Growth, health, and motor development of 5-year-old children born after preimplantation genetic diagnosis

Malou Heijligers*, Andrea Peeters, Aafke van Montfoort, Joyce Nijsten, Etienne Janssen, Femke Klein Gunnewiek, Rick de Rooy, Ron van Golde, Edith Coonen, Madelon Meijer-Hoogeveen, Frank Broekmans, Mark van der Hoeven, Yvonne Arens, Christine de Die-Smulders

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Web of Science)

Abstract

Objective: To evaluate the growth, health, and motor development of children born after preimplantation genetic diagnosis (PGD).

Design: Observational cohort study and comparison of 5-year-old children born after PGD to similar aged children born after IVF/intracytoplasmic sperm injection (ICSI) and children from families with a genetic disorder born after natural conception (NC).

Setting: University hospital.

Patient(s): One hundred three children were included in the PGD group. The two control groups consisted of 90 children born after IVF/ICSI and 58 children born after NC.

Intervention(s): PGD.

Main Outcome Measure(s): We measured height, weight, body circumferences, body mass index, and blood pressure and performed a dysmorphological and neurological examination. We also collected data about the children's medical history, health care consultations, and motor milestones.

Result(s): The mean height, weight, and body mass index were comparable for all groups. Six (5.8%) PGD, four (4.4%) IVF/ICSI, and five (8.6%) NC children had a major congenital abnormality. The incidence of acute and chronic illnesses was similar in all groups. Motor milestones were achieved on time, but the IVF/ICSI group had a slightly younger mean sitting age. None of the children had severe neurological problems.

Conclusion(s): Five-year-old children born after PGD show normal growth, health, and motor development when compared with children born after IVF/ICSI and NC children from families with a genetic disorder. ((C) 2019 by American Society for Reproductive Medicine.)

Original languageEnglish
Pages (from-to)1151-1158
Number of pages8
JournalFertility and Sterility
Volume111
Issue number6
DOIs
Publication statusPublished - Jun 2019

Keywords

  • Preimplantation genetic diagnosis
  • preimplantation genetic testing follow-up
  • child
  • ASSISTED REPRODUCTIVE TECHNOLOGIES
  • IN-VITRO FERTILIZATION
  • PRACTICE GUIDELINES
  • SINGLETONS BORN
  • EMBRYO BIOPSY
  • ESHRE PGD
  • CONSORTIUM
  • STRESS

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