General practitioner use of a C-reactive protein point-of-care test to help target antibiotic prescribing in patients with acute exacerbations of chronic obstructive pulmonary disease (the PACE study): study protocol for a randomised controlled trial

Janine Bates; Nick A. Francis; Patrick White; David Gillespie; Emma Thomas-Jones; Rachel Breen; Nigel Kirby; Kerry Hood; Micaela Gal; Rhiannon Phillips; Gurudutt Naik; Jochen Cals; Carl Llor; Hasse Melbye; Mandy Wootton; Evgenia Riga; Ann Cochrane; Robin Howe; Deborah Fitzsimmons; Bernadette Sewell; Mohammed Fasihul Alam; Christopher C. Butler

doi:10.1186/s13063-017-2144-8

General practitioner use of a C-reactive protein point-of-care test to help target antibiotic prescribing in patients with acute exacerbations of chronic obstructive pulmonary disease (the PACE study): study protocol for a randomised controlled trial

Janine Bates^*, Nick A. Francis, Patrick White, David Gillespie, Emma Thomas-Jones, Rachel Breen, Nigel Kirby, Kerry Hood, Micaela Gal, Rhiannon Phillips, Gurudutt Naik, Jochen Cals, Carl Llor, Hasse Melbye, Mandy Wootton, Evgenia Riga, Ann Cochrane, Robin Howe, Deborah Fitzsimmons, Bernadette SewellMohammed Fasihul Alam, Christopher C. Butler

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Article number	442
Number of pages	15
Journal	Trials
Volume	18
DOIs	https://doi.org/10.1186/s13063-017-2144-8
Publication status	Published - 29 Sep 2017

Keywords

Acute exacerbation
Chronic obstructive pulmonary disease
Primary care
Point-of-care test
C-reactive protein (CRP)
Near-patient testing
Rationalising antibiotic prescribing
Antibiotic resistance
Cost-effectiveness
Resistance
RESPIRATORY-TRACT INFECTIONS
MULTIPLE END-POINTS
STREPTOCOCCUS-PNEUMONIAE
SYSTEMIC CORTICOSTEROIDS
COPD
RESISTANCE
THERAPY
PROCALCITONIN
PREDICTORS
BIOMARKERS

Access to Document

10.1186/s13063-017-2144-8

Cite this

Bates, J., Francis, N. A., White, P., Gillespie, D., Thomas-Jones, E., Breen, R., Kirby, N., Hood, K., Gal, M., Phillips, R., Naik, G., Cals, J., Llor, C., Melbye, H., Wootton, M., Riga, E., Cochrane, A., Howe, R., Fitzsimmons, D., ... Butler, C. C. (2017). General practitioner use of a C-reactive protein point-of-care test to help target antibiotic prescribing in patients with acute exacerbations of chronic obstructive pulmonary disease (the PACE study): study protocol for a randomised controlled trial. Trials, 18, [442]. https://doi.org/10.1186/s13063-017-2144-8

Bates, Janine ; Francis, Nick A. ; White, Patrick ; Gillespie, David ; Thomas-Jones, Emma ; Breen, Rachel ; Kirby, Nigel ; Hood, Kerry ; Gal, Micaela ; Phillips, Rhiannon ; Naik, Gurudutt ; Cals, Jochen ; Llor, Carl ; Melbye, Hasse ; Wootton, Mandy ; Riga, Evgenia ; Cochrane, Ann ; Howe, Robin ; Fitzsimmons, Deborah ; Sewell, Bernadette ; Alam, Mohammed Fasihul ; Butler, Christopher C. / General practitioner use of a C-reactive protein point-of-care test to help target antibiotic prescribing in patients with acute exacerbations of chronic obstructive pulmonary disease (the PACE study) : study protocol for a randomised controlled trial. In: Trials. 2017 ; Vol. 18.

@article{e7b7a473623a4f82b1f141428fd8868b,

title = "General practitioner use of a C-reactive protein point-of-care test to help target antibiotic prescribing in patients with acute exacerbations of chronic obstructive pulmonary disease (the PACE study): study protocol for a randomised controlled trial",

keywords = "Acute exacerbation, Chronic obstructive pulmonary disease, Primary care, Point-of-care test, C-reactive protein (CRP), Near-patient testing, Rationalising antibiotic prescribing, Antibiotic resistance, Cost-effectiveness, Resistance, RESPIRATORY-TRACT INFECTIONS, MULTIPLE END-POINTS, STREPTOCOCCUS-PNEUMONIAE, SYSTEMIC CORTICOSTEROIDS, COPD, RESISTANCE, THERAPY, PROCALCITONIN, PREDICTORS, BIOMARKERS",

author = "Janine Bates and Francis, {Nick A.} and Patrick White and David Gillespie and Emma Thomas-Jones and Rachel Breen and Nigel Kirby and Kerry Hood and Micaela Gal and Rhiannon Phillips and Gurudutt Naik and Jochen Cals and Carl Llor and Hasse Melbye and Mandy Wootton and Evgenia Riga and Ann Cochrane and Robin Howe and Deborah Fitzsimmons and Bernadette Sewell and Alam, {Mohammed Fasihul} and Butler, {Christopher C.}",

year = "2017",

month = sep,

day = "29",

doi = "10.1186/s13063-017-2144-8",

language = "English",

volume = "18",

journal = "Trials",

issn = "1745-6215",

publisher = "BioMed Central Ltd",

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Bates, J, Francis, NA, White, P, Gillespie, D, Thomas-Jones, E, Breen, R, Kirby, N, Hood, K, Gal, M, Phillips, R, Naik, G, Cals, J, Llor, C, Melbye, H, Wootton, M, Riga, E, Cochrane, A, Howe, R, Fitzsimmons, D, Sewell, B, Alam, MF & Butler, CC 2017, 'General practitioner use of a C-reactive protein point-of-care test to help target antibiotic prescribing in patients with acute exacerbations of chronic obstructive pulmonary disease (the PACE study): study protocol for a randomised controlled trial', Trials, vol. 18, 442. https://doi.org/10.1186/s13063-017-2144-8

General practitioner use of a C-reactive protein point-of-care test to help target antibiotic prescribing in patients with acute exacerbations of chronic obstructive pulmonary disease (the PACE study) : study protocol for a randomised controlled trial. / Bates, Janine; Francis, Nick A.; White, Patrick; Gillespie, David; Thomas-Jones, Emma; Breen, Rachel; Kirby, Nigel; Hood, Kerry; Gal, Micaela; Phillips, Rhiannon; Naik, Gurudutt; Cals, Jochen; Llor, Carl; Melbye, Hasse; Wootton, Mandy; Riga, Evgenia; Cochrane, Ann; Howe, Robin; Fitzsimmons, Deborah; Sewell, Bernadette; Alam, Mohammed Fasihul; Butler, Christopher C.

In: Trials, Vol. 18, 442, 29.09.2017.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - General practitioner use of a C-reactive protein point-of-care test to help target antibiotic prescribing in patients with acute exacerbations of chronic obstructive pulmonary disease (the PACE study)

T2 - study protocol for a randomised controlled trial

AU - Bates, Janine

AU - Francis, Nick A.

AU - White, Patrick

AU - Gillespie, David

AU - Thomas-Jones, Emma

AU - Breen, Rachel

AU - Kirby, Nigel

AU - Hood, Kerry

AU - Gal, Micaela

AU - Phillips, Rhiannon

AU - Naik, Gurudutt

AU - Cals, Jochen

AU - Llor, Carl

AU - Melbye, Hasse

AU - Wootton, Mandy

AU - Riga, Evgenia

AU - Cochrane, Ann

AU - Howe, Robin

AU - Fitzsimmons, Deborah

AU - Sewell, Bernadette

AU - Alam, Mohammed Fasihul

AU - Butler, Christopher C.

PY - 2017/9/29

Y1 - 2017/9/29

KW - Acute exacerbation

KW - Chronic obstructive pulmonary disease

KW - Primary care

KW - Point-of-care test

KW - C-reactive protein (CRP)

KW - Near-patient testing

KW - Rationalising antibiotic prescribing

KW - Antibiotic resistance

KW - Cost-effectiveness

KW - Resistance

KW - RESPIRATORY-TRACT INFECTIONS

KW - MULTIPLE END-POINTS

KW - STREPTOCOCCUS-PNEUMONIAE

KW - SYSTEMIC CORTICOSTEROIDS

KW - COPD

KW - RESISTANCE

KW - THERAPY

KW - PROCALCITONIN

KW - PREDICTORS

KW - BIOMARKERS

U2 - 10.1186/s13063-017-2144-8

DO - 10.1186/s13063-017-2144-8

M3 - Article

VL - 18

JO - Trials

JF - Trials

SN - 1745-6215

M1 - 442

ER -

Bates J, Francis NA, White P, Gillespie D, Thomas-Jones E, Breen R et al. General practitioner use of a C-reactive protein point-of-care test to help target antibiotic prescribing in patients with acute exacerbations of chronic obstructive pulmonary disease (the PACE study): study protocol for a randomised controlled trial. Trials. 2017 Sep 29;18. 442. https://doi.org/10.1186/s13063-017-2144-8