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Granzyme A impairs host defense during Streptococcus pneumoniae pneumonia
Florry E. van den Boogaard
*
, Klaas P. J. M. van Gisbergen
,
Juanita H. Vernooy
, Jan P. Medema
, Joris J. T. H. Roelofs
, Marieke A. D. van Zoelen
, Henrik Endeman
, Douwe H. Biesma
,
Louis Boon
, Cornelis van't Veer
, Alex F. de Vos
, Tom van der Poll
*
Corresponding author for this work
Pulmonologie
University College Maastricht
Research output
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peer-review
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INIS
pneumonia
100%
defense
100%
host
100%
streptococcus
100%
mice
41%
communities
33%
natural killer cells
33%
lungs
25%
patients
25%
fluids
25%
lavage
25%
antibodies
8%
levels
8%
humans
8%
tissues
8%
control
8%
comparative evaluations
8%
pathogens
8%
inoculation
8%
serine
8%
Keyphrases
Streptococcus Pneumoniae
100%
Host Defense
100%
Granzyme
100%
Community-acquired Pneumonia
33%
Natural Killer Cells
33%
Bronchoalveolar Lavage Fluid
25%
Pneumonia Patients
25%
S. Pneumoniae
16%
Pneumonia
8%
Gene-deficient Mice
8%
Lung
8%
Immune Response
8%
Causative Pathogen
8%
Lung Tissue
8%
Wild Mice
8%
Parenchymal Cells
8%
Host Response
8%
Bacterial Count
8%
Tissue Slide
8%
Cell Depletion
8%
Serine Protease
8%
Bacterial Load
8%
Non-parenchymal Cells
8%
Body Sites
8%
Intranasal Inoculation
8%
Human Lung
8%
Immunology and Microbiology
Host Resistance
100%
Granzyme
100%
Streptococcus Pneumonia
100%
Natural Killer Cell
33%
Wild Type
25%
Bronchoalveolar Lavage Fluid
25%
Immune Response
16%
Pneumococcus
16%
Infectious Agent
8%
Wild Type Mouse
8%
Bacterial Count
8%
Bacterial Load
8%
Serine
8%