Gray matter network reorganization in multiple sclerosis from 7-Tesla and 3-Tesla MRI data

Gabriel Gonzalez-Escamilla, Dumitru Ciolac, Silvia De Santis, Angela Radetz, Vinzenz Fleischer, Amgad Droby, Alard Roebroeck, Sven G. Meuth, Muthuraman Muthuraman, Sergiu Groppa*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective: The objective of this study was to determine the ability of 7T‐MRI for characterizing brain tissue integrity in early relapsing‐remitting MS patients compared to conventional 3T‐MRI and to investigate whether 7T‐MRI improves the performance for detecting cortical gray matter neurodegeneration and its associated network reorganization dynamics.
Methods: Seven early relapsing‐remitting MS patients and seven healthy individuals received MRI at 7T and 3T, whereas 30 and 40 healthy controls underwent separate 3T‐ and 7T‐MRI sessions, respectively. Surface‐based cortical thickness (CT) and gray‐to‐white contrast (GWc) measures were used to model morphometric networks, analyzed with graph theory by means of modularity, clustering coefficient, path length, and small‐worldness.
Results: 7T‐MRI had lower CT and higher GWc compared to 3T‐MRI in MS. CT and GWc measures robustly differentiated MS from controls at 3T‐MRI. 7T‐ and 3T‐MRI showed high regional correspondence for CT (r = 0.72, P = 2e‐78) and GWc (r = 0.83, P = 5.5e‐121) in MS patients. MS CT and GWc morphometric networks at 7T‐MRI showed higher modularity, clustering coefficient, and small‐worldness than 3T, also compared to controls.
Interpretation: 7T‐MRI allows to more precisely quantify morphometric alterations across the cortical mantle and captures more sensitively MS‐related network reorganization. Our findings open new avenues to design more accurate studies quantifying brain tissue loss and test treatment effects on tissue repair.
Original languageEnglish
Pages (from-to)543-553
Number of pages11
JournalAnnals of Clinical and Translational Neurology
Volume7
Issue number4
DOIs
Publication statusPublished - 7 Apr 2020

Keywords

  • 3 T
  • ATROPHY
  • CHALLENGES
  • DISABILITY
  • DYNAMICS

Cite this

Gonzalez-Escamilla, G., Ciolac, D., De Santis, S., Radetz, A., Fleischer, V., Droby, A., Roebroeck, A., Meuth, S. G., Muthuraman, M., & Groppa, S. (2020). Gray matter network reorganization in multiple sclerosis from 7-Tesla and 3-Tesla MRI data. Annals of Clinical and Translational Neurology, 7(4), 543-553. https://doi.org/10.1002/acn3.51029