Genome-Wide Analyses of Aggressiveness in Attention-Deficit Hyperactivity Disorder

Erlend J. Brevik*, Marjolein M. J. van Donkelaar, Heike Weber, Cristina Sanchez-Mora, Christian Jacob, Olga Rivero, Sarah Kittel-Schneider, Iris Garcia-Martinez, Marcel Aebi, Kimm van Hulzen, Bru Cormand, Josep A. Ramos-Quiroga, Klaus-Peter Lesch, Andreas Reif, Marta Ribases, Barbara Franke, Maj-Britt Posserud, Stefan Johansson, Astri J. Lundervold, Jan HaavikTetyana Zayats*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

28 Citations (Web of Science)

Abstract

Aggressiveness is a behavioral trait that has the potential to be harmful to individuals and society. With an estimated heritability of about 40%, genetics is important in its development. We performed an exploratory genome-wide association (GWA) analysis of childhood aggressiveness in attention deficit hyperactivity disorder (ADHD) to gain insight into the underlying biological processes associated with this trait. Our primary sample consisted of 1,060 adult ADHD patients (aADHD). To further explore the genetic architecture of childhood aggressiveness, we performed enrichment analyses of suggestive genome-wide associations observed in aADHD among GWA signals of dimensions of oppositionality (defiant/vindictive and irritable dimensions) in childhood ADHD (cADHD). No single polymorphism reached genome-wide significance (P
Original languageEnglish
Pages (from-to)733-747
JournalAmerican Journal of Medical Genetics Part B-neuropsychiatric Genetics
Volume171
Issue number5
DOIs
Publication statusPublished - Jul 2016

Keywords

  • ADHD
  • aggression
  • GWAS

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