Grow with the Flow: When Morphogenesis Meets Microfluidics

Research output: Contribution to journalArticleAcademicpeer-review

28 Citations (Web of Science)

Abstract

Developmental biology has advanced the understanding of the intricate and dynamic processes involved in the formation of an organism from a single cell. However, many gaps remain in the knowledge of embryonic development, especially regarding tissue morphogenesis. A possible approach to mimic such phenomena uses pluripotent stem cells in in vitro morphogenetic models. Herein, these systems are summarized with emphasis on the ability to better manipulate and control cellular interfaces with either liquid or solid materials using microengineered tools, which is critical for attaining deeper insights into pattern formation and stem cell differentiation during organogenesis. The role of conventional and customized cell-culture systems in supporting important advances in the field of morphogenesis is discussed, and the fascinating role that material sciences and microengineering currently play and are expected to play in the future is highlighted. In conclusion, it is proffered that continued microfluidics innovations when applied to morphogenesis promise to provide important insights to advance many multidisciplinary fields, including regenerative medicine.

Original languageEnglish
Article number1805764
Number of pages17
JournalAdvanced Materials
Volume31
Issue number17
DOIs
Publication statusPublished - 25 Apr 2019

Keywords

  • artificial organogenesis
  • cell-material interactions
  • microfluidics
  • morphogenetic microengineering
  • pluripotent stem cells
  • EMBRYONIC STEM-CELLS
  • IN-VITRO MODEL
  • ON-A-CHIP
  • SELF-ORGANIZATION
  • GENE-EXPRESSION
  • POSITIONAL INFORMATION
  • DEVELOPMENTAL BIOLOGY
  • CULTURE-CONDITIONS
  • SOFT LITHOGRAPHY
  • AXIS FORMATION

Cite this