Abstract
Intestinal cholesterol absorption varies widely between individuals, which may translate into differences in responsiveness to cholesterol-lowering drugs or diets. Therefore, understanding the importance of genetic variation on cholesterol absorption rates and the complex intestinal cholesterol network is important. Based on a systematic review, genetic variants in seven genes (ABCG5, ABCG8, ABO, APOE, MTTP, NPC1L1, and LDLR) were identified that were associated with intestinal cholesterol absorption. No clear associations were found for variants in APOA4, APOB, CETP, CYP7A1, HMGCR, SCARB1, SLCO1B1, and SREBF1. The seven genes were used to construct an intestinal cholesterol absorption network. Finally, a network with fifteen additional genes (APOA1, APOA4, APOB, APOC2, APOC3, CETP, HSPG2, LCAT, LDLRAP1, LIPC, LRP1, OLR1, P4HB, SAR1B, and SDC1) was generated. The constructed network shows that cholesterol absorption is complex. Further studies are needed to validate and improve this network, which may ultimately lead to a better understanding of the wide inter-individual variability in intestinal cholesterol absorption and the development of personalized interventions.
Original language | English |
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Article number | 101164 |
Number of pages | 10 |
Journal | Progress in Lipid Research |
Volume | 86 |
Early online date | 4 Apr 2022 |
DOIs | |
Publication status | Published - Apr 2022 |
Keywords
- ABCG8
- APOLIPOPROTEIN B-100 KINETICS
- Cholesterol absorption network
- DISEASE
- HEPATIC LIPASE
- Human
- Intestinal cholesterol absorption
- Isotopes
- METABOLISM
- NPC1L1
- PLANT STEROLS
- POLYMORPHISM
- PROMOTER VARIANT
- RISK
- Serum non-cholesterol sterols
- Single nucleotide polymorphisms