Genetics meets epigenetics: Genetic variants that modulate noncoding RNA in cardiovascular diseases

Martina Calore; Leon J. De Windt; Alessandra Rampazzo

doi:10.1016/j.yjmcc.2015.10.028

Genetics meets epigenetics: Genetic variants that modulate noncoding RNA in cardiovascular diseases

Martina Calore, Leon J. De Windt, Alessandra Rampazzo^*

^*Corresponding author for this work

Cardiologie

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

After the recent description of the human genome by the ENCODE and the FANTOM consortia, major attention has been addressed to the so-called "genomic noise", which mainly consists of noncoding RNAs (ncRNAs). Among them, microRNAs and long non-coding RNAs have been demonstrated to modulate gene expression and to be involved in several human diseases. Since ncRNAs and their targets are encoded in the genome, genetic principles apply. Common variants are supposed to influence the expression level and the functionality of ncRNAs, with subsequent differential regulation of their target genes. Moreover, several reports showed that polymorphisms in ncRNA or their target genes play a role in the development of cardiovascular adverse phenotype. Here, we provide an overview of the effects of these variations in cardiovascular diseases.

Original language	English
Pages (from-to)	27-34
Journal	Journal of Molecular and Cellular Cardiology
Volume	89
DOIs	https://doi.org/10.1016/j.yjmcc.2015.10.028
Publication status	Published - Dec 2015

Keywords

MiRNAs
Long noncoding RNAs
Cardiovascular diseases
Common genetic variants

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10.1016/j.yjmcc.2015.10.028

Cite this

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title = "Genetics meets epigenetics: Genetic variants that modulate noncoding RNA in cardiovascular diseases",

abstract = "After the recent description of the human genome by the ENCODE and the FANTOM consortia, major attention has been addressed to the so-called {"}genomic noise{"}, which mainly consists of noncoding RNAs (ncRNAs). Among them, microRNAs and long non-coding RNAs have been demonstrated to modulate gene expression and to be involved in several human diseases. Since ncRNAs and their targets are encoded in the genome, genetic principles apply. Common variants are supposed to influence the expression level and the functionality of ncRNAs, with subsequent differential regulation of their target genes. Moreover, several reports showed that polymorphisms in ncRNA or their target genes play a role in the development of cardiovascular adverse phenotype. Here, we provide an overview of the effects of these variations in cardiovascular diseases. ",

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T1 - Genetics meets epigenetics: Genetic variants that modulate noncoding RNA in cardiovascular diseases

AU - Calore, Martina

AU - De Windt, Leon J.

AU - Rampazzo, Alessandra

PY - 2015/12

Y1 - 2015/12

N2 - After the recent description of the human genome by the ENCODE and the FANTOM consortia, major attention has been addressed to the so-called "genomic noise", which mainly consists of noncoding RNAs (ncRNAs). Among them, microRNAs and long non-coding RNAs have been demonstrated to modulate gene expression and to be involved in several human diseases. Since ncRNAs and their targets are encoded in the genome, genetic principles apply. Common variants are supposed to influence the expression level and the functionality of ncRNAs, with subsequent differential regulation of their target genes. Moreover, several reports showed that polymorphisms in ncRNA or their target genes play a role in the development of cardiovascular adverse phenotype. Here, we provide an overview of the effects of these variations in cardiovascular diseases.

AB - After the recent description of the human genome by the ENCODE and the FANTOM consortia, major attention has been addressed to the so-called "genomic noise", which mainly consists of noncoding RNAs (ncRNAs). Among them, microRNAs and long non-coding RNAs have been demonstrated to modulate gene expression and to be involved in several human diseases. Since ncRNAs and their targets are encoded in the genome, genetic principles apply. Common variants are supposed to influence the expression level and the functionality of ncRNAs, with subsequent differential regulation of their target genes. Moreover, several reports showed that polymorphisms in ncRNA or their target genes play a role in the development of cardiovascular adverse phenotype. Here, we provide an overview of the effects of these variations in cardiovascular diseases.

KW - MiRNAs

KW - Long noncoding RNAs

KW - Cardiovascular diseases

KW - Common genetic variants

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DO - 10.1016/j.yjmcc.2015.10.028

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VL - 89

SP - 27

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JF - Journal of Molecular and Cellular Cardiology

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