Glycated Hemoglobin Measurement and Prediction of Cardiovascular Disease

Emanuele Di Angelantonio; Pei Gao; Hassan Khan; Adam S. Butterworth; David Wormser; Stephen Kaptoge; Sreenivasa Rao Kondapally Seshasai; Alex Thompson; Nadeem Sarwar; Peter Willeit; Paul M. Ridker; Elizabeth L. M. Barr; Kay-Tee Khaw; Bruce M. Psaty; Hermann Brenner; Beverley Balkau; Jacqueline M. Dekker; Debbie A. Lawlor; Makoto Daimon; Johann Willeit; Inger Njolstad; Aulikki Nissinen; Eric J. Brunner; Lewis H. Kuller; Jackie F. Price; Johan Sundstrom; Matthew W. Knuiman; Edith J. M. Feskens; W. M. M. Verschuren; Nicholas Wald; Stephan J. L. Bakker; Peter H. Whincup; Ian Ford; Uri Goldbourt; Agustin Gomez-de-la-Camara; John Gallacher; Leon A. Simons; Annika Rosengren; Susan E. Sutherland; Cecilia Bjorkelund; Dan G. Blazer; Sylvia Wassertheil-Smoller; Altan Onat; Alejandro Marin Ibanez; Edoardo Casiglia; J. Wouter Jukema; Lara M. Simpson; Simona Giampaoli; Borge G. Nordestgaard; Randi Selmer; Patrik Wennberg; Jussi Kauhanen; Jukka T. Salonen; Rachel Dankner; Elizabeth Barrett-Connor; Maryam Kavousi; Vilmundur Gudnason; Denis Evans; Robert B. Wallace; Mary Cushman; Ralph B., Sr. D'Agostino; Jason G. Umans; Yutaka Kiyohara; Hidaeki Nakagawa; Shinichi Sato; Richard F. Gillum; Aaron R. Folsom; Yvonne T. van der Schouw; Karel G. Moons; Simon J. Griffin; Naveed Sattar; Nicholas J. Wareham; Elizabeth Selvin; Simon G. Thompson; Emerging Risk Factors Collaboration; Coen Stehouwer; John Danesh

doi:10.1001/jama.2014.1873

Glycated Hemoglobin Measurement and Prediction of Cardiovascular Disease

Emanuele Di Angelantonio, Pei Gao, Hassan Khan, Adam S. Butterworth, David Wormser, Stephen Kaptoge, Sreenivasa Rao Kondapally Seshasai, Alex Thompson, Nadeem Sarwar, Peter Willeit, Paul M. Ridker, Elizabeth L. M. Barr, Kay-Tee Khaw, Bruce M. Psaty, Hermann Brenner, Beverley Balkau, Jacqueline M. Dekker, Debbie A. Lawlor, Makoto Daimon, Johann WilleitInger Njolstad, Aulikki Nissinen, Eric J. Brunner, Lewis H. Kuller, Jackie F. Price, Johan Sundstrom, Matthew W. Knuiman, Edith J. M. Feskens, W. M. M. Verschuren, Nicholas Wald, Stephan J. L. Bakker, Peter H. Whincup, Ian Ford, Uri Goldbourt, Agustin Gomez-de-la-Camara, John Gallacher, Leon A. Simons, Annika Rosengren, Susan E. Sutherland, Cecilia Bjorkelund, Dan G. Blazer, Sylvia Wassertheil-Smoller, Altan Onat, Alejandro Marin Ibanez, Edoardo Casiglia, J. Wouter Jukema, Lara M. Simpson, Simona Giampaoli, Borge G. Nordestgaard, Randi Selmer, Patrik Wennberg, Jussi Kauhanen, Jukka T. Salonen, Rachel Dankner, Elizabeth Barrett-Connor, Maryam Kavousi, Vilmundur Gudnason, Denis Evans, Robert B. Wallace, Mary Cushman, Ralph B., Sr. D'Agostino, Jason G. Umans, Yutaka Kiyohara, Hidaeki Nakagawa, Shinichi Sato, Richard F. Gillum, Aaron R. Folsom, Yvonne T. van der Schouw, Karel G. Moons, Simon J. Griffin, Naveed Sattar, Nicholas J. Wareham, Elizabeth Selvin, Simon G. Thompson, Emerging Risk Factors Collaboration, Coen Stehouwer, John Danesh^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The value of measuring levels of glycated hemoglobin (HbA1c) for the prediction of first cardiovascular events is uncertain.To determine whether adding information on HbA1c values to conventional cardiovascular risk factors is associated with improvement in prediction of cardiovascular disease (CVD) risk.Analysis of individual-participant data available from 73 prospective studies involving 294,998 participants without a known history of diabetes mellitus or CVD at the baseline assessment.Measures of risk discrimination for CVD outcomes (eg, C-index) and reclassification (eg, net reclassification improvement) of participants across predicted 10-year risk categories of low (

Original language	English
Pages (from-to)	1225-1233
Journal	JAMA-Journal of the American Medical Association
Volume	311
Issue number	12
DOIs	https://doi.org/10.1001/jama.2014.1873
Publication status	Published - 26 Mar 2014

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10.1001/jama.2014.1873

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Di Angelantonio, E., Gao, P., Khan, H., Butterworth, A. S., Wormser, D., Kaptoge, S., Seshasai, S. R. K., Thompson, A., Sarwar, N., Willeit, P., Ridker, P. M., Barr, E. L. M., Khaw, K.-T., Psaty, B. M., Brenner, H., Balkau, B., Dekker, J. M., Lawlor, D. A., Daimon, M., ... Danesh, J. (2014). Glycated Hemoglobin Measurement and Prediction of Cardiovascular Disease. JAMA-Journal of the American Medical Association, 311(12), 1225-1233. https://doi.org/10.1001/jama.2014.1873

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title = "Glycated Hemoglobin Measurement and Prediction of Cardiovascular Disease",

abstract = "The value of measuring levels of glycated hemoglobin (HbA1c) for the prediction of first cardiovascular events is uncertain.To determine whether adding information on HbA1c values to conventional cardiovascular risk factors is associated with improvement in prediction of cardiovascular disease (CVD) risk.Analysis of individual-participant data available from 73 prospective studies involving 294,998 participants without a known history of diabetes mellitus or CVD at the baseline assessment.Measures of risk discrimination for CVD outcomes (eg, C-index) and reclassification (eg, net reclassification improvement) of participants across predicted 10-year risk categories of low (",

author = "{Di Angelantonio}, Emanuele and Pei Gao and Hassan Khan and Butterworth, {Adam S.} and David Wormser and Stephen Kaptoge and Seshasai, {Sreenivasa Rao Kondapally} and Alex Thompson and Nadeem Sarwar and Peter Willeit and Ridker, {Paul M.} and Barr, {Elizabeth L. M.} and Kay-Tee Khaw and Psaty, {Bruce M.} and Hermann Brenner and Beverley Balkau and Dekker, {Jacqueline M.} and Lawlor, {Debbie A.} and Makoto Daimon and Johann Willeit and Inger Njolstad and Aulikki Nissinen and Brunner, {Eric J.} and Kuller, {Lewis H.} and Price, {Jackie F.} and Johan Sundstrom and Knuiman, {Matthew W.} and Feskens, {Edith J. M.} and Verschuren, {W. M. M.} and Nicholas Wald and Bakker, {Stephan J. L.} and Whincup, {Peter H.} and Ian Ford and Uri Goldbourt and Agustin Gomez-de-la-Camara and John Gallacher and Simons, {Leon A.} and Annika Rosengren and Sutherland, {Susan E.} and Cecilia Bjorkelund and Blazer, {Dan G.} and Sylvia Wassertheil-Smoller and Altan Onat and Ibanez, {Alejandro Marin} and Edoardo Casiglia and Jukema, {J. Wouter} and Simpson, {Lara M.} and Simona Giampaoli and Nordestgaard, {Borge G.} and Randi Selmer and Patrik Wennberg and Jussi Kauhanen and Salonen, {Jukka T.} and Rachel Dankner and Elizabeth Barrett-Connor and Maryam Kavousi and Vilmundur Gudnason and Denis Evans and Wallace, {Robert B.} and Mary Cushman and D'Agostino, {Ralph B., Sr.} and Umans, {Jason G.} and Yutaka Kiyohara and Hidaeki Nakagawa and Shinichi Sato and Gillum, {Richard F.} and Folsom, {Aaron R.} and {van der Schouw}, {Yvonne T.} and Moons, {Karel G.} and Griffin, {Simon J.} and Naveed Sattar and Wareham, {Nicholas J.} and Elizabeth Selvin and Thompson, {Simon G.} and {Emerging Risk Factors Collaboration} and Coen Stehouwer and John Danesh",

year = "2014",

month = mar,

day = "26",

doi = "10.1001/jama.2014.1873",

language = "English",

volume = "311",

pages = "1225--1233",

journal = "JAMA-Journal of the American Medical Association",

issn = "0098-7484",

publisher = "American Medical Association",

number = "12",

}

Di Angelantonio, E, Gao, P, Khan, H, Butterworth, AS, Wormser, D, Kaptoge, S, Seshasai, SRK, Thompson, A, Sarwar, N, Willeit, P, Ridker, PM, Barr, ELM, Khaw, K-T, Psaty, BM, Brenner, H, Balkau, B, Dekker, JM, Lawlor, DA, Daimon, M, Willeit, J, Njolstad, I, Nissinen, A, Brunner, EJ, Kuller, LH, Price, JF, Sundstrom, J, Knuiman, MW, Feskens, EJM, Verschuren, WMM, Wald, N, Bakker, SJL, Whincup, PH, Ford, I, Goldbourt, U, Gomez-de-la-Camara, A, Gallacher, J, Simons, LA, Rosengren, A, Sutherland, SE, Bjorkelund, C, Blazer, DG, Wassertheil-Smoller, S, Onat, A, Ibanez, AM, Casiglia, E, Jukema, JW, Simpson, LM, Giampaoli, S, Nordestgaard, BG, Selmer, R, Wennberg, P, Kauhanen, J, Salonen, JT, Dankner, R, Barrett-Connor, E, Kavousi, M, Gudnason, V, Evans, D, Wallace, RB, Cushman, M, D'Agostino, RBS, Umans, JG, Kiyohara, Y, Nakagawa, H, Sato, S, Gillum, RF, Folsom, AR, van der Schouw, YT, Moons, KG, Griffin, SJ, Sattar, N, Wareham, NJ, Selvin, E, Thompson, SG, Emerging Risk Factors Collaboration, Stehouwer, C & Danesh, J 2014, 'Glycated Hemoglobin Measurement and Prediction of Cardiovascular Disease', JAMA-Journal of the American Medical Association, vol. 311, no. 12, pp. 1225-1233. https://doi.org/10.1001/jama.2014.1873

TY - JOUR

T1 - Glycated Hemoglobin Measurement and Prediction of Cardiovascular Disease

AU - Di Angelantonio, Emanuele

AU - Gao, Pei

AU - Khan, Hassan

AU - Butterworth, Adam S.

AU - Wormser, David

AU - Kaptoge, Stephen

AU - Seshasai, Sreenivasa Rao Kondapally

AU - Thompson, Alex

AU - Sarwar, Nadeem

AU - Willeit, Peter

AU - Ridker, Paul M.

AU - Barr, Elizabeth L. M.

AU - Khaw, Kay-Tee

AU - Psaty, Bruce M.

AU - Brenner, Hermann

AU - Balkau, Beverley

AU - Dekker, Jacqueline M.

AU - Lawlor, Debbie A.

AU - Daimon, Makoto

AU - Willeit, Johann

AU - Njolstad, Inger

AU - Nissinen, Aulikki

AU - Brunner, Eric J.

AU - Kuller, Lewis H.

AU - Price, Jackie F.

AU - Sundstrom, Johan

AU - Knuiman, Matthew W.

AU - Feskens, Edith J. M.

AU - Verschuren, W. M. M.

AU - Wald, Nicholas

AU - Bakker, Stephan J. L.

AU - Whincup, Peter H.

AU - Ford, Ian

AU - Goldbourt, Uri

AU - Gomez-de-la-Camara, Agustin

AU - Gallacher, John

AU - Simons, Leon A.

AU - Rosengren, Annika

AU - Sutherland, Susan E.

AU - Bjorkelund, Cecilia

AU - Blazer, Dan G.

AU - Wassertheil-Smoller, Sylvia

AU - Onat, Altan

AU - Ibanez, Alejandro Marin

AU - Casiglia, Edoardo

AU - Jukema, J. Wouter

AU - Simpson, Lara M.

AU - Giampaoli, Simona

AU - Nordestgaard, Borge G.

AU - Selmer, Randi

AU - Wennberg, Patrik

AU - Kauhanen, Jussi

AU - Salonen, Jukka T.

AU - Dankner, Rachel

AU - Barrett-Connor, Elizabeth

AU - Kavousi, Maryam

AU - Gudnason, Vilmundur

AU - Evans, Denis

AU - Wallace, Robert B.

AU - Cushman, Mary

AU - D'Agostino, Ralph B., Sr.

AU - Umans, Jason G.

AU - Kiyohara, Yutaka

AU - Nakagawa, Hidaeki

AU - Sato, Shinichi

AU - Gillum, Richard F.

AU - Folsom, Aaron R.

AU - van der Schouw, Yvonne T.

AU - Moons, Karel G.

AU - Griffin, Simon J.

AU - Sattar, Naveed

AU - Wareham, Nicholas J.

AU - Selvin, Elizabeth

AU - Thompson, Simon G.

AU - Emerging Risk Factors Collaboration,

AU - Stehouwer, Coen

AU - Danesh, John

PY - 2014/3/26

Y1 - 2014/3/26

N2 - The value of measuring levels of glycated hemoglobin (HbA1c) for the prediction of first cardiovascular events is uncertain.To determine whether adding information on HbA1c values to conventional cardiovascular risk factors is associated with improvement in prediction of cardiovascular disease (CVD) risk.Analysis of individual-participant data available from 73 prospective studies involving 294,998 participants without a known history of diabetes mellitus or CVD at the baseline assessment.Measures of risk discrimination for CVD outcomes (eg, C-index) and reclassification (eg, net reclassification improvement) of participants across predicted 10-year risk categories of low (

AB - The value of measuring levels of glycated hemoglobin (HbA1c) for the prediction of first cardiovascular events is uncertain.To determine whether adding information on HbA1c values to conventional cardiovascular risk factors is associated with improvement in prediction of cardiovascular disease (CVD) risk.Analysis of individual-participant data available from 73 prospective studies involving 294,998 participants without a known history of diabetes mellitus or CVD at the baseline assessment.Measures of risk discrimination for CVD outcomes (eg, C-index) and reclassification (eg, net reclassification improvement) of participants across predicted 10-year risk categories of low (

U2 - 10.1001/jama.2014.1873

DO - 10.1001/jama.2014.1873

M3 - Article

C2 - 24668104

SN - 0098-7484

VL - 311

SP - 1225

EP - 1233

JO - JAMA-Journal of the American Medical Association

JF - JAMA-Journal of the American Medical Association

IS - 12

ER -

Glycated Hemoglobin Measurement and Prediction of Cardiovascular Disease

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