TY - JOUR
T1 - Genome-wide association analysis identifies 13 new risk loci for schizophrenia
AU - Ripke, Stephan
AU - O'Dushlaine, Colm
AU - Chambert, Kimberly D.
AU - Moran, Jennifer L.
AU - Kaehler, Anna K.
AU - Akterin, Susanne
AU - Bergen, Sarah E.
AU - Collins, Ann L.
AU - Crowley, James J.
AU - Fromer, Menachem
AU - Kim, Yunjung
AU - Lee, Sang Hong
AU - Magnusson, Patrik K. E.
AU - Sanchez, Nick
AU - Stahl, Eli A.
AU - Williams, Stephanie
AU - Wray, Naomi R.
AU - Xia, Kai
AU - Bettella, Francesco
AU - Borglum, Anders D.
AU - Bulik-Sullivan, Brendan K.
AU - Cormican, Paul
AU - Craddock, Nick
AU - de Leeuw, Christiaan
AU - Durmishi, Naser
AU - Gill, Michael
AU - Golimbet, Vera
AU - Hamshere, Marian L.
AU - Holmans, Peter A.
AU - Hougaard, David M.
AU - Kendler, Kenneth S.
AU - Lin, Kuang
AU - Morris, Derek W.
AU - Mors, Ole
AU - Mortensen, Preben B.
AU - Neale, Benjamin M.
AU - O'Neill, Francis A.
AU - Owen, Michael J.
AU - Milovancevic, Milica Pejovic
AU - Posthuma, Danielle
AU - Powell, John
AU - Richards, Alexander L.
AU - Riley, Brien P.
AU - Ruderfer, Douglas M.
AU - Rujescu, Dan
AU - Sigurdsson, Engilbert
AU - Multictr Genetic Studies Schizophr
AU - van Os, Jim
AU - Germeys, Inez
AU - Linszen, Don
AU - Bruggeman, Richard
PY - 2013/10
Y1 - 2013/10
N2 - Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and 6,243 controls) followed by meta-analysis with previous schizophrenia GWAS (8,832 cases and 12,067 controls) and finally by replication of SNPs in 168 genomic regions in independent samples (7,413 cases, 19,762 controls and 581 parent-offspring trios). We identified 22 loci associated at genome-wide significance; 13 of these are new, and 1 was previously implicated in bipolar disorder. Examination of candidate genes at these loci suggests the involvement of neuronal calcium signaling. We estimate that 8,300 independent, mostly common SNPs (95% credible interval of 6,300-10,200 SNPs) contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability. Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder.
AB - Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and 6,243 controls) followed by meta-analysis with previous schizophrenia GWAS (8,832 cases and 12,067 controls) and finally by replication of SNPs in 168 genomic regions in independent samples (7,413 cases, 19,762 controls and 581 parent-offspring trios). We identified 22 loci associated at genome-wide significance; 13 of these are new, and 1 was previously implicated in bipolar disorder. Examination of candidate genes at these loci suggests the involvement of neuronal calcium signaling. We estimate that 8,300 independent, mostly common SNPs (95% credible interval of 6,300-10,200 SNPs) contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability. Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder.
U2 - 10.1038/ng.2742
DO - 10.1038/ng.2742
M3 - Article
C2 - 23974872
SN - 1061-4036
VL - 45
SP - 1150
EP - 1159
JO - Nature Genetics
JF - Nature Genetics
IS - 10
ER -