Geniş Psikoz Fenotipinin COMT val158met ve BDNF val66met Polimorfizmleri ile İlişkisi

Tolga Binbay; Umut Kirli; Emre Misir; Hayriye Elbi; Bulent Kayahan; Huseyin Onay; Ferda Ozkinay; Marjan Drukker; Jim van Os; Koksal Alptekin

doi:10.5080/u19426

Geniş Psikoz Fenotipinin COMT val158met ve BDNF val66met Polimorfizmleri ile İlişkisi

Translated title of the contribution: The Association Between The Extended Psychosis Phenotype and COMT val158met and BDNF val66met Polymorphisms

Tolga Binbay^*, Umut Kirli, Emre Misir, Hayriye Elbi, Bulent Kayahan, Huseyin Onay, Ferda Ozkinay, Marjan Drukker, Jim van Os, Koksal Alptekin

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective: Psychotic disorders were previously associated with catechol-O-methyltransferase (COMT) val(158)met (rs4680) and brain-derived neurotrophic factor (BDNF) val(66) met (rs6265) polymorphisms. This article evaluates the association between COMT/BDNF polymorphisms and the extended psychosis phenotype which covers not only schizophrenia but also subclinical expressions of psychotic experiences.

Method: The participants of this study were part of the TurkSch (Izmir Mental Health Survey for Gene-Environment Interaction in Psychoses), a longitudinal study Psychotic experiences and disorders were screened 437. The extended psychosis phenotype was grouped into four: (1) no psychotic experiences (n: 194), (2) subclinical psychotic experiences (n: 87), (3) clinically relevant psychotic experiences (n: 104), and (4) schizophrenia-like disorders (n: 52). BDNF rs6265 was genotyped occurred in every participant whereas COMT rs4680 genotyping could be done on 366 individuals.

Results: There was no association between the extended psychosis phenotype and BDNF rs6265/COMT rs4680 polymorphisms. The frequency of met carriers in the BDNF rs6265genotype was slightly higher in individuals with subclinical psychotic experiences than in the group with no psychotic experiences, which was just below the significance level (p=0.08).

Conclusion: The lack of an association between different expression levels of the extended psychosis phenotype and the BDNF rs6265/COMT rs4680 polymorphism might be related to sample characteristics, underlying gene-gene, gene-environment and gene-environment-gene interactions.

Translated title of the contribution	The Association Between The Extended Psychosis Phenotype and COMT val158met and BDNF val66met Polymorphisms
Original language	Turkish
Pages (from-to)	1-8
Number of pages	8
Journal	Turkish Journal of Psychiatry
Volume	29
Issue number	4
DOIs	https://doi.org/10.5080/u19426
Publication status	Published - 2018

Keywords

Psychosis
schizophrenia
COMT
BDNF
genetics
O-METHYLTRANSFERASE COMT
FUNCTIONAL POLYMORPHISM
GENERAL-POPULATION
PREFRONTAL CORTEX
SCHIZOPHRENIA
RISK
METAANALYSIS
ENVIRONMENT
SYMPTOMS
DISORDER

Access to Document

10.5080/u19426

Cite this

@article{4bd2e110547c4bbabd508d2ad6765b8d,

title = "Geni{\c s} Psikoz Fenotipinin COMT val158met ve BDNF val66met Polimorfizmleri ile İli{\c s}kisi",

abstract = "Objective: Psychotic disorders were previously associated with catechol-O-methyltransferase (COMT) val(158)met (rs4680) and brain-derived neurotrophic factor (BDNF) val(66) met (rs6265) polymorphisms. This article evaluates the association between COMT/BDNF polymorphisms and the extended psychosis phenotype which covers not only schizophrenia but also subclinical expressions of psychotic experiences.Method: The participants of this study were part of the TurkSch (Izmir Mental Health Survey for Gene-Environment Interaction in Psychoses), a longitudinal study Psychotic experiences and disorders were screened 437. The extended psychosis phenotype was grouped into four: (1) no psychotic experiences (n: 194), (2) subclinical psychotic experiences (n: 87), (3) clinically relevant psychotic experiences (n: 104), and (4) schizophrenia-like disorders (n: 52). BDNF rs6265 was genotyped occurred in every participant whereas COMT rs4680 genotyping could be done on 366 individuals.Results: There was no association between the extended psychosis phenotype and BDNF rs6265/COMT rs4680 polymorphisms. The frequency of met carriers in the BDNF rs6265genotype was slightly higher in individuals with subclinical psychotic experiences than in the group with no psychotic experiences, which was just below the significance level (p=0.08).Conclusion: The lack of an association between different expression levels of the extended psychosis phenotype and the BDNF rs6265/COMT rs4680 polymorphism might be related to sample characteristics, underlying gene-gene, gene-environment and gene-environment-gene interactions.",

keywords = "Psychosis, schizophrenia, COMT, BDNF, genetics, O-METHYLTRANSFERASE COMT, FUNCTIONAL POLYMORPHISM, GENERAL-POPULATION, PREFRONTAL CORTEX, SCHIZOPHRENIA, RISK, METAANALYSIS, ENVIRONMENT, SYMPTOMS, DISORDER",

author = "Tolga Binbay and Umut Kirli and Emre Misir and Hayriye Elbi and Bulent Kayahan and Huseyin Onay and Ferda Ozkinay and Marjan Drukker and {van Os}, Jim and Koksal Alptekin",

year = "2018",

doi = "10.5080/u19426",

language = "Turkish",

volume = "29",

pages = "1--8",

journal = "Turkish Journal of Psychiatry",

issn = "1300-2163",

publisher = "T{\"u}rkiye Sinir ve Ruh Sağlığı Derneği",

number = "4",

}

TY - JOUR

T1 - Geniş Psikoz Fenotipinin COMT val158met ve BDNF val66met Polimorfizmleri ile İlişkisi

AU - Binbay, Tolga

AU - Kirli, Umut

AU - Misir, Emre

AU - Elbi, Hayriye

AU - Kayahan, Bulent

AU - Onay, Huseyin

AU - Ozkinay, Ferda

AU - Drukker, Marjan

AU - van Os, Jim

AU - Alptekin, Koksal

PY - 2018

Y1 - 2018

N2 - Objective: Psychotic disorders were previously associated with catechol-O-methyltransferase (COMT) val(158)met (rs4680) and brain-derived neurotrophic factor (BDNF) val(66) met (rs6265) polymorphisms. This article evaluates the association between COMT/BDNF polymorphisms and the extended psychosis phenotype which covers not only schizophrenia but also subclinical expressions of psychotic experiences.Method: The participants of this study were part of the TurkSch (Izmir Mental Health Survey for Gene-Environment Interaction in Psychoses), a longitudinal study Psychotic experiences and disorders were screened 437. The extended psychosis phenotype was grouped into four: (1) no psychotic experiences (n: 194), (2) subclinical psychotic experiences (n: 87), (3) clinically relevant psychotic experiences (n: 104), and (4) schizophrenia-like disorders (n: 52). BDNF rs6265 was genotyped occurred in every participant whereas COMT rs4680 genotyping could be done on 366 individuals.Results: There was no association between the extended psychosis phenotype and BDNF rs6265/COMT rs4680 polymorphisms. The frequency of met carriers in the BDNF rs6265genotype was slightly higher in individuals with subclinical psychotic experiences than in the group with no psychotic experiences, which was just below the significance level (p=0.08).Conclusion: The lack of an association between different expression levels of the extended psychosis phenotype and the BDNF rs6265/COMT rs4680 polymorphism might be related to sample characteristics, underlying gene-gene, gene-environment and gene-environment-gene interactions.

AB - Objective: Psychotic disorders were previously associated with catechol-O-methyltransferase (COMT) val(158)met (rs4680) and brain-derived neurotrophic factor (BDNF) val(66) met (rs6265) polymorphisms. This article evaluates the association between COMT/BDNF polymorphisms and the extended psychosis phenotype which covers not only schizophrenia but also subclinical expressions of psychotic experiences.Method: The participants of this study were part of the TurkSch (Izmir Mental Health Survey for Gene-Environment Interaction in Psychoses), a longitudinal study Psychotic experiences and disorders were screened 437. The extended psychosis phenotype was grouped into four: (1) no psychotic experiences (n: 194), (2) subclinical psychotic experiences (n: 87), (3) clinically relevant psychotic experiences (n: 104), and (4) schizophrenia-like disorders (n: 52). BDNF rs6265 was genotyped occurred in every participant whereas COMT rs4680 genotyping could be done on 366 individuals.Results: There was no association between the extended psychosis phenotype and BDNF rs6265/COMT rs4680 polymorphisms. The frequency of met carriers in the BDNF rs6265genotype was slightly higher in individuals with subclinical psychotic experiences than in the group with no psychotic experiences, which was just below the significance level (p=0.08).Conclusion: The lack of an association between different expression levels of the extended psychosis phenotype and the BDNF rs6265/COMT rs4680 polymorphism might be related to sample characteristics, underlying gene-gene, gene-environment and gene-environment-gene interactions.

KW - Psychosis

KW - schizophrenia

KW - COMT

KW - BDNF

KW - genetics

KW - O-METHYLTRANSFERASE COMT

KW - FUNCTIONAL POLYMORPHISM

KW - GENERAL-POPULATION

KW - PREFRONTAL CORTEX

KW - SCHIZOPHRENIA

KW - RISK

KW - METAANALYSIS

KW - ENVIRONMENT

KW - SYMPTOMS

KW - DISORDER

U2 - 10.5080/u19426

DO - 10.5080/u19426

M3 - Article

SN - 1300-2163

VL - 29

SP - 1

EP - 8

JO - Turkish Journal of Psychiatry

JF - Turkish Journal of Psychiatry

IS - 4

ER -