Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes

E.L. Robinson; K. Alkass; O. Bergmann; J.J. Maguire; H.L. Roderick; A.P. Davenport

doi:10.1016/j.yjmcc.2020.08.009

Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes

E.L. Robinson, K. Alkass, O. Bergmann, J.J. Maguire, H.L. Roderick, A.P. Davenport^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

Original language	English
Pages (from-to)	88-91
Number of pages	4
Journal	Journal of Molecular and Cellular Cardiology
Volume	147
DOIs	https://doi.org/10.1016/j.yjmcc.2020.08.009
Publication status	Published - 1 Oct 2020

Keywords

angiotensin
apelin
bradykinin
covid-19
human cardiomyocytes
rna-sequencing
sars-cov-2
RNA-sequencing
COVID-19
SARS-CoV-2
Human cardiomyocytes
Bradykinin
Angiotensin
Apelin

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10.1016/j.yjmcc.2020.08.009

Cite this

@article{5a273822310c4457ae30e7a0aec472fc,

title = "Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes",

keywords = "angiotensin, apelin, bradykinin, covid-19, human cardiomyocytes, rna-sequencing, sars-cov-2, RNA-sequencing, COVID-19, SARS-CoV-2, Human cardiomyocytes, Bradykinin, Angiotensin, Apelin",

author = "E.L. Robinson and K. Alkass and O. Bergmann and J.J. Maguire and H.L. Roderick and A.P. Davenport",

note = "Funding Information: This work was supported by the Wellcome Trust 107715/Z/15/Z (UK), Addenbrooke's Charitable Trust (UK), British Heart Foundation Translational Award TG/18/4/33770 (A.P.D. & J.J.M.)(UK). Wellcome Trust PhD fellowship (Cardiovascular & Metabolic Disease)(UK), CVON EARLY-HFPEF consortium grant (Dutch Heart Foundation, Netherlands) and EMBO short-term fellowship (Ref 8471) (E.L.R). Research Foundation Flanders FWO (Fonds Wetenschappelijk Onderzoek) Odysseus Project Grant 90663, KULeuven Internal Funding (C1) (C14/17/088 (Belgium) and BBSRC Institute Strategic Program Grant (BBS/E/B/000C0400-403) (H.L.R.)(UK). The Center for Regenerative Therapies Dresden, the Karolinska Institutet, the Swedish Research Council, the Ragnar S{\"o}derberg Foundation, and the {\AA}ke Wiberg Foundation (O.B.)(Sweden). Funding Information: This work was supported by the Wellcome Trust 107715/Z/15/Z (UK), Addenbrooke's Charitable Trust (UK), British Heart Foundation Translational Award TG/18/4/33770 (A.P.D. & J.J.M.)(UK). Wellcome Trust PhD fellowship (Cardiovascular & Metabolic Disease)(UK), CVON EARLY-HFPEF consortium grant (Dutch Heart Foundation, Netherlands) and EMBO short-term fellowship (Ref 8471) (E.L.R). Research Foundation Flanders FWO (Fonds Wetenschappelijk Onderzoek) Odysseus Project Grant 90663, KULeuven Internal Funding (C1) (C14/17/088 (Belgium) and BBSRC Institute Strategic Program Grant (BBS/E/B/000C0400-403) (H.L.R.)(UK). The Center for Regenerative Therapies Dresden, the Karolinska Institutet, the Swedish Research Council, the Ragnar S?derberg Foundation, and the ?ke Wiberg Foundation (O.B.)(Sweden).",

year = "2020",

month = oct,

day = "1",

doi = "10.1016/j.yjmcc.2020.08.009",

language = "English",

volume = "147",

pages = "88--91",

journal = "Journal of Molecular and Cellular Cardiology",

issn = "0022-2828",

publisher = "ELSEVIER SCI LTD",

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TY - JOUR

T1 - Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes

AU - Robinson, E.L.

AU - Alkass, K.

AU - Bergmann, O.

AU - Maguire, J.J.

AU - Roderick, H.L.

AU - Davenport, A.P.

N1 - Funding Information: This work was supported by the Wellcome Trust 107715/Z/15/Z (UK), Addenbrooke's Charitable Trust (UK), British Heart Foundation Translational Award TG/18/4/33770 (A.P.D. & J.J.M.)(UK). Wellcome Trust PhD fellowship (Cardiovascular & Metabolic Disease)(UK), CVON EARLY-HFPEF consortium grant (Dutch Heart Foundation, Netherlands) and EMBO short-term fellowship (Ref 8471) (E.L.R). Research Foundation Flanders FWO (Fonds Wetenschappelijk Onderzoek) Odysseus Project Grant 90663, KULeuven Internal Funding (C1) (C14/17/088 (Belgium) and BBSRC Institute Strategic Program Grant (BBS/E/B/000C0400-403) (H.L.R.)(UK). The Center for Regenerative Therapies Dresden, the Karolinska Institutet, the Swedish Research Council, the Ragnar Söderberg Foundation, and the Åke Wiberg Foundation (O.B.)(Sweden). Funding Information: This work was supported by the Wellcome Trust 107715/Z/15/Z (UK), Addenbrooke's Charitable Trust (UK), British Heart Foundation Translational Award TG/18/4/33770 (A.P.D. & J.J.M.)(UK). Wellcome Trust PhD fellowship (Cardiovascular & Metabolic Disease)(UK), CVON EARLY-HFPEF consortium grant (Dutch Heart Foundation, Netherlands) and EMBO short-term fellowship (Ref 8471) (E.L.R). Research Foundation Flanders FWO (Fonds Wetenschappelijk Onderzoek) Odysseus Project Grant 90663, KULeuven Internal Funding (C1) (C14/17/088 (Belgium) and BBSRC Institute Strategic Program Grant (BBS/E/B/000C0400-403) (H.L.R.)(UK). The Center for Regenerative Therapies Dresden, the Karolinska Institutet, the Swedish Research Council, the Ragnar S?derberg Foundation, and the ?ke Wiberg Foundation (O.B.)(Sweden).

PY - 2020/10/1

Y1 - 2020/10/1

KW - angiotensin

KW - apelin

KW - bradykinin

KW - covid-19

KW - human cardiomyocytes

KW - rna-sequencing

KW - sars-cov-2

KW - RNA-sequencing

KW - COVID-19

KW - SARS-CoV-2

KW - Human cardiomyocytes

KW - Bradykinin

KW - Angiotensin

KW - Apelin

U2 - 10.1016/j.yjmcc.2020.08.009

DO - 10.1016/j.yjmcc.2020.08.009

M3 - Comment/Letter to the editor

C2 - 32818486

SN - 0022-2828

VL - 147

SP - 88

EP - 91

JO - Journal of Molecular and Cellular Cardiology

JF - Journal of Molecular and Cellular Cardiology

ER -