Grain and dietary fiber intake and bladder cancer risk: a pooled analysis of prospective cohort studies

Evan Y. W. Yu, Anke Wesselius*, Siamak Mehrkanoon, Maree Brinkman, Piet van den Brandt, Emily White, Elisabete Weiderpass, Florence Le Calvez-Kelm, Marc Gunter, Inge Huybrechts, Fredrik Liedberg, Guri Skeie, Anne Tjonneland, Elio Riboli, Graham G. Giles, Roger L. Milne, Maurice P. Zeegers

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Web of Science)


Background: Higher intakes of whole grains and dietary fiber have been associated with lower risk of insulin resistance. hyperinsulinemia, and inflammation, which are known predisposing factors for cancer.

Objectives: Because the evidence of association with bladder cancer (BC) is limited, we aimed to assess associations with BC risk for intakes of whole grains, refined grains, and dietary fiber.

Methods: We pooled individual data from 574,726 participants in 13 cohort studies, 3214 of whom developed incident BC. HRs, with corresponding 95% CIs. were estimated using Cox regression models stratified on cohort. Dose-response relations were examined using fractional polynomial regression models.

Results: We found that higher intake of total whole grain was associated with lower risk of BC (comparing highest with lowest intake tertile: HR: 0.87; 95% CI: 0.77, 0.98; HR per 1-SD increment: 0.95; 95% CI: 0.91, 0.99; P for trend: 0.023). No association was observed for intake of total refined grain. Intake of total dietary fiber was also inversely associated with BC risk (comparing highest with lowest intake tertile: HR: 0.86; 95% CI: 0.76, 0.98; HR per 1-SD increment: 0.91: 95% CI: P for trend: 0.021). In addition. dose-response analyses gave estimated HRs of 0.97 (95% CI: 0.95, 0.99) for intake of total whole grain and 0.96 (95% CI: 0.94, 0.98) for intake of total dietary fiber per 5-g daily increment. When considered jointly, highest intake of whole grains with the highest intake of dietary fiber showed 28% reduced risk (95% CI: 0.54, 0.93; P for trend: 0.031) of BC compared with the lowest intakes, suggesting potential synergism.

Conclusions: Higher intakes of total whole grain and total dietary fiber are associated with reduced risk of BC individually and jointly. Further studies are needed to clarify the underlying mechanisms for these findings.

Original languageEnglish
Pages (from-to)1252-1266
Number of pages15
JournalAmerican Journal of Clinical Nutrition
Issue number5
Publication statusPublished - Nov 2020


  • bladder cancer
  • grain
  • dietary fiber
  • dose-response analysis
  • cohort study
  • US MEN

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