Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

Phuwanat Sakornsakolpat, Dmitry Prokopenko, Maxime Lamontagne, Nicola F. Reeve, Anna L. Guyatt, Victoria E. Jackson, Nick Shrine, Dandi Qiao, Traci M. Bartz, Deog Kyeom Kim, Mi Kyeong Lee, Jeanne C. Latourelle, Xingnan Li, Jarrett D. Morrow, Ma'en Obeidat, Annah B. Wyss, Per Bakke, R. Graham Barr, Terri H. Beaty, Steven A. BelinskyGuy G. Brusselle, James D. Crapo, Kim de Jong, Dawn L. DeMeo, Tasha E. Fingerlin, Sina A. Gharib, Amund Gulsvik, Ian P. Hall, John E. Hokanson, Woo Jin Kim, David A. Lomas, Stephanie J. London, Deborah A. Meyers, George T. O'Connor, Stephen Rennard, David A. Schwartz, Pawel Sliwinski, David Sparrow, David P. Strachan, Ruth Tal-Singer, Yohannes Tesfaigzi, Jorgen Vestbo, Judith M. Vonk, Jae-Joon Yim, Xiaobo Zhou, Yohan Bosse, Ani Manichaikul, Hester Gietema, Gerben ter Riet, Emiel F. M. Wouters, SpiroMeta Consortium, Int COPD Genetics Consortium, Understanding Soc Sci Grp

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)494-+
Number of pages14
JournalNature Genetics
Volume51
Issue number3
DOIs
Publication statusPublished - Mar 2019

Keywords

  • GENOME-WIDE ASSOCIATION
  • ACIDIC-MAMMALIAN-CHITINASE
  • LD SCORE REGRESSION
  • LUNG-FUNCTION
  • EXTRACELLULAR-MATRIX
  • PREDOMINANT EMPHYSEMA
  • CONNECTIVITY MAP
  • ATOPIC ASTHMA
  • RISK LOCI
  • GWAS

Cite this

Sakornsakolpat, P., Prokopenko, D., Lamontagne, M., Reeve, N. F., Guyatt, A. L., Jackson, V. E., Shrine, N., Qiao, D., Bartz, T. M., Kim, D. K., Lee, M. K., Latourelle, J. C., Li, X., Morrow, J. D., Obeidat, M., Wyss, A. B., Bakke, P., Barr, R. G., Beaty, T. H., ... Understanding Soc Sci Grp (2019). Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations. Nature Genetics, 51(3), 494-+. https://doi.org/10.1038/s41588-018-0342-2