Abstract
Original language | English |
---|---|
Pages (from-to) | 969-U77 |
Journal | Nature Genetics |
Volume | 43 |
Issue number | 10 |
DOIs | |
Publication status | Published - Oct 2011 |
Access to Document
Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver
}
In: Nature Genetics, Vol. 43, No. 10, 10.2011, p. 969-U77.
Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Genome-wide association study identifies five new schizophrenia loci
AU - Ripke, Stephan
AU - Sanders, Alan R.
AU - Kendler, Kenneth S.
AU - Levinson, Douglas F.
AU - Sklar, Pamela
AU - Holmans, Peter A.
AU - Lin, Dan-Yu
AU - Duan, Jubao
AU - Ophoff, Roel A.
AU - Andreassen, Ole A.
AU - Scolnick, Edward M.
AU - Cichon, Sven
AU - Clair, David St.
AU - Corvin, Aiden
AU - Gurling, Hugh
AU - Werge, Thomas
AU - Rujescu, Dan
AU - Blackwood, Douglas H. R.
AU - Pato, Carlos N.
AU - Malhotra, Anil K.
AU - Purcell, Shaun M.
AU - Dudbridge, Frank
AU - Neale, Benjamin M.
AU - Rossin, Lizzy
AU - Visscher, Peter M.
AU - Posthuma, Danielle
AU - Ruderfer, Douglas M.
AU - Fanous, Ayman H.
AU - Stefansson, Hreinn
AU - Steinberg, Stacy
AU - Mowry, Bryan J.
AU - Golimbet, Vera
AU - De Hert, Marc
AU - Jonsson, Erik G.
AU - Bitter, Istvan
AU - Pietilainen, Olli P. H.
AU - Collier, David A.
AU - Tosato, Sarah
AU - Agartz, Ingrid
AU - Albus, Margot
AU - Alexander, Madeline
AU - Amdur, Richard L.
AU - Amin, Farooq
AU - Bass, Nicholas
AU - Bergen, Sarah E.
AU - Black, Donald W.
AU - Borglum, Anders D.
AU - Brown, Matthew A.
AU - Bruggeman, Richard
AU - Buccola, Nancy G.
AU - Byerley, William F.
AU - Cahn, Wiepke
AU - Cantor, Rita M.
AU - Carr, Vaughan J.
AU - Catts, Stanley V.
AU - Choudhury, Khalid
AU - Cloninger, C. Robert
AU - Cormican, Paul
AU - Craddock, Nicholas
AU - Danoy, Patrick A.
AU - Datta, Susmita
AU - de Haan, Lieuwe
AU - Demontis, Ditte
AU - Dikeos, Dimitris
AU - Djurovic, Srdjan
AU - Donnelly, Peter
AU - Donohoe, Gary
AU - Duong, Linh
AU - Dwyer, Sarah
AU - Fink-Jensen, Anders
AU - Freedman, Robert
AU - Freimer, Nelson B.
AU - Friedl, Marion
AU - Georgieva, Lyudmila
AU - Giegling, Ina
AU - Gill, Michael
AU - Glenthoj, Birte
AU - Godard, Stephanie
AU - Hamshere, Marian L.
AU - Hansen, Mark
AU - Hansen, Thomas
AU - Hartmann, Annette M.
AU - Henskens, Frans A.
AU - Hougaard, David M.
AU - Hultman, Christina M.
AU - Ingason, Andres
AU - Jablensky, Assen V.
AU - Jakobsen, Klaus D.
AU - Jay, Maurice
AU - Juergens, Gesche
AU - Kahn, Renes
AU - Keller, Matthew C.
AU - Kenis, Gunter
AU - Kenny, Elaine
AU - Kim, Yunjung
AU - Kirov, George K.
AU - Konnerth, Heike
AU - Konte, Bettina
AU - Krabbendam, Lydia
AU - Krasucki, Robert
AU - Lasseter, Virginia K.
AU - Laurent, Claudine
AU - Lawrence, Jacob
AU - Lencz, Todd
AU - Lerer, F. Bernard
AU - Liang, Kung-Yee
AU - Lichtenstein, Paul
AU - Lieberman, Jeffrey A.
AU - Linszen, Don H.
AU - Lonnqvist, Jouko
AU - Loughland, Carmel M.
AU - Maclean, Alan W.
AU - Maher, Brion S.
AU - Maier, Wolfgang
AU - Mallet, Jacques
AU - Malloy, Pat
AU - Mattheisen, Manuel
AU - Mattingsdal, Morten
AU - McGhee, Kevin A.
AU - McGrath, John
AU - McIntosh, Andrew
AU - McLean, Duncan E.
AU - McQuillin, Andrew
AU - Melle, Ingrid
AU - Michie, Patricia T.
AU - Milanova, Vihra
AU - Morris, Derek W.
AU - Mors, Ole
AU - Mortensen, Preben B.
AU - Moskvina, Valentina
AU - Muglia, Pierandrea
AU - Myin-Germeys, Inez
AU - Nertney, Deborah A.
AU - Nestadt, Gerald
AU - Nielsen, Jimmi
AU - Nikolov, Ivan
AU - Nordentoft, Merete
AU - Norton, Nadine
AU - Noethen, Markus M.
AU - O'Dushlaine, Colm T.
AU - Olincy, Ann
AU - Olsen, Line
AU - O'Neill, F. Anthony
AU - Orntoft, Torben F.
AU - Owen, Michael J.
AU - Pantelis, Christos
AU - Papadimitriou, George N.
AU - Pato, Michele T.
AU - Peltonen, Leena
AU - Petursson, Hannes
AU - Pickard, Ben
AU - Pimm, Jonathan
AU - Pulver, Ann E.
AU - Puri, Vinay
AU - Quested, Digby
AU - Quinn, Emma M.
AU - Rasmussen, Henrik B.
AU - Rethelyi, Janos M.
AU - Ribble, Robert
AU - Rietschel, Marcella
AU - Riley, Brien P.
AU - Ruggeri, Mirella
AU - Schall, Ulrich
AU - Schulze, Thomas G.
AU - Schwab, Sibylle G.
AU - Scott, Rodney J.
AU - Shi, Jianxin
AU - Sigurdsson, Engilbert
AU - Silverman, Jeremy M.
AU - Spencer, Chris C. A.
AU - Stefansson, Kari
AU - Strange, Amy
AU - Strengman, Eric
AU - Stroup, T. Scott
AU - Suvisaari, Jaana
AU - Terenius, Lars
AU - Thirumalai, Srinivasa
AU - Thygesen, Johan H.
AU - Timm, Sally
AU - Toncheva, Draga
AU - Van den Oord, Edwin J. C. G.
AU - van Os, Jim
AU - van Winkel, Ruud
AU - Veldink, Jan H.
AU - Walsh, Dermot
AU - Wang, August G.
AU - Wiersma, Durk
AU - Wildenauer, Dieter B.
AU - Williams, Hywel J.
AU - Williams, Nigel M.
AU - Wormley, Brandon K.
AU - Zammit, Stan
AU - Sullivan, Patrick F.
AU - O'Donovan, Michael C.
AU - Daly, Mark J.
AU - Gejman, Pablo V.
PY - 2011/10
Y1 - 2011/10
N2 - We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication sample of 29,839 independent subjects. The combined stage 1 and 2 analysis yielded genome-wide significant associations with schizophrenia for seven loci, five of which are new (1p21.3, 2q32.3, 8p23.2, 8q21.3 and 10q24.32-q24.33) and two of which have been previously implicated (6p21.32-p22.1 and 18q21.2). The strongest new finding (P = 1.6 x 10(-11)) was with rs1625579 within an intron of a putative primary transcript for MIR137 (microRNA 137), a known regulator of neuronal development. Four other schizophrenia loci achieving genome-wide significance contain predicted targets of MIR137, suggesting MIR137-mediated dysregulation as a previously unknown etiologic mechanism in schizophrenia. In a joint analysis with a bipolar disorder sample (16,374 affected individuals and 14,044 controls), three loci reached genome-wide significance: CACNA1C (rs4765905, P = 7.0 x 10(-9)), ANK3 (rs10994359, P = 2.5 x 10(-8)) and the ITIH3-ITIH4 region (rs2239547, P = 7.8 x 10(-9)).
AB - We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication sample of 29,839 independent subjects. The combined stage 1 and 2 analysis yielded genome-wide significant associations with schizophrenia for seven loci, five of which are new (1p21.3, 2q32.3, 8p23.2, 8q21.3 and 10q24.32-q24.33) and two of which have been previously implicated (6p21.32-p22.1 and 18q21.2). The strongest new finding (P = 1.6 x 10(-11)) was with rs1625579 within an intron of a putative primary transcript for MIR137 (microRNA 137), a known regulator of neuronal development. Four other schizophrenia loci achieving genome-wide significance contain predicted targets of MIR137, suggesting MIR137-mediated dysregulation as a previously unknown etiologic mechanism in schizophrenia. In a joint analysis with a bipolar disorder sample (16,374 affected individuals and 14,044 controls), three loci reached genome-wide significance: CACNA1C (rs4765905, P = 7.0 x 10(-9)), ANK3 (rs10994359, P = 2.5 x 10(-8)) and the ITIH3-ITIH4 region (rs2239547, P = 7.8 x 10(-9)).
U2 - 10.1038/ng.940
DO - 10.1038/ng.940
M3 - Article
C2 - 21926974
SN - 1061-4036
VL - 43
SP - 969-U77
JO - Nature Genetics
JF - Nature Genetics
IS - 10
ER -