Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes

Pooja R. Mandaviya, Roby Joehanes, Dylan Aissi, Brigitte Kuehnel, Riccardo E. Marioni, Vinh Truong, Lisette Stolk, Marian Beekman, Marc Jan Bonder, Lude Franke, Christian Gieger, Tianxiao Huan, M. Arfan Ikram, Sonja Kunze, Liming Liang, Jan Lindemann, Chunyu Liu, Allan F. McRae, Michael M. Mendelson, Martina Muller-NurasyidAnnette Peters, P. Eline Slagboom, John M. Starr, David -Alexandre Tregouet, Andre G. Uitterlinden, Marleen M. J. van Greevenbroek, Diana van Heemst, Maarten van Iterson, Philip S. Wells, Chen Yao, Ian J. Deary, France Gagnon, Bastiaan T. Heijmans, Daniel Levy, Pierre-Emmanuel Morange, Melanie Waldenberger, Sandra G. Heil, Joyce B. J. van Meurs*, Charge Consortium Epigenetics Grp

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number0182472
Number of pages19
JournalPLOS ONE
Volume12
Issue number10
DOIs
Publication statusPublished - 30 Oct 2017

Keywords

  • GENOME-WIDE ASSOCIATION
  • MENDELIAN RANDOMIZATION
  • FOLATE STATUS
  • INSTRUMENTAL VARIABLES
  • GENE-EXPRESSION
  • CANCER
  • METAANALYSIS
  • VARIANTS
  • REGION
  • RISK

Cite this

Mandaviya, P. R., Joehanes, R., Aissi, D., Kuehnel, B., Marioni, R. E., Truong, V., Stolk, L., Beekman, M., Bonder, M. J., Franke, L., Gieger, C., Huan, T., Ikram, M. A., Kunze, S., Liang, L., Lindemann, J., Liu, C., McRae, A. F., Mendelson, M. M., ... Charge Consortium Epigenetics Grp (2017). Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes. PLOS ONE, 12(10), [0182472]. https://doi.org/10.1371/journal.pone.0182472