Germline AGO2 mutations impair RNA interference and human neurological development

D. Lessel, D.M. Zeitler, M.R.F. Reijnders, A. Kazantsev, F.H. Nia, A. Bartholomaus, V. Martens, A. Bruckmann, V. Graus, A. McConkie-Rosell, M. McDonald, B. Lozic, E.S. Tan, E. Gerkes, J. Johannsen, J. Denecke, A. Telegrafi, E. Zonneveld-Huijssoon, H.H. Lemmink, B.W.M. ChamT. Kovacevic, L. Ramsdell, K. Foss, D. Le Duc, D. Mitter, S. Syrbe, A. Merkenschlager, M. Sinnema, B. Panis, J. Lazier, M. Osmond, T. Hartley, J. Mortreux, T. Busa, C. Missirian, P. Prasun, S. Luttgen, I. Mannucci, I. Lessel, C. Schob, S. Kindler, J. Pappas, R. Rabin, M. Willemsen, T. Gardeitchik, K. Lohner, P. Rump, K.R. Dias, C.A. Evans, P.I. Andrews

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Web of Science)
Original languageEnglish
Article number5797
Number of pages14
JournalNature Communications
Volume11
Issue number1
DOIs
Publication statusPublished - 16 Nov 2020

Keywords

  • argonaute proteins
  • cleavage
  • crystal-structure
  • gene
  • intellectual disability
  • micrornas
  • molecular-dynamics
  • phosphorylation
  • recognition
  • structural basis
  • MOLECULAR-DYNAMICS
  • RECOGNITION
  • PHOSPHORYLATION
  • CRYSTAL-STRUCTURE
  • MICRORNAS
  • CLEAVAGE
  • INTELLECTUAL DISABILITY
  • GENE
  • STRUCTURAL BASIS
  • ARGONAUTE PROTEINS

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