Abstract
Early-life exposures are critical in fetal programming and may influence function and health in later life. Adequate maternal folate consumption during pregnancy is essential for healthy fetal development and long-term offspring health. The mechanisms underlying fetal programming are poorly understood, but are likely to involve gene regulation. Epigenetic marks, including DNA methylation, regulate gene expression and are modifiable by folate supply. We observed transcriptional changes in fetal liver in response to maternal folate depletion and hypothesized that these changes are concomitant with altered gene promoter methylation.
Original language | English |
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Pages (from-to) | 2031-2042 |
Number of pages | 12 |
Journal | Molecular Nutrition & Food Research |
Volume | 60 |
Issue number | 9 |
DOIs | |
Publication status | Published - Sep 2016 |
Keywords
- Development
- DNA methylation
- Folate
- Gene expression
- Programming
- FOLIC-ACID SUPPLEMENTATION
- AUTISM SPECTRUM DISORDERS
- EPIGENETIC CHANGES
- DIETARY-INTAKE
- VITAMINS B6
- RISK
- DEFICIENCY
- CANCER
- HEALTH
- TISSUE