Grading der Tumorregression gastrointestinaler Karzinome nach neoadjuvanter Therapie

D. Liu, R. Langer*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Web of Science)

Abstract

Pre- or perioperative chemo- or radiochemotherapy and subsequent resection is the standard therapy for locally advanced esophageal, gastric, and rectal cancer. A tumor regression grading (TRG; also tumor regression grade) categorizes the extent of the regressive changes after a neoadjuvant treatment. There are several TRG systems for gastrointestinal carcinomas that relate either to the extent of the therapy-induced fibrosis in relation to the residual tumor or the estimated proportion of the residual tumor in the area of the former tumor area. An ideal TRG system shows significant interobserver agreement and offers relevant prognostic information - in most cases a complete or almost complete regression after neoadjuvant therapy is associated with an improved prognosis. In this review, the most commonly used TRG systems for gastrointestinal carcinomas are presented and discussed. In addition, current issues such as the standardization of TRG and the subject of regression in lymph node metastases in the context of a TRG system are discussed.
Original languageGerman
Pages (from-to)51-56
Number of pages6
JournalPathologe
Volume43
Issue number1
Early online date23 Dec 2021
DOIs
Publication statusPublished - Feb 2022

Keywords

  • Gastrointestinal neoplasms
  • Histopathology
  • Tumor regression grading
  • Observer variation
  • Reference standards
  • AMERICAN-JOINT-COMMITTEE
  • PREOPERATIVE CHEMORADIOTHERAPY
  • RECTAL-CANCER
  • ESOPHAGEAL ADENOCARCINOMAS
  • PERIOPERATIVE CHEMOTHERAPY
  • RADIOCHEMOTHERAPY
  • PROGNOSIS
  • SURGERY
  • SYSTEM

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