GEP-NET radiomics: a systematic review and radiomics quality score assessment

F.C.R. Staal, E.A. Aalbersberg, D. van der Velden, E.A. Wilthagen, M.E.T. Tesselaar, R.G.H. Beets-Tan, M. Maas*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

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Abstract

Objective The number of radiomics studies in gastroenteropancreatic neuroendocrine tumours (GEP-NETs) is rapidly increasing. This systematic review aims to provide an overview of the available evidence of radiomics for clinical outcome measures in GEP-NETs, to understand which applications hold the most promise and which areas lack evidence. Methods PubMed, Embase, and Wiley/Cochrane Library databases were searched and a forward and backward reference check of the identified studies was executed. Inclusion criteria were (1) patients with GEP-NETs and (2) radiomics analysis on CT, MRI or PET. Two reviewers independently agreed on eligibility and assessed methodological quality with the radiomics quality score (RQS) and extracted outcome data. Results In total, 1364 unique studies were identified and 45 were included for analysis. Most studies focused on GEP-NET grade and differential diagnosis of GEP-NETs from other neoplasms, while only a minority analysed treatment response or long-term outcomes. Several studies were able to predict tumour grade or to differentiate GEP-NETs from other lesions with a good performance (AUCs 0.74-0.96 and AUCs 0.80-0.99, respectively). Only one study developed a model to predict recurrence in pancreas NETs (AUC 0.77). The included studies reached a mean RQS of 18%. Conclusion Although radiomics for GEP-NETs is still a relatively new area, some promising models have been developed. Future research should focus on developing robust models for clinically relevant aims such as prediction of response or long-term outcome in GEP-NET, since evidence for these aims is still scarce.
Original languageEnglish
Pages (from-to)7278-7294
Number of pages17
JournalEuropean Radiology
Volume32
Issue number10
Early online date26 Jul 2022
DOIs
Publication statusPublished - Oct 2022

Keywords

  • Neuroendocrine tumors
  • Gastrointestinal neoplasms
  • Artificial intelligence
  • Machine learning
  • PANCREATIC NEUROENDOCRINE TUMOR
  • TEXTURE ANALYSIS
  • HISTOGRAM ANALYSIS
  • GRADE
  • HETEROGENEITY
  • PREDICTION
  • PARAMETERS
  • NEOPLASMS
  • IMAGES

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