@article{0116705708744313a89eccfb02602893,
title = "Generation of multiple human iPSC lines from peripheral blood mononuclear cells of two SLC2A3 deletion and two SLC2A3 duplication carriers",
abstract = "Copy number variants of SLC2A3, which encodes the glucose transporter GLUT3, are associated with several neuropsychiatric and cardiac diseases. Here, we report the successful reprogramming of peripheral blood mononuclear cells from two SLC2A3 duplication and two SLC2A3 deletion carriers and subsequent generation of two transgene-free iPSC clones per donor by Sendai viral transduction. All eight clones represent bona fide hiPSCs with high expression of pluripotency genes, ability to differentiate into cells of all three germ layers and normal karyotype. The generated cell lines will be helpful to enlighten the role of glucometabolic alterations in pathophysiological processes shared across organ boundaries.",
keywords = "CONGENITAL HEART-DEFECTS, TRANSPORTER GENE SLC2A3, COPY-NUMBER VARIATION",
author = "G.C. Ziegler and F. Radtke and M.R. Vitale and A. Preusse and E. Klopocki and S. Herms and K.P. Lesch",
note = "Funding Information: This work was supported by ERA-NET NEURON under Grant No. 01EW1902 (DECODE!), the Horizon 2020 Research and Innovation Programme under Grant No. 728018 (Eat2beNICE) and the 5-100 Russian Academic Excellence Project. This publication was supported by the Open Access Publication Fund of the University of W{\"u}rzburg. G.C.Z is supported by a grant from the DFG (Project No. 413657723 Clinician Scientist-Program UNION CVD). We thank Julia Merk, Nicole Schraut, and Gabriela Ortega for excellent technical assistance. Funding Information: This work was supported by ERA-NET NEURON under Grant No. 01EW1902 (DECODE!), the Horizon 2020 Research and Innovation Programme under Grant No. 728018 (Eat2beNICE) and the 5-100 Russian Academic Excellence Project. This publication was supported by the Open Access Publication Fund of the University of W?rzburg. G.C.Z is supported by a grant from the DFG (Project No. 413657723 Clinician Scientist-Program UNION CVD). We thank Julia Merk, Nicole Schraut, and Gabriela Ortega for excellent technical assistance. Publisher Copyright: {\textcopyright} 2021 The Author(s)",
year = "2021",
month = oct,
day = "1",
doi = "10.1016/j.scr.2021.102526",
language = "English",
volume = "56",
journal = "Stem Cell Research",
issn = "1873-5061",
publisher = "Elsevier B.V.",
}