Genetic counseling for prostate cancer risk

A.M. Nieder, S.S. Taneja, M.P.A. Zeegers, H. Ostrer

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Genetic counseling for prostate cancer risk.

Nieder AM, Taneja SS, Zeegers MP, Ostrer H.

Department of Urology and NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.

Major risk factors for developing prostate cancer, including positive family history and African-American ethnicity, can be quantified for genetic counseling. Factors increasing familial risk for prostate cancer are closer degree of kinship, number of affected relatives, and early age of onset (< 50 years) among the affected relatives. Genetic testing may be useful for modification of risk, but currently should be performed only within the context of a well-designed research study that will determine penetrance and genotype-phenotype correlation of specific mutations. Even in the absence of genetic testing, African-American men and men with a strong family history of prostate cancer may opt to initiate screening by prostate specific antigen (PSA) and digital rectal exam (DRE) screening at age 40. Copyright Blackwell Munksgaard, 2003
Original languageEnglish
Pages (from-to)169-176
Number of pages7
JournalClinical Genetics
Volume63
Issue number3
DOIs
Publication statusPublished - 1 Jan 2003

Cite this