurological problems.Conclusion(s): Five-year-old children born after PGD show normal growth, health, and motor development when compared with children born after IVF/ICSI and NC children from families with a genetic disorder. ((C) 2019 by American Society for Reproductive Medicine.)

AB - Objective: To evaluate the growth, health, and motor development of children born after preimplantation genetic diagnosis (PGD).Design: Observational cohort study and comparison of 5-year-old children born after PGD to similar aged children born after IVF/intracytoplasmic sperm injection (ICSI) and children from families with a genetic disorder born after natural conception (NC).Setting: University hospital.Patient(s): One hundred three children were included in the PGD group. The two control groups consisted of 90 children born after IVF/ICSI and 58 children born after NC.Intervention(s): PGD.Main Outcome Measure(s): We measured height, weight, body circumferences, body mass index, and blood pressure and performed a dysmorphological and neurological examination. We also collected data about the children's medical history, health care consultations, and motor milestones.Result(s): The mean height, weight, and body mass index were comparable for all groups. Six (5.8%) PGD, four (4.4%) IVF/ICSI, and five (8.6%) NC children had a major congenital abnormality. The incidence of acute and chronic illnesses was similar in all groups. Motor milestones were achieved on time, but the IVF/ICSI group had a slightly younger mean sitting age. None of the children had severe neurological problems.Conclusion(s): Five-year-old children born after PGD show normal growth, health, and motor development when compared with children born after IVF/ICSI and NC children from families with a genetic disorder. ((C) 2019 by American Society for Reproductive Medicine.)

KW - Preimplantation genetic diagnosis

KW - preimplantation genetic testing follow-up

KW - child

KW - ASSISTED REPRODUCTIVE TECHNOLOGIES

KW - IN-VITRO FERTILIZATION

KW - PRACTICE GUIDELINES

KW - SINGLETONS BORN

KW - EMBRYO BIOPSY

KW - ESHRE PGD

KW - CONSORTIUM

KW - STRESS

U2 - 10.1016/j.fertnstert.2019.01.035

DO - 10.1016/j.fertnstert.2019.01.035

M3 - Article

C2 - 31005312

VL - 111

SP - 1151

EP - 1158

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 6

ER -