Global Proteomic and Methylome Analysis in Human Induced Pluripotent Stem Cells Reveals Overexpression of a Human TLR3 Affecting Proper Innate Immune Response Signaling

Jordi Requena; Ana Belen Alvarez-Palomo; Montserrat Codina-Pascual; Raul Delgado-Morales; Sebastian Moran; Manel Esteller; Marti Sal; Manel Juan; Anna Boronat Barado; Antonella Consiglio; Orleigh Addeleccia Bogle; Ernst Wolvetang; Dmitry Ovchinnikov; Inaki Alvarez; Dolores Jaraquemada; Jovita Mezquita-Pla; Rafael Oliva; Michael J. Edel

doi:10.1002/stem.2966

Global Proteomic and Methylome Analysis in Human Induced Pluripotent Stem Cells Reveals Overexpression of a Human TLR3 Affecting Proper Innate Immune Response Signaling

Jordi Requena, Ana Belen Alvarez-Palomo, Montserrat Codina-Pascual, Raul Delgado-Morales, Sebastian Moran, Manel Esteller, Marti Sal, Manel Juan, Anna Boronat Barado, Antonella Consiglio, Orleigh Addeleccia Bogle, Ernst Wolvetang, Dmitry Ovchinnikov, Inaki Alvarez, Dolores Jaraquemada, Jovita Mezquita-Pla, Rafael Oliva, Michael J. Edel^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	476-488
Number of pages	13
Journal	Stem Cells
Volume	37
Issue number	4
DOIs	https://doi.org/10.1002/stem.2966
Publication status	Published - Apr 2019

Keywords

Cytokine
Human leukocyte antigen
Immune response
Induced pluripotent stem cells
Inflammation
MHC-I
Neural stem cells
Toll like receptor
IMMUNOGENICITY
BIOINFORMATICS
EXPRESSION
ACTIVATION
NEURONS
ROLES

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10.1002/stem.2966

Cite this

Requena, J., Belen Alvarez-Palomo, A., Codina-Pascual, M., Delgado-Morales, R., Moran, S., Esteller, M., Sal, M., Juan, M., Boronat Barado, A., Consiglio, A., Addeleccia Bogle, O., Wolvetang, E., Ovchinnikov, D., Alvarez, I., Jaraquemada, D., Mezquita-Pla, J., Oliva, R., & Edel, M. J. (2019). Global Proteomic and Methylome Analysis in Human Induced Pluripotent Stem Cells Reveals Overexpression of a Human TLR3 Affecting Proper Innate Immune Response Signaling. Stem Cells, 37(4), 476-488. https://doi.org/10.1002/stem.2966

Requena, Jordi ; Belen Alvarez-Palomo, Ana ; Codina-Pascual, Montserrat ; Delgado-Morales, Raul ; Moran, Sebastian ; Esteller, Manel ; Sal, Marti ; Juan, Manel ; Boronat Barado, Anna ; Consiglio, Antonella ; Addeleccia Bogle, Orleigh ; Wolvetang, Ernst ; Ovchinnikov, Dmitry ; Alvarez, Inaki ; Jaraquemada, Dolores ; Mezquita-Pla, Jovita ; Oliva, Rafael ; Edel, Michael J. / Global Proteomic and Methylome Analysis in Human Induced Pluripotent Stem Cells Reveals Overexpression of a Human TLR3 Affecting Proper Innate Immune Response Signaling. In: Stem Cells. 2019 ; Vol. 37, No. 4. pp. 476-488.

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title = "Global Proteomic and Methylome Analysis in Human Induced Pluripotent Stem Cells Reveals Overexpression of a Human TLR3 Affecting Proper Innate Immune Response Signaling",

keywords = "Cytokine, Human leukocyte antigen, Immune response, Induced pluripotent stem cells, Inflammation, MHC-I, Neural stem cells, Toll like receptor, IMMUNOGENICITY, BIOINFORMATICS, EXPRESSION, ACTIVATION, NEURONS, ROLES",

author = "Jordi Requena and {Belen Alvarez-Palomo}, Ana and Montserrat Codina-Pascual and Raul Delgado-Morales and Sebastian Moran and Manel Esteller and Marti Sal and Manel Juan and {Boronat Barado}, Anna and Antonella Consiglio and {Addeleccia Bogle}, Orleigh and Ernst Wolvetang and Dmitry Ovchinnikov and Inaki Alvarez and Dolores Jaraquemada and Jovita Mezquita-Pla and Rafael Oliva and Edel, {Michael J.}",

year = "2019",

month = apr,

doi = "10.1002/stem.2966",

language = "English",

volume = "37",

pages = "476--488",

journal = "Stem Cells",

issn = "1066-5099",

publisher = "Wiley",

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Requena, J, Belen Alvarez-Palomo, A, Codina-Pascual, M, Delgado-Morales, R, Moran, S, Esteller, M, Sal, M, Juan, M, Boronat Barado, A, Consiglio, A, Addeleccia Bogle, O, Wolvetang, E, Ovchinnikov, D, Alvarez, I, Jaraquemada, D, Mezquita-Pla, J, Oliva, R & Edel, MJ 2019, 'Global Proteomic and Methylome Analysis in Human Induced Pluripotent Stem Cells Reveals Overexpression of a Human TLR3 Affecting Proper Innate Immune Response Signaling', Stem Cells, vol. 37, no. 4, pp. 476-488. https://doi.org/10.1002/stem.2966

Global Proteomic and Methylome Analysis in Human Induced Pluripotent Stem Cells Reveals Overexpression of a Human TLR3 Affecting Proper Innate Immune Response Signaling. / Requena, Jordi; Belen Alvarez-Palomo, Ana; Codina-Pascual, Montserrat; Delgado-Morales, Raul; Moran, Sebastian; Esteller, Manel; Sal, Marti; Juan, Manel; Boronat Barado, Anna; Consiglio, Antonella; Addeleccia Bogle, Orleigh; Wolvetang, Ernst; Ovchinnikov, Dmitry; Alvarez, Inaki; Jaraquemada, Dolores; Mezquita-Pla, Jovita; Oliva, Rafael; Edel, Michael J.

In: Stem Cells, Vol. 37, No. 4, 04.2019, p. 476-488.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - Requena, Jordi

AU - Belen Alvarez-Palomo, Ana

AU - Codina-Pascual, Montserrat

AU - Delgado-Morales, Raul

AU - Moran, Sebastian

AU - Esteller, Manel

AU - Sal, Marti

AU - Juan, Manel

AU - Boronat Barado, Anna

AU - Consiglio, Antonella

AU - Addeleccia Bogle, Orleigh

AU - Wolvetang, Ernst

AU - Ovchinnikov, Dmitry

AU - Alvarez, Inaki

AU - Jaraquemada, Dolores

AU - Mezquita-Pla, Jovita

AU - Oliva, Rafael

AU - Edel, Michael J.

PY - 2019/4

Y1 - 2019/4

KW - Cytokine

KW - Human leukocyte antigen

KW - Immune response

KW - Induced pluripotent stem cells

KW - Inflammation

KW - MHC-I

KW - Neural stem cells

KW - Toll like receptor

KW - IMMUNOGENICITY

KW - BIOINFORMATICS

KW - EXPRESSION

KW - ACTIVATION

KW - NEURONS

KW - ROLES

U2 - 10.1002/stem.2966

DO - 10.1002/stem.2966

M3 - Article

C2 - 30664289

VL - 37

SP - 476

EP - 488

JO - Stem Cells

JF - Stem Cells

SN - 1066-5099

IS - 4

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