TY - JOUR
T1 - Genome-Wide Analyses of Aggressiveness in Attention-Deficit Hyperactivity Disorder
AU - Brevik, Erlend J.
AU - van Donkelaar, Marjolein M. J.
AU - Weber, Heike
AU - Sanchez-Mora, Cristina
AU - Jacob, Christian
AU - Rivero, Olga
AU - Kittel-Schneider, Sarah
AU - Garcia-Martinez, Iris
AU - Aebi, Marcel
AU - van Hulzen, Kimm
AU - Cormand, Bru
AU - Ramos-Quiroga, Josep A.
AU - Lesch, Klaus-Peter
AU - Reif, Andreas
AU - Ribases, Marta
AU - Franke, Barbara
AU - Posserud, Maj-Britt
AU - Johansson, Stefan
AU - Lundervold, Astri J.
AU - Haavik, Jan
AU - Zayats, Tetyana
PY - 2016/7
Y1 - 2016/7
N2 - Aggressiveness is a behavioral trait that has the potential to be harmful to individuals and society. With an estimated heritability of about 40%, genetics is important in its development. We performed an exploratory genome-wide association (GWA) analysis of childhood aggressiveness in attention deficit hyperactivity disorder (ADHD) to gain insight into the underlying biological processes associated with this trait. Our primary sample consisted of 1,060 adult ADHD patients (aADHD). To further explore the genetic architecture of childhood aggressiveness, we performed enrichment analyses of suggestive genome-wide associations observed in aADHD among GWA signals of dimensions of oppositionality (defiant/vindictive and irritable dimensions) in childhood ADHD (cADHD). No single polymorphism reached genome-wide significance (P
AB - Aggressiveness is a behavioral trait that has the potential to be harmful to individuals and society. With an estimated heritability of about 40%, genetics is important in its development. We performed an exploratory genome-wide association (GWA) analysis of childhood aggressiveness in attention deficit hyperactivity disorder (ADHD) to gain insight into the underlying biological processes associated with this trait. Our primary sample consisted of 1,060 adult ADHD patients (aADHD). To further explore the genetic architecture of childhood aggressiveness, we performed enrichment analyses of suggestive genome-wide associations observed in aADHD among GWA signals of dimensions of oppositionality (defiant/vindictive and irritable dimensions) in childhood ADHD (cADHD). No single polymorphism reached genome-wide significance (P
KW - ADHD
KW - aggression
KW - GWAS
U2 - 10.1002/ajmg.b.32434
DO - 10.1002/ajmg.b.32434
M3 - Article
C2 - 27021288
SN - 1552-4841
VL - 171
SP - 733
EP - 747
JO - American Journal of Medical Genetics Part B-neuropsychiatric Genetics
JF - American Journal of Medical Genetics Part B-neuropsychiatric Genetics
IS - 5
ER -