TY - JOUR
T1 - Glycaemic Profiles of Children With Overweight and Obesity in Free-living Conditions in Association With Cardiometabolic Risk
AU - Rijks, Jesse
AU - Karnebeek, Kylie
AU - van Dijk, Jan-Willem
AU - Dorenbos, Elke
AU - Gerver, Wilhelmus
AU - Stouthart, Pauline
AU - Plat, Jogchum
AU - Vreugdenhil, Anita
PY - 2016/8/18
Y1 - 2016/8/18
N2 - Insulin resistance is common among children with overweight and obesity. However, knowledge about glucose fluctuations in these children is scarce. This study aims to evaluate glycaemic profiles in children with overweight and obesity in free-living conditions, and to examine the association between glycaemic profiles with insulin resistance and cardiovascular risk parameters. One hundred eleven children with overweight and obesity were included. 48-hour sensor glucose concentrations in free-living conditions, fasting plasma and post-glucose load concentrations, serum lipid and lipoprotein concentrations, homeostatic model assessment of insulin resistance (HOMA-IR), and blood pressure were evaluated. Hyperglycaemic glucose excursions (>= 7.8 mmol/L) were observed in 25% (n = 28) of the children. The median sensor glucose concentration was 5.0 (2.7-7.3) mmol/L, and correlated with fasting plasma glucose concentrations (r(s) = 0.190, p = 0.046), serum insulin concentrations (r(s) = 0.218, p = 0.021), and HOMA-IR (r(s) = 0.230, p = 0.015). The hyperglycaemic area under the curve (AUC) correlated with waist circumference z-score (r(s) = 0.455, p = 0.025), triacylglycerol concentrations (r(s) = 0.425, p = 0.024), and HOMA-IR (r(s) = 0.616, p <0.001). In conclusion, hyperglycaemic glucose excursions are frequently observed in children with overweight and obesity in free-living conditions. Children with insulin resistance had higher median sensor glucose concentrations and a larger hyperglycaemic sensor glucose AUC, which are both associated with specific parameters predicting cardiovascular disease risk.
AB - Insulin resistance is common among children with overweight and obesity. However, knowledge about glucose fluctuations in these children is scarce. This study aims to evaluate glycaemic profiles in children with overweight and obesity in free-living conditions, and to examine the association between glycaemic profiles with insulin resistance and cardiovascular risk parameters. One hundred eleven children with overweight and obesity were included. 48-hour sensor glucose concentrations in free-living conditions, fasting plasma and post-glucose load concentrations, serum lipid and lipoprotein concentrations, homeostatic model assessment of insulin resistance (HOMA-IR), and blood pressure were evaluated. Hyperglycaemic glucose excursions (>= 7.8 mmol/L) were observed in 25% (n = 28) of the children. The median sensor glucose concentration was 5.0 (2.7-7.3) mmol/L, and correlated with fasting plasma glucose concentrations (r(s) = 0.190, p = 0.046), serum insulin concentrations (r(s) = 0.218, p = 0.021), and HOMA-IR (r(s) = 0.230, p = 0.015). The hyperglycaemic area under the curve (AUC) correlated with waist circumference z-score (r(s) = 0.455, p = 0.025), triacylglycerol concentrations (r(s) = 0.425, p = 0.024), and HOMA-IR (r(s) = 0.616, p <0.001). In conclusion, hyperglycaemic glucose excursions are frequently observed in children with overweight and obesity in free-living conditions. Children with insulin resistance had higher median sensor glucose concentrations and a larger hyperglycaemic sensor glucose AUC, which are both associated with specific parameters predicting cardiovascular disease risk.
U2 - 10.1038/srep31892
DO - 10.1038/srep31892
M3 - Article
C2 - 27534260
SN - 2045-2322
VL - 6
JO - Scientific Reports
JF - Scientific Reports
M1 - 31892
ER -