Gene promoter DNA methylation patterns have a limited role in orchestrating transcriptional changes in the fetal liver in response to maternal folate depletion during pregnancy.

Jill A McKay, Michiel Adriaens, Chris T Evelo, Dianne Ford, John C Mathers

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Abstract

Early-life exposures are critical in fetal programming and may influence function and health in later life. Adequate maternal folate consumption during pregnancy is essential for healthy fetal development and long-term offspring health. The mechanisms underlying fetal programming are poorly understood, but are likely to involve gene regulation. Epigenetic marks, including DNA methylation, regulate gene expression and are modifiable by folate supply. We observed transcriptional changes in fetal liver in response to maternal folate depletion and hypothesized that these changes are concomitant with altered gene promoter methylation.
Original languageEnglish
Pages (from-to)2031-2042
Number of pages12
JournalMolecular Nutrition & Food Research
Volume60
Issue number9
DOIs
Publication statusPublished - Sep 2016

Keywords

  • Development
  • DNA methylation
  • Folate
  • Gene expression
  • Programming
  • FOLIC-ACID SUPPLEMENTATION
  • AUTISM SPECTRUM DISORDERS
  • EPIGENETIC CHANGES
  • DIETARY-INTAKE
  • VITAMINS B6
  • RISK
  • DEFICIENCY
  • CANCER
  • HEALTH
  • TISSUE

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