Gene Expression o Endocannabinoid System Components in Skeletal Muscle and Adipose Tissue of South Asians and White Caucasians with Overweight

Kimberly J. Nahon*, Vasudev Kantae, Roy den Haan, Mark J. W. Hanssen, Amy C. Harms, Mario van der Stelt, Thomas Hankemeier, Ingrid M. Jazet, Wouter D. van Marken Lichtenbelt, Patrick C. N. Rensen, Mariette R. Boon

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Objective: The study aimed to investigate whether markers of endocannabinoid signaling differed between overweight men of South Asian and white Caucasian descent.

Methods: We included South Asian (n=10) and white Caucasian (n =10) men with overweight and prediabetes aged 35 to 50 years. Plasma samples were analyzed for endocannabinoids, their congeners, and lipids. In white adipose tissue and skeletal muscle biopsies, mRNA expression of genes involved in the endocannabinoid system was assessed using quantitative RT-PCR. Fasting lipid oxidation and glucose oxidation were determined with indirect calorimetry.

Results: Compared with white Caucasians, South Asians had higher levels of plasma 2-linoleoyl glycerol (P

Conclusions: Overweight South Asian men have higher plasma 2-linoleoyl glycerol and N-linoleoylethanolamine levels and lower gene expression of CB receptors and the endocannabinoid degradation enzyme FAAH2 in skeletal muscle compared with white Caucasians.

Original languageEnglish
Pages (from-to)1332-1337
Number of pages6
JournalObesity
Volume26
Issue number8
DOIs
Publication statusPublished - Aug 2018

Keywords

  • DIETARY-FAT INTAKE
  • OBESITY
  • DYSREGULATION
  • RECEPTORS
  • CELLS
  • OLEOYLETHANOLAMIDE
  • ACTIVATION

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