Gene expression signature of Gleason score is associated with prostate cancer outcomes in a radical prostatectomy cohort

Min A. Jhun; Milan S. Geybels; Jonathan L. Wright; Suzanne Kolb; Craig April; Marina Bibikova; Elaine A. Ostrander; Jian-Bing Fan; Ziding Feng; Janet L. Stanford

doi:10.18632/oncotarget.17428

Gene expression signature of Gleason score is associated with prostate cancer outcomes in a radical prostatectomy cohort

Min A. Jhun
, Milan S. Geybels
, Jonathan L. Wright
, Suzanne Kolb
, Craig April
, Marina Bibikova
, Elaine A. Ostrander
, Jian-Bing Fan
, Ziding Feng
, Janet L. Stanford^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Prostate cancer (PCa) is a leading cause of cancer-related mortality worldwide. Gleason score (GS) is one of the best predictors of PCa aggressiveness, but additional tumor biomarkers may improve its prognostic accuracy. We developed a gene expression signature of GS to enhance the prediction of PCa outcomes. Elastic net was used to construct a gene expression signature by contrasting GS 8-10 vs.

Original language	English
Pages (from-to)	43035-43047
Number of pages	13
Journal	Oncotarget
Volume	8
Issue number	26
DOIs	https://doi.org/10.18632/oncotarget.17428
Publication status	Published - 27 Jun 2017

Keywords

gene expression
Gleason score
prostate cancer
recurrence
metastasis
NEEDLE-BIOPSY COHORT
GENOMIC CLASSIFIER
BIOCHEMICAL RECURRENCE
RISK STRATIFICATION
METASTATIC-DISEASE
PROGRESSION
VALIDATION
POPULATION
CARCINOMA
DEATH

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10.18632/oncotarget.17428Licence: CC BY

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title = "Gene expression signature of Gleason score is associated with prostate cancer outcomes in a radical prostatectomy cohort",

abstract = "Prostate cancer (PCa) is a leading cause of cancer-related mortality worldwide. Gleason score (GS) is one of the best predictors of PCa aggressiveness, but additional tumor biomarkers may improve its prognostic accuracy. We developed a gene expression signature of GS to enhance the prediction of PCa outcomes. Elastic net was used to construct a gene expression signature by contrasting GS 8-10 vs.",

keywords = "gene expression, Gleason score, prostate cancer, recurrence, metastasis, NEEDLE-BIOPSY COHORT, GENOMIC CLASSIFIER, BIOCHEMICAL RECURRENCE, RISK STRATIFICATION, METASTATIC-DISEASE, PROGRESSION, VALIDATION, POPULATION, CARCINOMA, DEATH",

author = "Jhun, \{Min A.\} and Geybels, \{Milan S.\} and Wright, \{Jonathan L.\} and Suzanne Kolb and Craig April and Marina Bibikova and Ostrander, \{Elaine A.\} and Jian-Bing Fan and Ziding Feng and Stanford, \{Janet L.\}",

year = "2017",

month = jun,

day = "27",

doi = "10.18632/oncotarget.17428",

language = "English",

volume = "8",

pages = "43035--43047",

journal = "Oncotarget",

issn = "1949-2553",

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TY - JOUR

T1 - Gene expression signature of Gleason score is associated with prostate cancer outcomes in a radical prostatectomy cohort

AU - Jhun, Min A.

AU - Geybels, Milan S.

AU - Wright, Jonathan L.

AU - Kolb, Suzanne

AU - April, Craig

AU - Bibikova, Marina

AU - Ostrander, Elaine A.

AU - Fan, Jian-Bing

AU - Feng, Ziding

AU - Stanford, Janet L.

PY - 2017/6/27

Y1 - 2017/6/27

N2 - Prostate cancer (PCa) is a leading cause of cancer-related mortality worldwide. Gleason score (GS) is one of the best predictors of PCa aggressiveness, but additional tumor biomarkers may improve its prognostic accuracy. We developed a gene expression signature of GS to enhance the prediction of PCa outcomes. Elastic net was used to construct a gene expression signature by contrasting GS 8-10 vs.

AB - Prostate cancer (PCa) is a leading cause of cancer-related mortality worldwide. Gleason score (GS) is one of the best predictors of PCa aggressiveness, but additional tumor biomarkers may improve its prognostic accuracy. We developed a gene expression signature of GS to enhance the prediction of PCa outcomes. Elastic net was used to construct a gene expression signature by contrasting GS 8-10 vs.

KW - gene expression

KW - Gleason score

KW - prostate cancer

KW - recurrence

KW - metastasis

KW - NEEDLE-BIOPSY COHORT

KW - GENOMIC CLASSIFIER

KW - BIOCHEMICAL RECURRENCE

KW - RISK STRATIFICATION

KW - METASTATIC-DISEASE

KW - PROGRESSION

KW - VALIDATION

KW - POPULATION

KW - CARCINOMA

KW - DEATH

U2 - 10.18632/oncotarget.17428

DO - 10.18632/oncotarget.17428

M3 - Article

SN - 1949-2553

VL - 8

SP - 43035

EP - 43047

JO - Oncotarget

JF - Oncotarget

IS - 26

ER -

Gene expression signature of Gleason score is associated with prostate cancer outcomes in a radical prostatectomy cohort

Abstract

Keywords

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