Genomic and epigenomic EBF1 alterations modulate TERT expression in gastric cancer

Manjie Xing; Wen Fong Ooi; Jing Tan; Aditi Qamra; Po-Hsien Lee; Zhimei Li; Chang Xu; Nisha Padmanabhan; Jing Quan Lim; Yu Amanda Guo; Xiaosai Yao; Mandoli Amit; Ley Moy Ng; Taotao Sheng; Jing Wang; Kie Kyon Huang; Chukwuemeka George Anene-Nzelu; Shamaine Wei Ting Ho; Mohana Ray; Lijia Ma; Gregorio Fazzi; Kevin Junliang Lim; Giovani Claresta Wijaya; Shenli Zhang; Tannistha Nandi; Tingdong Yan; Mei Mei Chang; Kakoli Das; Zul Fazreen Adam Isa; Jeanie Wu; Polly Suk Yean Poon; Yue Ning Lam; Joyce Suling Lin; Su Ting Tay; Ming Hui Lee; Angie Lay Keng Tan; Xuewen Ong; Kevin White; Steven George Rozen; Michael Beer; Roger Sik Yin Foo; Heike Irmgard Grabsch; Anders Jacobsen Skanderup; Shang Li; Bin Tean Teh; Patrick Tan

doi:10.1172/JCI126726

Genomic and epigenomic EBF1 alterations modulate TERT expression in gastric cancer

Manjie Xing, Wen Fong Ooi, Jing Tan, Aditi Qamra, Po-Hsien Lee, Zhimei Li, Chang Xu, Nisha Padmanabhan, Jing Quan Lim, Yu Amanda Guo, Xiaosai Yao, Mandoli Amit, Ley Moy Ng, Taotao Sheng, Jing Wang, Kie Kyon Huang, Chukwuemeka George Anene-Nzelu, Shamaine Wei Ting Ho, Mohana Ray, Lijia MaGregorio Fazzi, Kevin Junliang Lim, Giovani Claresta Wijaya, Shenli Zhang, Tannistha Nandi, Tingdong Yan, Mei Mei Chang, Kakoli Das, Zul Fazreen Adam Isa, Jeanie Wu, Polly Suk Yean Poon, Yue Ning Lam, Joyce Suling Lin, Su Ting Tay, Ming Hui Lee, Angie Lay Keng Tan, Xuewen Ong, Kevin White, Steven George Rozen, Michael Beer, Roger Sik Yin Foo, Heike Irmgard Grabsch, Anders Jacobsen Skanderup, Shang Li, Bin Tean Teh, Patrick Tan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	3005-3020
Number of pages	16
Journal	Journal of Clinical Investigation
Volume	130
Issue number	6
DOIs	https://doi.org/10.1172/JCI126726
Publication status	Published - 1 Jun 2020

Keywords

B-CELL FACTOR-1
GROUP PROTEIN EZH2
PROMOTER MUTATIONS
TRANSCRIPTION FACTORS
TELOMERASE ACTIVITY
DIFFERENTIATION
CAPECITABINE
CHEMOTHERAPY
PROGRESSION
RECOGNITION

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10.1172/JCI126726

Cite this

Xing, M., Ooi, W. F., Tan, J., Qamra, A., Lee, P-H., Li, Z., Xu, C., Padmanabhan, N., Lim, J. Q., Guo, Y. A., Yao, X., Amit, M., Ng, L. M., Sheng, T., Wang, J., Huang, K. K., Anene-Nzelu, C. G., Ho, S. W. T., Ray, M., ... Tan, P. (2020). Genomic and epigenomic EBF1 alterations modulate TERT expression in gastric cancer. Journal of Clinical Investigation, 130(6), 3005-3020. https://doi.org/10.1172/JCI126726

Xing, Manjie ; Ooi, Wen Fong ; Tan, Jing ; Qamra, Aditi ; Lee, Po-Hsien ; Li, Zhimei ; Xu, Chang ; Padmanabhan, Nisha ; Lim, Jing Quan ; Guo, Yu Amanda ; Yao, Xiaosai ; Amit, Mandoli ; Ng, Ley Moy ; Sheng, Taotao ; Wang, Jing ; Huang, Kie Kyon ; Anene-Nzelu, Chukwuemeka George ; Ho, Shamaine Wei Ting ; Ray, Mohana ; Ma, Lijia ; Fazzi, Gregorio ; Lim, Kevin Junliang ; Wijaya, Giovani Claresta ; Zhang, Shenli ; Nandi, Tannistha ; Yan, Tingdong ; Chang, Mei Mei ; Das, Kakoli ; Isa, Zul Fazreen Adam ; Wu, Jeanie ; Poon, Polly Suk Yean ; Lam, Yue Ning ; Lin, Joyce Suling ; Tay, Su Ting ; Lee, Ming Hui ; Tan, Angie Lay Keng ; Ong, Xuewen ; White, Kevin ; Rozen, Steven George ; Beer, Michael ; Foo, Roger Sik Yin ; Grabsch, Heike Irmgard ; Skanderup, Anders Jacobsen ; Li, Shang ; Teh, Bin Tean ; Tan, Patrick. / Genomic and epigenomic EBF1 alterations modulate TERT expression in gastric cancer. In: Journal of Clinical Investigation. 2020 ; Vol. 130, No. 6. pp. 3005-3020.

@article{a4b154ceff3f4beb9548cfcbcab7cf3e,

title = "Genomic and epigenomic EBF1 alterations modulate TERT expression in gastric cancer",

keywords = "B-CELL FACTOR-1, GROUP PROTEIN EZH2, PROMOTER MUTATIONS, TRANSCRIPTION FACTORS, TELOMERASE ACTIVITY, DIFFERENTIATION, CAPECITABINE, CHEMOTHERAPY, PROGRESSION, RECOGNITION",

author = "Manjie Xing and Ooi, {Wen Fong} and Jing Tan and Aditi Qamra and Po-Hsien Lee and Zhimei Li and Chang Xu and Nisha Padmanabhan and Lim, {Jing Quan} and Guo, {Yu Amanda} and Xiaosai Yao and Mandoli Amit and Ng, {Ley Moy} and Taotao Sheng and Jing Wang and Huang, {Kie Kyon} and Anene-Nzelu, {Chukwuemeka George} and Ho, {Shamaine Wei Ting} and Mohana Ray and Lijia Ma and Gregorio Fazzi and Lim, {Kevin Junliang} and Wijaya, {Giovani Claresta} and Shenli Zhang and Tannistha Nandi and Tingdong Yan and Chang, {Mei Mei} and Kakoli Das and Isa, {Zul Fazreen Adam} and Jeanie Wu and Poon, {Polly Suk Yean} and Lam, {Yue Ning} and Lin, {Joyce Suling} and Tay, {Su Ting} and Lee, {Ming Hui} and Tan, {Angie Lay Keng} and Xuewen Ong and Kevin White and Rozen, {Steven George} and Michael Beer and Foo, {Roger Sik Yin} and Grabsch, {Heike Irmgard} and Skanderup, {Anders Jacobsen} and Shang Li and Teh, {Bin Tean} and Patrick Tan",

year = "2020",

month = jun,

day = "1",

doi = "10.1172/JCI126726",

language = "English",

volume = "130",

pages = "3005--3020",

journal = "Journal of Clinical Investigation",

issn = "0021-9738",

publisher = "American Society for Clinical Investigation",

number = "6",

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Xing, M, Ooi, WF, Tan, J, Qamra, A, Lee, P-H, Li, Z, Xu, C, Padmanabhan, N, Lim, JQ, Guo, YA, Yao, X, Amit, M, Ng, LM, Sheng, T, Wang, J, Huang, KK, Anene-Nzelu, CG, Ho, SWT, Ray, M, Ma, L, Fazzi, G, Lim, KJ, Wijaya, GC, Zhang, S, Nandi, T, Yan, T, Chang, MM, Das, K, Isa, ZFA, Wu, J, Poon, PSY, Lam, YN, Lin, JS, Tay, ST, Lee, MH, Tan, ALK, Ong, X, White, K, Rozen, SG, Beer, M, Foo, RSY, Grabsch, HI, Skanderup, AJ, Li, S, Teh, BT & Tan, P 2020, 'Genomic and epigenomic EBF1 alterations modulate TERT expression in gastric cancer', Journal of Clinical Investigation, vol. 130, no. 6, pp. 3005-3020. https://doi.org/10.1172/JCI126726

Genomic and epigenomic EBF1 alterations modulate TERT expression in gastric cancer. / Xing, Manjie; Ooi, Wen Fong; Tan, Jing; Qamra, Aditi; Lee, Po-Hsien; Li, Zhimei; Xu, Chang; Padmanabhan, Nisha; Lim, Jing Quan; Guo, Yu Amanda; Yao, Xiaosai; Amit, Mandoli; Ng, Ley Moy; Sheng, Taotao; Wang, Jing; Huang, Kie Kyon; Anene-Nzelu, Chukwuemeka George; Ho, Shamaine Wei Ting; Ray, Mohana; Ma, Lijia; Fazzi, Gregorio; Lim, Kevin Junliang; Wijaya, Giovani Claresta; Zhang, Shenli; Nandi, Tannistha; Yan, Tingdong; Chang, Mei Mei; Das, Kakoli; Isa, Zul Fazreen Adam; Wu, Jeanie; Poon, Polly Suk Yean; Lam, Yue Ning; Lin, Joyce Suling; Tay, Su Ting; Lee, Ming Hui; Tan, Angie Lay Keng; Ong, Xuewen; White, Kevin; Rozen, Steven George; Beer, Michael; Foo, Roger Sik Yin; Grabsch, Heike Irmgard; Skanderup, Anders Jacobsen; Li, Shang; Teh, Bin Tean; Tan, Patrick.

In: Journal of Clinical Investigation, Vol. 130, No. 6, 01.06.2020, p. 3005-3020.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Genomic and epigenomic EBF1 alterations modulate TERT expression in gastric cancer

AU - Xing, Manjie

AU - Ooi, Wen Fong

AU - Tan, Jing

AU - Qamra, Aditi

AU - Lee, Po-Hsien

AU - Li, Zhimei

AU - Xu, Chang

AU - Padmanabhan, Nisha

AU - Lim, Jing Quan

AU - Guo, Yu Amanda

AU - Yao, Xiaosai

AU - Amit, Mandoli

AU - Ng, Ley Moy

AU - Sheng, Taotao

AU - Wang, Jing

AU - Huang, Kie Kyon

AU - Anene-Nzelu, Chukwuemeka George

AU - Ho, Shamaine Wei Ting

AU - Ray, Mohana

AU - Ma, Lijia

AU - Fazzi, Gregorio

AU - Lim, Kevin Junliang

AU - Wijaya, Giovani Claresta

AU - Zhang, Shenli

AU - Nandi, Tannistha

AU - Yan, Tingdong

AU - Chang, Mei Mei

AU - Das, Kakoli

AU - Isa, Zul Fazreen Adam

AU - Wu, Jeanie

AU - Poon, Polly Suk Yean

AU - Lam, Yue Ning

AU - Lin, Joyce Suling

AU - Tay, Su Ting

AU - Lee, Ming Hui

AU - Tan, Angie Lay Keng

AU - Ong, Xuewen

AU - White, Kevin

AU - Rozen, Steven George

AU - Beer, Michael

AU - Foo, Roger Sik Yin

AU - Grabsch, Heike Irmgard

AU - Skanderup, Anders Jacobsen

AU - Li, Shang

AU - Teh, Bin Tean

AU - Tan, Patrick

PY - 2020/6/1

Y1 - 2020/6/1

KW - B-CELL FACTOR-1

KW - GROUP PROTEIN EZH2

KW - PROMOTER MUTATIONS

KW - TRANSCRIPTION FACTORS

KW - TELOMERASE ACTIVITY

KW - DIFFERENTIATION

KW - CAPECITABINE

KW - CHEMOTHERAPY

KW - PROGRESSION

KW - RECOGNITION

U2 - 10.1172/JCI126726

DO - 10.1172/JCI126726

M3 - Article

C2 - 32364535

VL - 130

SP - 3005

EP - 3020

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

SN - 0021-9738

IS - 6

ER -