Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

Phuwanat Sakornsakolpat, Dmitry Prokopenko, Maxime Lamontagne, Nicola F. Reeve, Anna L. Guyatt, Victoria E. Jackson, Nick Shrine, Dandi Qiao, Traci M. Bartz, Deog Kyeom Kim, Mi Kyeong Lee, Jeanne C. Latourelle, Xingnan Li, Jarrett D. Morrow, Ma'en Obeidat, Annah B. Wyss, Per Bakke, R. Graham Barr, Terri H. Beaty, Steven A. BelinskyGuy G. Brusselle, James D. Crapo, Kim de Jong, Dawn L. DeMeo, Tasha E. Fingerlin, Sina A. Gharib, Amund Gulsvik, Ian P. Hall, John E. Hokanson, Woo Jin Kim, David A. Lomas, Stephanie J. London, Deborah A. Meyers, George T. O'Connor, Stephen Rennard, David A. Schwartz, Pawel Sliwinski, David Sparrow, David P. Strachan, Ruth Tal-Singer, Yohannes Tesfaigzi, Jorgen Vestbo, Judith M. Vonk, Jae-Joon Yim, Xiaobo Zhou, Yohan Bosse, Ani Manichaikul, Hester Gietema, Gerben ter Riet, Emiel F. M. Wouters, SpiroMeta Consortium, International COPD Genetics Consortium, Understanding Society Scientific Group, Michael H. Cho*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

133 Citations (Web of Science)

Abstract

Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed a genome-wide association study in 35,735 cases and 222,076 controls from the UK Biobank and additional studies from the International COPD Genetics Consortium. We identified 82 loci associated with P <5 x 10(-8); 47 of these were previously described in association with either COPD or population-based measures of lung function. Of the remaining 35 new loci, 13 were associated with lung function in 79,055 individuals from the SpiroMeta consortium. Using gene expression and regulation data, we identified functional enrichment of COPD risk loci in lung tissue, smooth muscle, and several lung cell types. We found 14 COPD loci shared with either asthma or pulmonary fibrosis. COPD genetic risk loci clustered into groups based on associations with quantitative imaging features and comorbidities. Our analyses provide further support for the genetic susceptibility and heterogeneity of COPD.

Original languageEnglish
Pages (from-to)494-+
Number of pages14
JournalNature Genetics
Volume51
Issue number3
DOIs
Publication statusPublished - Mar 2019

Keywords

  • GENOME-WIDE ASSOCIATION
  • ACIDIC-MAMMALIAN-CHITINASE
  • LD SCORE REGRESSION
  • LUNG-FUNCTION
  • EXTRACELLULAR-MATRIX
  • PREDOMINANT EMPHYSEMA
  • CONNECTIVITY MAP
  • ATOPIC ASTHMA
  • RISK LOCI
  • GWAS

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