Glomerular function in relation to circulating adhesion molecules and inflammation markers in a general population

Ying-Mei Feng*, Lutgarde Thijs, Zhen-Yu Zhang, Wen-Yi Yang, Qi-Fang Huang, Fang-Fei Wei, Tatiana Kuznetsova, Ann-Marie Jennings, Christian Delles, Rachael Lennox, Peter Verhamme, Anna Dominiczak, Jan A. Staessen*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    16 Citations (Web of Science)

    Abstract

    Inflammation is a hallmark of chronic kidney disease (CKD) and stimulates glomerular expression of vascular adhesion molecules (VCAMs). We investigated in a general population whether estimated glomerular filtration rate (eGFR) is associated with circulating adhesion molecules, inflammation markers or both. We measured serum levels of five adhesion molecules [VCAM-1, intracellular adhesion molecule-1 (ICAM-1), P-selectin, E-selectin and monocyte chemoattractant protein-1 (MCP-1)] and seven inflammation markers [C-reactive protein (CRP), neutrophil gelatinase-associated lipocalin (NGAL), tumour necrosis factor receptor 1 (TNF-R1), TNF-alpha, interleukin 6 (IL-6), IL-8 and vascular endothelial growth factor] in 1338 randomly recruited people (50.8% women, mean age 51.7 years, eGFR 79.9 mL/min/1.73 m(2)). In multivariable-adjusted analyses, eGFR decreased (P <= 0.004) with higher VCAM-1 (association size expressed in mL/min/1.73 m(2) for a doubling of the marker, -2.99), MCP-1 (-1.19), NGAL (-1.19), TNF receptor 1 (-2.78), TNF-alpha (-2.28) and IL-6 (-0.94). The odds ratios of having eGFR < 60 versus >= 60 mL/min/1.73 m(2) (n = 138 versus 1200) were significant (P <= 0.001) for VCAM-1 (1.77), MCP-1 (1.32), NGAL (1.26), TNF-R1 (1.49), TNF-alpha (1.45) and IL-6 (1.20). Compared with 24-h albuminuria, VCAM-1 increased (P < 0.0001) the area under the curve from 0.57 to 0.65, MCP-1 to 0.67 and TNF-R1 to 0.79, but TNF-R1 outperformed both adhesion molecules (P < 0.0001). In a general population, eGFR is inversely associated with circulating adhesion molecules VCAM-1 and MCP-1 and several inflammation markers, but inflammation markers, in particular TNF-R1 and TNF-alpha, identify patients with eGFR < 60 mL/min/1.73 m(2) more accurately.
    Original languageEnglish
    Pages (from-to)426-435
    Number of pages10
    JournalNephrology Dialysis Transplantation
    Volume33
    Issue number3
    DOIs
    Publication statusPublished - 1 Mar 2018

    Keywords

    • adhesion molecules
    • eGFR
    • inflammation
    • population science
    • renal function
    • CHRONIC KIDNEY-DISEASE
    • EJECTION FRACTION
    • ENDOTHELIAL-CELLS
    • URINARY PROTEOME
    • FILTRATION-RATE
    • HEART-FAILURE
    • BIOMARKERS
    • EXPRESSION
    • ATHEROSCLEROSIS
    • COAGULATION

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