Genome-Wide Association Study to Identify Common Variants Associated with Brachial Circumference: A Meta-Analysis of 14 Cohorts

Vesna Boraska; Aaron Day-Williams; Christopher S. Franklin; Katherine S. Elliott; Kalliope Panoutsopoulou; Ioanna Tachmazidou; Eva Albrecht; Stefania Bandinelli; Lawrence J. Beilin; Murielle Bochud; Gemma Cadby; Florian Ernst; David M. Evans; Caroline Hayward; Andrew A. Hicks; Jennifer Huffman; Cornelia Huth; Alan L. James; Norman Klopp; Ivana Kolcic; Zoltan Kutalik; Debbie A. Lawlor; Arthur W. Musk; Marina Pehlic; Craig E. Pennell; John R. B. Perry; Annette Peters; Ozren Polasek; Beate St Pourcain; Susan M. Ring; Erika Salvi; Sabine Schipf; Jan A. Staessen; Alexander Teumer; Nicholas Timpson; Veronique Vitart; Nicole M. Warrington; Hanieh Yaghootkar; Tatijana Zemunik; Lina Zgaga; Ping An; Verneri Anttila; Ingrid B. Borecki; Jostein Holmen; Ioanna Ntalla; Aarno Palotie; Kirsi H. Pietilainen; Juho Wedenoja; Bendik S. Winsvold; George V. Dedoussis; Jaakko Kaprio; Michael A. Province; John-Anker Zwart; Michel Burnier; Harry Campbell; Daniele Cusi; George Davey Smith; Timothy M. Frayling; Christian Gieger; Lyle J. Palmer; Peter P. Pramstaller; Igor Rudan; Henry Voelzke; H. Erich Wichmann; Alan F. Wright; Eleftheria Zeggini

doi:10.1371/journal.pone.0031369

Genome-Wide Association Study to Identify Common Variants Associated with Brachial Circumference: A Meta-Analysis of 14 Cohorts

Vesna Boraska^*, Aaron Day-Williams, Christopher S. Franklin, Katherine S. Elliott, Kalliope Panoutsopoulou, Ioanna Tachmazidou, Eva Albrecht, Stefania Bandinelli, Lawrence J. Beilin, Murielle Bochud, Gemma Cadby, Florian Ernst, David M. Evans, Caroline Hayward, Andrew A. Hicks, Jennifer Huffman, Cornelia Huth, Alan L. James, Norman Klopp, Ivana KolcicZoltan Kutalik, Debbie A. Lawlor, Arthur W. Musk, Marina Pehlic, Craig E. Pennell, John R. B. Perry, Annette Peters, Ozren Polasek, Beate St Pourcain, Susan M. Ring, Erika Salvi, Sabine Schipf, Jan A. Staessen, Alexander Teumer, Nicholas Timpson, Veronique Vitart, Nicole M. Warrington, Hanieh Yaghootkar, Tatijana Zemunik, Lina Zgaga, Ping An, Verneri Anttila, Ingrid B. Borecki, Jostein Holmen, Ioanna Ntalla, Aarno Palotie, Kirsi H. Pietilainen, Juho Wedenoja, Bendik S. Winsvold, George V. Dedoussis, Jaakko Kaprio, Michael A. Province, John-Anker Zwart, Michel Burnier, Harry Campbell, Daniele Cusi, George Davey Smith, Timothy M. Frayling, Christian Gieger, Lyle J. Palmer, Peter P. Pramstaller, Igor Rudan, Henry Voelzke, H. Erich Wichmann, Alan F. Wright, Eleftheria Zeggini

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Brachial circumference (BC), also known as upper arm or mid arm circumference, can be used as an indicator of muscle mass and fat tissue, which are distributed differently in men and women. Analysis of anthropometric measures of peripheral fat distribution such as BC could help in understanding the complex pathophysiology behind overweight and obesity. The purpose of this study is to identify genetic variants associated with BC through a large-scale genome-wide association scan (GWAS) meta-analysis. We used fixed-effects meta-analysis to synthesise summary results across 14 GWAS discovery and 4 replication cohorts comprising overall 22,376 individuals (12,031 women and 10,345 men) of European ancestry. Individual analyses were carried out for men, women, and combined across sexes using linear regression and an additive genetic model: adjusted for age and adjusted for age and BMI. We prioritised signals for follow-up in two-stages. We did not detect any signals reaching genome-wide significance. The FTO rs9939609 SNP showed nominal evidence for association (p

Original language	English
Article number	e31369
Journal	PLOS ONE
Volume	7
Issue number	3
DOIs	https://doi.org/10.1371/journal.pone.0031369
Publication status	Published - 29 Mar 2012

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10.1371/journal.pone.0031369Licence: CC BY

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Boraska, V., Day-Williams, A., Franklin, C. S., Elliott, K. S., Panoutsopoulou, K., Tachmazidou, I., Albrecht, E., Bandinelli, S., Beilin, L. J., Bochud, M., Cadby, G., Ernst, F., Evans, D. M., Hayward, C., Hicks, A. A., Huffman, J., Huth, C., James, A. L., Klopp, N., ... Zeggini, E. (2012). Genome-Wide Association Study to Identify Common Variants Associated with Brachial Circumference: A Meta-Analysis of 14 Cohorts. PLOS ONE, 7(3), Article e31369. https://doi.org/10.1371/journal.pone.0031369

@article{dba278adeff54541aab511b584155102,

title = "Genome-Wide Association Study to Identify Common Variants Associated with Brachial Circumference: A Meta-Analysis of 14 Cohorts",

abstract = "Brachial circumference (BC), also known as upper arm or mid arm circumference, can be used as an indicator of muscle mass and fat tissue, which are distributed differently in men and women. Analysis of anthropometric measures of peripheral fat distribution such as BC could help in understanding the complex pathophysiology behind overweight and obesity. The purpose of this study is to identify genetic variants associated with BC through a large-scale genome-wide association scan (GWAS) meta-analysis. We used fixed-effects meta-analysis to synthesise summary results across 14 GWAS discovery and 4 replication cohorts comprising overall 22,376 individuals (12,031 women and 10,345 men) of European ancestry. Individual analyses were carried out for men, women, and combined across sexes using linear regression and an additive genetic model: adjusted for age and adjusted for age and BMI. We prioritised signals for follow-up in two-stages. We did not detect any signals reaching genome-wide significance. The FTO rs9939609 SNP showed nominal evidence for association (p",

author = "Vesna Boraska and Aaron Day-Williams and Franklin, {Christopher S.} and Elliott, {Katherine S.} and Kalliope Panoutsopoulou and Ioanna Tachmazidou and Eva Albrecht and Stefania Bandinelli and Beilin, {Lawrence J.} and Murielle Bochud and Gemma Cadby and Florian Ernst and Evans, {David M.} and Caroline Hayward and Hicks, {Andrew A.} and Jennifer Huffman and Cornelia Huth and James, {Alan L.} and Norman Klopp and Ivana Kolcic and Zoltan Kutalik and Lawlor, {Debbie A.} and Musk, {Arthur W.} and Marina Pehlic and Pennell, {Craig E.} and Perry, {John R. B.} and Annette Peters and Ozren Polasek and {St Pourcain}, Beate and Ring, {Susan M.} and Erika Salvi and Sabine Schipf and Staessen, {Jan A.} and Alexander Teumer and Nicholas Timpson and Veronique Vitart and Warrington, {Nicole M.} and Hanieh Yaghootkar and Tatijana Zemunik and Lina Zgaga and Ping An and Verneri Anttila and Borecki, {Ingrid B.} and Jostein Holmen and Ioanna Ntalla and Aarno Palotie and Pietilainen, {Kirsi H.} and Juho Wedenoja and Winsvold, {Bendik S.} and Dedoussis, {George V.} and Jaakko Kaprio and Province, {Michael A.} and John-Anker Zwart and Michel Burnier and Harry Campbell and Daniele Cusi and Smith, {George Davey} and Frayling, {Timothy M.} and Christian Gieger and Palmer, {Lyle J.} and Pramstaller, {Peter P.} and Igor Rudan and Henry Voelzke and Wichmann, {H. Erich} and Wright, {Alan F.} and Eleftheria Zeggini",

year = "2012",

month = mar,

day = "29",

doi = "10.1371/journal.pone.0031369",

language = "English",

volume = "7",

journal = "PLOS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "3",

}

Boraska, V, Day-Williams, A, Franklin, CS, Elliott, KS, Panoutsopoulou, K, Tachmazidou, I, Albrecht, E, Bandinelli, S, Beilin, LJ, Bochud, M, Cadby, G, Ernst, F, Evans, DM, Hayward, C, Hicks, AA, Huffman, J, Huth, C, James, AL, Klopp, N, Kolcic, I, Kutalik, Z, Lawlor, DA, Musk, AW, Pehlic, M, Pennell, CE, Perry, JRB, Peters, A, Polasek, O, St Pourcain, B, Ring, SM, Salvi, E, Schipf, S, Staessen, JA, Teumer, A, Timpson, N, Vitart, V, Warrington, NM, Yaghootkar, H, Zemunik, T, Zgaga, L, An, P, Anttila, V, Borecki, IB, Holmen, J, Ntalla, I, Palotie, A, Pietilainen, KH, Wedenoja, J, Winsvold, BS, Dedoussis, GV, Kaprio, J, Province, MA, Zwart, J-A, Burnier, M, Campbell, H, Cusi, D, Smith, GD, Frayling, TM, Gieger, C, Palmer, LJ, Pramstaller, PP, Rudan, I, Voelzke, H, Wichmann, HE, Wright, AF & Zeggini, E 2012, 'Genome-Wide Association Study to Identify Common Variants Associated with Brachial Circumference: A Meta-Analysis of 14 Cohorts', PLOS ONE, vol. 7, no. 3, e31369. https://doi.org/10.1371/journal.pone.0031369

TY - JOUR

T1 - Genome-Wide Association Study to Identify Common Variants Associated with Brachial Circumference: A Meta-Analysis of 14 Cohorts

AU - Boraska, Vesna

AU - Day-Williams, Aaron

AU - Franklin, Christopher S.

AU - Elliott, Katherine S.

AU - Panoutsopoulou, Kalliope

AU - Tachmazidou, Ioanna

AU - Albrecht, Eva

AU - Bandinelli, Stefania

AU - Beilin, Lawrence J.

AU - Bochud, Murielle

AU - Cadby, Gemma

AU - Ernst, Florian

AU - Evans, David M.

AU - Hayward, Caroline

AU - Hicks, Andrew A.

AU - Huffman, Jennifer

AU - Huth, Cornelia

AU - James, Alan L.

AU - Klopp, Norman

AU - Kolcic, Ivana

AU - Kutalik, Zoltan

AU - Lawlor, Debbie A.

AU - Musk, Arthur W.

AU - Pehlic, Marina

AU - Pennell, Craig E.

AU - Perry, John R. B.

AU - Peters, Annette

AU - Polasek, Ozren

AU - St Pourcain, Beate

AU - Ring, Susan M.

AU - Salvi, Erika

AU - Schipf, Sabine

AU - Staessen, Jan A.

AU - Teumer, Alexander

AU - Timpson, Nicholas

AU - Vitart, Veronique

AU - Warrington, Nicole M.

AU - Yaghootkar, Hanieh

AU - Zemunik, Tatijana

AU - Zgaga, Lina

AU - An, Ping

AU - Anttila, Verneri

AU - Borecki, Ingrid B.

AU - Holmen, Jostein

AU - Ntalla, Ioanna

AU - Palotie, Aarno

AU - Pietilainen, Kirsi H.

AU - Wedenoja, Juho

AU - Winsvold, Bendik S.

AU - Dedoussis, George V.

AU - Kaprio, Jaakko

AU - Province, Michael A.

AU - Zwart, John-Anker

AU - Burnier, Michel

AU - Campbell, Harry

AU - Cusi, Daniele

AU - Smith, George Davey

AU - Frayling, Timothy M.

AU - Gieger, Christian

AU - Palmer, Lyle J.

AU - Pramstaller, Peter P.

AU - Rudan, Igor

AU - Voelzke, Henry

AU - Wichmann, H. Erich

AU - Wright, Alan F.

AU - Zeggini, Eleftheria

PY - 2012/3/29

Y1 - 2012/3/29

N2 - Brachial circumference (BC), also known as upper arm or mid arm circumference, can be used as an indicator of muscle mass and fat tissue, which are distributed differently in men and women. Analysis of anthropometric measures of peripheral fat distribution such as BC could help in understanding the complex pathophysiology behind overweight and obesity. The purpose of this study is to identify genetic variants associated with BC through a large-scale genome-wide association scan (GWAS) meta-analysis. We used fixed-effects meta-analysis to synthesise summary results across 14 GWAS discovery and 4 replication cohorts comprising overall 22,376 individuals (12,031 women and 10,345 men) of European ancestry. Individual analyses were carried out for men, women, and combined across sexes using linear regression and an additive genetic model: adjusted for age and adjusted for age and BMI. We prioritised signals for follow-up in two-stages. We did not detect any signals reaching genome-wide significance. The FTO rs9939609 SNP showed nominal evidence for association (p

AB - Brachial circumference (BC), also known as upper arm or mid arm circumference, can be used as an indicator of muscle mass and fat tissue, which are distributed differently in men and women. Analysis of anthropometric measures of peripheral fat distribution such as BC could help in understanding the complex pathophysiology behind overweight and obesity. The purpose of this study is to identify genetic variants associated with BC through a large-scale genome-wide association scan (GWAS) meta-analysis. We used fixed-effects meta-analysis to synthesise summary results across 14 GWAS discovery and 4 replication cohorts comprising overall 22,376 individuals (12,031 women and 10,345 men) of European ancestry. Individual analyses were carried out for men, women, and combined across sexes using linear regression and an additive genetic model: adjusted for age and adjusted for age and BMI. We prioritised signals for follow-up in two-stages. We did not detect any signals reaching genome-wide significance. The FTO rs9939609 SNP showed nominal evidence for association (p

U2 - 10.1371/journal.pone.0031369

DO - 10.1371/journal.pone.0031369

M3 - Article

C2 - 22479309

SN - 1932-6203

VL - 7

JO - PLOS ONE

JF - PLOS ONE

IS - 3

M1 - e31369

ER -