Genetic overlap among intelligence and other candidate endophenotypes for schizophrenia

M.F. Aukes; B.Z. Alizadeh; M.M. Sitskoorn; C. Kemner; R.A. Ophoff; R.S. Kahn

doi:10.1016/j.biopsych.2008.09.020

Genetic overlap among intelligence and other candidate endophenotypes for schizophrenia

M.F. Aukes^*
, B.Z. Alizadeh
, M.M. Sitskoorn
, C. Kemner
, R.A. Ophoff
, R.S. Kahn

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

A strategy to improve genetic studies of schizophrenia involves the use of endophenotypes. Information on overlapping genetic contributions among endophenotypes may provide additional power, reveal biological pathways, and have practical implications for genetic research. Several cognitive endophenotypes, including intelligence, are likely to be modulated by overlapping genetic influences.

Original language	English
Pages (from-to)	527
Journal	Biological Psychiatry
Volume	65
Issue number	6
DOIs	https://doi.org/10.1016/j.biopsych.2008.09.020
Publication status	Published - 1 Jan 2009

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title = "Genetic overlap among intelligence and other candidate endophenotypes for schizophrenia",

abstract = "A strategy to improve genetic studies of schizophrenia involves the use of endophenotypes. Information on overlapping genetic contributions among endophenotypes may provide additional power, reveal biological pathways, and have practical implications for genetic research. Several cognitive endophenotypes, including intelligence, are likely to be modulated by overlapping genetic influences.",

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AU - Ophoff, R.A.

AU - Kahn, R.S.

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N2 - A strategy to improve genetic studies of schizophrenia involves the use of endophenotypes. Information on overlapping genetic contributions among endophenotypes may provide additional power, reveal biological pathways, and have practical implications for genetic research. Several cognitive endophenotypes, including intelligence, are likely to be modulated by overlapping genetic influences.

AB - A strategy to improve genetic studies of schizophrenia involves the use of endophenotypes. Information on overlapping genetic contributions among endophenotypes may provide additional power, reveal biological pathways, and have practical implications for genetic research. Several cognitive endophenotypes, including intelligence, are likely to be modulated by overlapping genetic influences.

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DO - 10.1016/j.biopsych.2008.09.020

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SN - 0006-3223

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SP - 527

JO - Biological Psychiatry

JF - Biological Psychiatry

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Genetic overlap among intelligence and other candidate endophenotypes for schizophrenia

Abstract

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