Gene expression signature of Gleason score is associated with prostate cancer outcomes in a radical prostatectomy cohort

Min A. Jhun, Milan S. Geybels, Jonathan L. Wright, Suzanne Kolb, Craig April, Marina Bibikova, Elaine A. Ostrander, Jian-Bing Fan, Ziding Feng, Janet L. Stanford*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Prostate cancer (PCa) is a leading cause of cancer-related mortality worldwide. Gleason score (GS) is one of the best predictors of PCa aggressiveness, but additional tumor biomarkers may improve its prognostic accuracy. We developed a gene expression signature of GS to enhance the prediction of PCa outcomes. Elastic net was used to construct a gene expression signature by contrasting GS 8-10 vs.

Original languageEnglish
Pages (from-to)43035-43047
Number of pages13
JournalOncotarget
Volume8
Issue number26
DOIs
Publication statusPublished - 27 Jun 2017

Keywords

  • gene expression
  • Gleason score
  • prostate cancer
  • recurrence
  • metastasis
  • NEEDLE-BIOPSY COHORT
  • GENOMIC CLASSIFIER
  • BIOCHEMICAL RECURRENCE
  • RISK STRATIFICATION
  • METASTATIC-DISEASE
  • PROGRESSION
  • VALIDATION
  • POPULATION
  • CARCINOMA
  • DEATH

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